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ProteomicsC. rodentium remodels metabolism in IEC
The mechanisms by which the mouse pathogen Citrobacter rodentium triggers effacement of the brush border microvilli, colitis, hyperplasia and dysbiosis remain poorly understood. We investigated the impact of C. rodentium infection on the proteomic and metabolic landscapes of intestinal epithelial ce...
ORGANISM(S): Citrobacter rodentium Mus musculus (Mouse) 
2018-01-10 | PXD005004 | Pride
Colon Lc-msms Citrobacter rodentium Mouse Tmt Phosphorylation 
ProteomicsGenomic determinants of protein abundance variation in colorectal cancer cell lines
Assessing the impact of genomic alterations on protein networks is fundamental in identifying the mechanisms that shape cancer heterogeneity. We have used isobaric labelling to characterize the proteomic landscapes of 50 colorectal cancer cell lines and to decipher the functional consequences of som...
ORGANISM(S): Homo sapiens (Human) 
2017-08-09 | PXD005235 | Pride
Networks Tmt Proteomics Protein complexes Crispr/cas9 Phosphorylation Cell lines Drug response Mutations Colorectal cancer 
ProteomicsMolecular signatures after challenge with Salmonella Typhi implicate host tryptophan metabolism in the pathogenesis of typhoid fever, part 1
Induced pluripotent stem (iPS) cell derived human macrophages were stimulated with IFN-y or exposed to viable S. Typhimurium SL1344 using either a gentamicin invasion assay or after over-night priming with IFN-y. Protein abundance changes between samples was determined relative to unstimulated contr...
ORGANISM(S): Homo sapiens (Human) 
2016-05-31 | PXD001953 | Pride
Human Macrophages Salmonella typhi Tmt Ips 
ProteomicsMolecular signatures after challenge with Salmonella Typhi implicate host tryptophan metabolism in the pathogenesis of typhoid fever, part 2
Label free quantitation using DIA HDMSe of Salmonella infected and uninfected mouse caecum tissue
ORGANISM(S): Mus musculus (Mouse) 
2020-01-21 | PXD001954 | Pride
Salmonella typhi Hdmse Label free Mouse Caecum Tissue 
ProteomicsProteogenomics reanalysis of human testis data
Reanalysis of the human testis tissue dataset acquired for the Chromosome-centric Human Proteome Project (C-HPP; PRIDE project PXD002179), with a focus on identifying novel peptides for genome annotation.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-13 | MSV000083973 | MassIVE
ProteomicsEROS/CYBC1 CONTROLS THE PHAGOCYTE RESPIRATORY BURST VIA DIRECT INTERACTION WITH GP91PHOX AND HAS A NOVEL ROLE IN NLRP3 INFLAMMASOME ACTIVATION
EROS (Essential for Reactive Oxygen Species) protein (CYBC1) is indispensable for expression of the gp91phox-p22phox heterodimer of the phagocyte NADPH oxidase. EROS deficiency in humans is a novel cause of chronic granulomatous disease (CGD) but its mechanism of action remains unclear. Our work des...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD024659 | Pride
Chronic granulomatous disease Eros P2x7 Cybc1 Gp91phox Nadph oxidase 
ProteomicsDIPG harbour alterations targetable by MEK inhibitors, with acquired resistance mechanisms overcome by combinatorial inhibition
The survival of children with DIPG remains dismal, with new treatments desperately needed. In the era of precision medicine, targeted therapies represent an exciting treatment opportunity, yet resistance can rapidly emerge, playing an important role in treatment failure. In a prospective biopsy-stra...
ORGANISM(S): Homo sapiens (Human) 
2021-07-20 | PXD019701 | Pride
Lc-msms Tmt Clinical Dipg 
ProteomicsDissecting the malaria interactome
To identify malaria protein interactions systematically we combined blue native polyacrylamide electrophoresis fractionation with quantitative mass spectrometry and machine learning. Our integrative approach identified over twenty thousand protein interactions in Plasmodium schizonts, organized into...
ORGANISM(S): Plasmodium berghei 
2019-08-06 | PXD010117 | Pride
Malaria Berghei 
ProteomicsDissecting the malaria interactome
To identify malaria protein interactions systematically we combined blue native polyacrylamide electrophoresis fractionation with quantitative mass spectrometry and machine learning. Our integrative approach identified over twenty thousand protein interactions in Plasmodium schizonts, organized into...
ORGANISM(S): Homo sapiens (Human) 
2019-08-06 | PXD009039 | Pride
Fractionation Schizont Malaria Blue native page P. berghei Protein-protein interactions P. knowlesi Interactome Plasmodium P. falciparum Multiprotein complexes 
ProteomicsA knockout screen of ApiAP2 genes reveals networks of interacting transcriptional regulators controlling the Plasmodium life cycle.
The family of apicomplexa-specific proteins with DNA binding AP2 domains (ApiAP2s) includes sequence-specific transcription factors that are key regulators of development in malaria parasites. However, functions for the majority of ApiAP2 genes remain unknown. Here, a systematic knockout screen in P...
ORGANISM(S): Plasmodium berghei 
2017-02-08 | PXD005180 | Pride
Plasmodium Tmt Malaria 
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