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ProteomicsAge-dependent hippocampal proteomics in the APP/PS1 Alzheimer mouse model: a comparative analysis with classical SWATH/DIA and directDIA approaches
Alzheimer’s disease (AD) is the most common neurodegenerative disorder in the human population, for which there is currently no cure. The cause of AD is unknown, however, the toxic effects of amyloid-β (Aβ) are believed to play a role in its onset. To investigate this, we examined changes in global ...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-24 | PXD025777 | Pride
Proteomics Alzheimer Microglia App/ps1 mouse model Directdia Ms-dap 
ProteomicsAPP/PS1 Mouse Brain Effects of ADAM17
Affects of ADAM17 AAV9 mediated injection on cognitive and vascular function in the APP/PS1 mouse model of Alzheimer's disease.
ORGANISM(S): Mus musculus (Mouse) 
2023-03-02 | PXD040026 | Pride
Brain App/ps1 Mouse Adam17 
TranscriptomicsEffect of ibuprofen on hippocampal gene expression in APP-PS1 mice
NSAIDs (non-steroidal anti-inflammatory drugs) inhibit cyclooxygenase (COX) enzymes and prevent Alzheimer'™s disease (AD) at preclinical stages in cognitively normal aging populations. We modeled NSAID prevention of memory impairment in AD model mice to identify novel targets of NSAID action. We fou...
ORGANISM(S): Mus musculus 
2016-06-14 | E-GEOD-67306 | biostudies-arrayexpress
TranscriptomicsRNA-seq of hippocampal samples from IL-18KO/APP/PS1 , WT, IL-18KO, and APP/PS1 mice.
The goal of the experiment was to understand the role of IL-18 in Alzheimers disease. Gene expression was examined in the hippocampus of wild type mice and the APP/PS1 mice (which are a mouse model for Alzheimers disease) that either encoded IL-18 or had the IL-18 gene knocked out.
ORGANISM(S): Mus musculus domesticus 
2017-12-31 | E-MTAB-5668 | biostudies-arrayexpress
TranscriptomicsAPP/PS1 mice characterization and time progression.
RNA samples from the cerebral cortex of APP/PS1 and WT mouse littermates aged 3, 6 and 12 months were analyzed using the Affymetrix Genechip Mouse Gene 1.1 ST Array. The APP-PS1 transgenic mouse express the human mutated forms APPswe and PS1dE9. This is a good model of familial Alzheimer Disease bec...
ORGANISM(S): Mus musculus 
2014-04-30 | E-MTAB-2121 | biostudies-arrayexpress
ProteomicsProteome profiling in APP/PS1 mice brain and modulation by tocotrienol-rich fraction
This study examined the proteome profile in the hippocampus, medial prefrontal cortex, and striatum of APPswe/PS1dE9 transgenic mice (APP/PS1) model of Alzheimer’s disease compared to wild-type mice. The effect of tocotrienol-rich fraction (TRF), a mixture of vitamin E analogs derived from palm oil ...
ORGANISM(S): Mus musculus (Mouse) 
2019-12-06 | PXD011068 | Pride
App/ps1 mice Alzheimer’s disease Brain Vitamin e Tocotrienol-rich fraction 
ProteomicsAn integrated omics approach reveals synaptic plasticity changes in an APP/PS1 Alzheimer´s mouse model
Synaptic dysfunction occurs early in Alzheimer´s disease. However, efforts to protect against these detriments have not been possible due to the inadequate understanding of synaptic signalling pathways involved in the neuropathological disease process. The aim of this study was to elucidate the mole...
ORGANISM(S): Mus musculus (Mouse) 
2016-05-11 | PXD003312 | Pride
Cortex Synapse Neuroinflammation Tau protein Proteomics Hippocampus Mirna Amyloid Olfactory bulb Dendritic spine Brainstem 
GenomicsExpression data from WT mouse amd 9-month-old APP/PS1 mouse
Expression data from WT mouse amd 9-month-old APP/PS1 mouse
PRJNA431171 | ENA
ProteomicsQuantitative proteomic characterization of senile plaques from APP/PS1 mice brain
The deposition of amyloid senile plaques (SPs) plays a central role in Alzheimer’s disease (AD), but the mechanisms by which SPs induce neural toxicity are disputed. Genetically engineered mouse models emphasizing SPs have had limited success in reproducing the neuropathology of AD, and have also fa...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-20 | PXD005876 | Pride
Brain Mouse Alzheimer's disease Amyloid plaque Senile plaque 
ProteomicsDysregulation of the de novo proteome accompanies pathology progression in the APP/PS1 mouse model
We hypothesize that alterations in the de novo proteome drive early metabolic alterations in the hippocampus that persist throughout AD progression. Using a combinatorial amino acid tagging approach to selectively label newly synthesized proteins, we found that the de novo proteome is disturbed in A...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-08-17 | MSV000085962 | MassIVE
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