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MetabolomicsSerum metabolomic profiles for distinguishing lung cancer from pulmonary tuberculosis: identification of rapid and noninvasive biomarker

BACKGROUND: Pulmonary tuberculosis (TB) and lung cancer (LC) have similar clinical symptoms and atypical imaging findings which are easily misdiagnosed. There is an urgent need for a noninvasive, rapid and accurate biomarker for distinguishing LC from TB.

METHODS:

2024-01-16 | MTBLS6990 | MetaboLights
ProteomicsS-nitrosocysteine proteomics of Schistosoma japonicum collected from infected mice and rats
Rats and mice were infected with Schistosoma japonicum, and the worms were collected from infected rats and mice. Worms in rats were exposed to high level of NO, while the worms in mice were not. Then a S-nitrosocysteine proteomics of Schistosoma japonicum collected from infected rats and mice was p...
ORGANISM(S): Schistosoma Japonicum 
2024-04-19 | PXD041667 |
MetabolomicsAge-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates.

The incidence of intestinal diseases increases with age, but the regulators of gut aging and the molecules linking gut aging and diseases remain largely unknown. By profiling the transcriptome, proteome, phosphoproteome and metabolome of 104 Macaca fascicularis large intestinal tissues, ...

2023-12-14 | MTBLS7612 | MetaboLights
MetabolomicsDistinct metabolic profiling is correlated with bisexual flowers formation resulting from exogenous ethephon induction in melon (Cucumis melo L.)

Melon (Cucumis melo L.) is an agronomically important vegetable. Most cultivars of melon are andromonoecious and bisexual flowers only emerged from the leaf axil of lateral branches. However, the regulatory mechanism contributing to the occurrence of bisexual flowers were still obscure. ...

2022-03-10 | MTBLS2993 | MetaboLights
ProteomicsIdentification of Khib substrates of histone regulated by NAT10
Having established NAT10’s regulatory role in lysine 2-hydroxyisobutyrylation, we aimed to identify the histone Khib sites targetedby NAT10. To this end, we extracted and digested core histones from cells with or without NAT10 depletion, followed by chemical derivatization of amine groups. The resul...
ORGANISM(S): Homo sapiens (Human) 
2026-01-27 | PXD066039 | Pride
Human liver cancer histone hplc-ms/ms 
ProteomicsDifferential Proteomics of pprI-Knockout Deinococcus radiodurans: A Label-Free Quantitative Analysis
Deinococcus radiodurans, renowned for its exceptional resistance to radiation, provides a robust model for elucidating cellular stress responses and DNA repair mechanisms. The global regulator PprI plays a pivotal role in maintaining this resilience by coordinating DNA damage repair, antioxidant def...
ORGANISM(S): Deinococcus radiodurans 
2025-06-30 | PXD062500 | Pride
Radiation response metalloprotease  label-free quantitative proteomics  dna damage repair  antioxidant defense  metabolic regulation 
Proteomicslabel free quantitative proteomics for determining the biological characterastic of eukaryocyte with or without BHB.
BHB is the major part of ketone body in plasm that is usually at low concentration. Dramatical increase of BHB is due to prologation fasting or diabetes. In addation to enegetic carrier for metabolic reprogramming, BHB is also involved in epigenetic regulation. Here, we illustrats the BHB-induced pr...
ORGANISM(S): Homo sapiens (Human) 
2025-07-04 | PXD051685 | Pride
Human Bhb Label-free Lc-ms/ms 
ProteomicsLabel-free DDA proteome for identifying the interacting proteins of HBO1
HBO1 is an important transcriptional activator for organism to respond to natural stress. Here, we performed IP-MS for determining the interacting proteins of HBO1 under stimulation of BHB.
ORGANISM(S): Homo sapiens (Human) 
2025-07-04 | PXD051692 | Pride
Human Label-free Ip-ms Hbo1 
ProteomicsSILAC based quantitative 3-hydroxybutyromics of HBO1-WT and HBO1-KO HeLa cells
Ketogenesis derived BHB facilitates 3-hydroxybutyrylation on lysine linking metabolism with epigenetic regulation. Herein, we found HBO1 served as 3-hydroxybutyryltransferase preferentially catalyzing lysine 9 of histone H3 (H3K9bhb). Moreover, total 1171 Kbhb sites on 582 proteins were identified. ...
ORGANISM(S): Homo sapiens (Human) 
2025-07-04 | PXD051668 | Pride
Human Cervical cancer Kbhb Hbo1 Lc-ms/ms 
ProteomicsSILAC experiment quantifying the proteomics of WT and HBO1-KO HeLa
Lysine lactylation (Kla) links metabolism and gene regulation and plays a key role in multiple biological processes. We report that HBO1 functions as a lysine lactyltransferase to regulate transcription. Quantitative proteomic analysis further revealsed 95 endogenous Kla sites targeted by HBO1, with...
ORGANISM(S): Homo sapiens (Human) 
2024-04-13 | PXD051415 | Pride
Hela Lc-msms Hbo1 Kla 
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