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ProteomicsAnti-tumor effects of PIM/PI3K/mTOR triple kinase inhibitor IBL-302 in neuroblastoma
The PI3K pathway is a major driver of cancer progression. However, clinical resistance to PI3K inhibition is common. IBL-302 is a novel highly specific triple PIM, PI3K and mTOR inhibitor. Screening IBL-302 in over 700 cell lines representing 47 tumor types identified neuroblastoma as a strong candi...
ORGANISM(S): Homo sapiens (Human) 
2019-07-11 | PXD014234 | Pride
Neuroblastoma Pi3k Ibl-302 Cisplatin Multikinase inhibition Lc-ms/ms 
ProteomicsRefinement of Protein Extraction Protocols for Human Peripheral Nerve Tissue
Our aim was to establish an effective method for protein extraction from freshly frozen human peripheral nerves and determine the minimum amount required for consistent protein extraction outcomes. Five extraction methods were compared using 8 M Urea and Ripa buffer, using either the Bullet Blender ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-21 | PXD049366 | Pride
Sural nerve Human Extracellular proteins Nerve regeneration Proteomics Lc-ms/ms 
ProteomicsQuantitative Mass Spectrometry Analysis of the Injured Proximal and Distal Human Digital Nerve Ends
Proteomic analysis of injured human peripheral nerves, particularly focusing on events occurring in the proximal and distal nerve ends, remains relatively underexplored. This study aimed to investigate the molecular patterns underlying a digital nerve injury, concentrating on differences in protein ...
ORGANISM(S): Homo sapiens (Human) 
2024-07-19 | PXD051266 | Pride
Digital nerve injury Quantitative mass spectrometry Signal transduction Peripheral nerve injury Nerve injury pathways Extracellular matrix Proteomics 
ProteomicsAngiotensinogen and C3 compete for renin-induced complement activation
Demonstration of renin cleavage of C3. Angiotensinogen and C3 compete for renin-induced complement activation.
ORGANISM(S): Homo sapiens (Human) 
2025-04-18 | PXD053116 | Pride
C3 Renin Angiotensinogen Lc-ms/ms 
ProteomicsADAR3 modulates neuronal differentiation and regulates mRNA stability and translation
This study aims to elucidate potential functions of the editing-deficient ADAR3 enzyme in Mouse. This dataset aims to investigate the binding partners of the ADAR3 enzyme, both with and without RNAse treatment in order to differentiate between RNA dependent and independent interactions. The control ...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-04 | PXD042819 | Pride
Adar3 co-ip N2a cells Mouse Brain Adar 
ProteomicsProteome of neutrophils upon migration towards inflamed synovial fluid
Analysis of neutrophil proteomic alterations induced by migration towards inflamed joints in juvenile idiopathic arthritis (JIA). In this experiment neutrophil proteomes were investigated after migration towards JIA synovial fluid in an in vitro model of a synovial membrane, compared to neutrophils ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD029129 | Pride
Juvenile idiopathic arthritis Migration Synovial fluid Neutrophil 
ProteomicsContraction of brain pericytes in response to Islet Amyloid PolyPeptide is reversed by pramlintide.
The islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However, IAPP aggregates, related to type 2 diabetes mellitus (T2DM), are toxic not only for the pancreas, but also for the brain. In the latter, IAPP is often found in vessels, where i...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035048 | Pride
Amylin Vasculopathy Blood-brain barrier Diabetes Lc-ms/ms 
ProteomicsProject title: Endogenous AIRE-immunoprecipitation from primary human neutrophils
Autoimmune regulator (AIRE) is a transcriptional regulator. We here assess the role for AIRE in primary human neutrophils. We found that the functional role for AIRE in neutrophils is to regulate the extrinsic apoptotic pathway involving the Fas/TNFR death receptors and Cathepsin G and the expressio...
ORGANISM(S): Homo sapiens (Human) 
2024-01-25 | PXD047989 | Pride
Neutrophil Aire Human 
ProteomicsNovel Targeted Proteomic Profiling of Potential Biomarkers in Postural Orthostatic Tachycardia Syndrome (POTS)
Postural orthostatic tachycardia syndrome (POTS) is a cardiovascular autonomic disorder leading to debilitating symptoms and the therapeutic alternatives are limited. Proteomics is a large-scale study of proteins that enables a systematic unbiased view on disease and health, allowing stratification ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-24 | PXD031458 | Pride
Lc-msms Postural orthostatic tachycardia syndrome Proteomics Pots Biomarkers 
ProteomicsTartrate resistant acid phosphatase 5 (TRAP5) mediates immune cell recruitment in a murine model of pulmonary bacterial infection
During airway infection, upregulation of proinflammatory cytokines and subsequent immune cell recruitment is essential to mitigate bacterial infection. Conversely, during prolonged and non-resolving airway inflammation, neutrophils contribute to tissue damage and remodeling. This occurs during disea...
ORGANISM(S): Homo sapiens (Human) 
2022-12-30 | PXD038135 | Pride
Nf‐b Copd Acp5 Spp1 Trap5 Pseudomonas aeruginosa Cystic fibrosis 
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