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MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
ProteomicsB7-H4 post-translational modifications
B7-H4 functions as an immune checkpoint in the tumor microenvironment (TME). However, the post-translational modification (PTM) of B7-H4 and its translational potential in cancer remains incompletely understood. We found that ZDHHC3, a zinc finger DHHC-type palmitoyltransferase, palmitoylates B7-H4 ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-14 | PXD054393 | Pride
Lysosome Palmitoylation Breast cancers Abemaciclib B7-h4 
UnknownThe lncRNA NEAT1 activates Wnt/β-catenin signaling and promotes colorectal cancer progression via interacting with DDX5.
Not available
S-EPMC6125951 | biostudies-literature
TranscriptomicsGenome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes
Stat5+/- mice were bred into the C57BL/6 background. Stat5+/- mice were intercrossed and mouse embryonic fibroblasts (MEFs) were isolated from 12.5-13.5-day WT or Stat5-/- fetuses. The retroviral-expression vector carrying a wild-type Stat5A gene based on an MSCV-IRES-GFP backbone (gift from Richard...
ORGANISM(S): Mus musculus 
2012-03-14 | E-GEOD-33688 | biostudies-arrayexpress
ProteomicsMass spectrometry analysis of proteins interacting with STC1
identify the potential partners of STC1 at the protein level, we performed mass spectrometry on B16-F10 tumor cells stably expressing FLAG-tagged STC1.
ORGANISM(S): Mus musculus (Mouse) 
2020-12-23 | PXD023251 | Pride
Ms Ip Stc1 B16-f10 tumor cells 
ProteomicsPAD4 controls tumor immunity via restraining the MHC-II machinery in macrophages
Tumor-associated macrophages (TAMs) shape tumor immunity and therapeutic efficacy. However, it is poorly understood if and how post-translational modifications (PTMs) intrinsically affect the phenotype and function of TAMs. Here, we found that peptidylarginine deiminase 4 (PAD4) manifested the highe...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD049188 | Pride
T cell Macrophage Pias Checkpoint Mhc Immunotherapy Tumor Pad4 Citrullination Stat1 
MetabolomicsRisk assessment with gut microbiome and metabolite markers in NAFLD development
A growing body of evidence suggests interplay between the gut microbiota and the pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, the role of the gut microbiome in early detection of NAFLD is unclear. Prospective studies are necessary for identifying reliable, microbiome markers fo...
2022-07-11 | MTBLS2615 | MetaboLights
ProteomicsProteomics analysis of glioma cells and astrocytes
Cell membranes harvested from U251 and primary healthy astrocytes were prepared for LC-MS/MS analysis. After analysis, we could obtain a pool of proteins, which were enriched in the U251 cell membrane sample rather than healthy astrocyte membrane sample.
ORGANISM(S): Homo Sapiens 
2022-01-06 | PXD030760 |
ProteomicsTRIM28 is an E3 ligase of IRP2 suppressing ischemia/reperfusion-induced myocardial ferroptosis
Myocardial ischemia/reperfusion (I/R) injury is a common and severe clinical complication in patients with ischemic heart disease (IHD) after reperfusion therapy. Effective therapeutic strategies for myocardial I/R injury remain limited. Ferroptosis is a form of regulated cell death characterized by...
ORGANISM(S): Rattus Norvegicus 
2025-12-28 | PXD072478 |
TranscriptomicsEpigenetic silencing of Th1 chemokines shapes tumor immunity, immunotherapy and patient outcome [shEZH2]
To define the gene profile altered by EZH2 and H3K27me3 in response to IFNg, we performed several microarrays in primary ovarian cancer cells transfected with shEZH2 or treated with GSK126. We found that 155 and 124 genes were altered by shEZH2 and GSK126 treatment, respectively, and 20 genes were i...
ORGANISM(S): Homo sapiens 
2015-08-11 | E-GEOD-71870 | biostudies-arrayexpress
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