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ProteomicsProteoglycan sequencing - Deep sequencing of complex proteoglycans: a novel strategy for high coverage and site-specific identification of glycosaminoglycan-linked peptides
Proteoglycans are distributed in all animal tissues and play critical, multifaceted, physiological roles. Expressed in a spatially- and temporally-regulated manner, these molecules regulate interactions among growth factors and cell surface receptors and play key roles in basement membranes and oth...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2018-05-22 | PXD008855 | Pride
Neurocan Decorin Lc-ms Aggrecan Brevican 
ProteomicsGlycopeptide Relative Retention Time Prediction
A re-analysis of published data-dependent acquisition glycoproteomics datasets to demonstrate relative retention time prediction on glycopeptide identification and disambiguation of adduct states.
ORGANISM(S): Homo sapiens (Human) 
2020-04-01 | PXD018208 | Pride
Glycoproteomics 
ProteomicsInfluenza A hemagglutinin glycoproteomics similarity
Influenza A virus (IAV) mutates rapidly, preventing a single seasonal vaccine from targeting more than one strain, and year-to-year vaccine effectiveness is low. One challenge in designing effective vaccines is that genetic mutations frequently cause amino acid variations in IAV envelope protein hem...
ORGANISM(S): Viruses Homo sapiens (Human) Gallus gallus (Chicken) 
2020-07-03 | PXD018920 | Pride
Glycosylation Influenza a Lc-ms Similarity Glycopeptides 
ProteomicsGAGfinder: glycosaminoglycan MS/MS fragment peak finding and elemental composition assignment
This study shows the efficacy of a new tandem mass spectrometry peak finding software, GAGfinder. GAGfinder works by iterating through all potential fragments of a given precursor composition and comparing a theoretical isotopic distribution to the peak heights found in a tandem mass spectrum. We us...
ORGANISM(S): Homo sapiens (Human) 
2018-04-09 | PXD009101 | Pride
Glycosaminoglycans Chondroitin sulfate Heparan sulfate Bioinformatics Keratan sulfate 
ProteomicsN- and O-Glycoproteomic Analysis of Complex Proteoglycans
Proteoglycans are a small but diverse family of proteins that play a wide variety of roles at the cell surface and extracellular matrix. In addition to their glycosaminoglycan (GAG) chains, they are also N- and O-glycosylated. All of these types of glycosylation are crucial to their function, but pr...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2025-05-06 | PXD041935 | Pride
Proteoglycans Glycoproteomics Tandem mass spectrometry 
ProteomicsImproving statistical certainty of glycosylation similarity between influenza A virus variants using data-independent acquisition mass spectrometry
The amino acid sequences of immunodominant domains of hemagglutinin (HA) on the surface of influenza A virus (IAV) evolve rapidly, producing viral variants. HA mediates receptor recognition, binding and cell entry, and serves as the target for IAV vaccines. Glycosylation, a post-translational modifi...
ORGANISM(S): Homo sapiens (Human) Canis familiaris (Dog) (Canis lupus familiaris) Gallus gallus (Chicken) 
2022-09-24 | PXD029700 | Pride
Influenza Dia Glycoproteomics Mass spectrometry Glycosylation similarity Hemagglutinin 
ProteomicsIn-depth matrisome and glycoproteomic analysis of glioblastoma human brain tissue
Glioblastoma (GBM) is the most common and malignant primary brain tumor. The extracellular matrix (ECM), also known as the matrisome, helps determine glioma invasion, adhesion, and growth. Little attention, however, has been paid to glycosylation of the ECM components that constitute the majority of...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD028931 | Pride
Glycosylation Proteomics Chondroitin sulfate Glycoproteins Glycosaminoglycans Mass-spectrometry Glioblastoma Matrisome Heparan sulfate Proteoglycans Glycomics Extracellular matrix 
ProteomicsOligosaccharide Substrate Preferences of Human Extracellular Sulfatase Sulf2
In this study, we characterized the substrate preferences of human HSulf2 using HS oligosaccharides with various lengths and sulfation degrees from several naturally occurring HS sources by applying liquid chromatography mass spectrometry based glycomics methods.
ORGANISM(S): Bos taurus (Bovine) 
2014-07-22 | PXD001157 | Pride
Sulf2 Substrate preference Glycomics 
ProteomicsData-independent acquisition mass spectrometry for site-specific glycoproteomics characterization of SARS-CoV-2 spike protein
The spike protein of SARS-CoV-2, the virus responsible for the global pandemic of COVID-19, is an abundant, heavily glycosylated surface protein that plays a key role in receptor binding and host cell fusion, and is the focus of all current vaccine development efforts. Variants of concern are now ci...
ORGANISM(S): Homo sapiens (Human) 
2022-02-12 | PXD027425 | Pride
Glycosylation Dia Glycoproteomics Sars-cov-2 Mass spectrometry Spike protein 
ProteomicsData-independent acquisition mass spectrometry for site-specific glycoproteomics characterization of SARS-CoV-2 spike protein
The spike protein of SARS-CoV-2, the virus responsible for the global pandemic of COVID-19, is an abundant, heavily glycosylated surface protein that plays a key role in receptor binding and host cell fusion, and is the focus of all current vaccine development efforts. Variants of concern are now ci...
ORGANISM(S): Homo sapiens (Human) 
2022-09-12 | PXD027279 | Pride
Glycosylation Dia Glycoproteomics Sars-cov-2 Mass spectrometry Spike protein 
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