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ProteomicsInternal Ribosome Entry Site RNAs act in trans through an antisense sequence
SINEUPs are antisense long non-coding RNAs (lncRNAs) that increase translation of overlapping mRNAs through the activity of two domains: an embedded SINEB2 sequence UP-regulates translation (Effector Domain) while the antisense region provides target specificity (Binding Domain). In this study, we ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD028571 | Pride
Proteomics Circ5533 Pxk Binding domain Sineups 
ProteomicsA SWATH LABEL-FREE PROTEOMICS INSIGHT INTO THE FAAH-/- MOUSE LIVER
Fatty acid amide hydrolase (FAAH) is an important enzyme for lipid metabolism and an interesting pharmacological target, given its role in anandamide breakdown. The FAAH-/- genotype is the most widely used mouse model to achieve complete abolition of this enzyme. In this paper we explore, by means ...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-20 | PXD010087 | Pride
Faah Swath Liver proteomics 
ProteomicsInhibition of human glioblastoma invasion and growth upon co-administration of a synergic miRNA pool actuated in vivo by nanocarriers
Although small interfering RNAs are being routinely used in the clinic, the therapeutic potential of oncogene co-regulation via multiple microRNAs (miRNAs) is still vastly underexplored. Here, the functional synergism of a pool of 11 miRNAs, which are involved in neural stem cell differentiation, wa...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD020335 | Pride
Nanoformulation Mirna Glioblastoma 
ProteomicsImpact of Cerium Oxide Nanoparticles on Rat Myoblast Proteome
Oxidative stress is a widespread causative agent of disease. Together with its general relevance for biomedicine, such dynamic is recognizably detrimental to space exploration. Among other solutions, cerium oxide nanoparticles (or nanoceria, NC) display a long-lasting, self-renewable antioxidant act...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-06-09 | PXD047391 | Pride
Proteomics Nanoceria Nanoparticles 
ProteomicsNew method to investigate protein orientation in corona of nanomaterials
The composition and structure of protein corona represents a crucial factor that controls the biological properties and fate of nanomaterials. While the composition of the corona can relatively easily be investigated by conventional bottom-up proteomics, assessing the spatial orientation of a protei...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019524 | Pride
Isobaric labeling Orientation Protein corona 
ProteomicsTFEB regulates protein synthesis to sustain autophagy during starvation
In response to starvation, cells undergo a metabolic shift to ensure their survival by shutting down protein synthesis and activating catabolic processes, including autophagy, to degrade proteins and recycle nutrients. These processes, however, do require protein synthesis. We asked how this fundame...
ORGANISM(S): Homo sapiens (Human) 
2020-09-30 | PXD016149 | Pride
Human hek293 
ProteomicsProteomics analysis of FUS mutant human motoneurons reveals altered regulation of cytoskeleton and other ALS-linked proteins via 3’UTR binding
Increasing evidence suggests that in Amyotrophic Lateral Sclerosis (ALS) mutated RNA binding proteins acquire aberrant functions, leading to altered RNA metabolism with significant impact on encoded protein levels. Here, by taking advantage of a human induced Pluripotent Stem Cell (hiPSC)-based mode...
ORGANISM(S): Homo sapiens (Human) 
2020-10-27 | PXD019596 | Pride
Motoneurons Fus protein Vcp  asap1  3’utr  
ProteomicsInteractions of graphene-based materials with the blood-brain barrier
In this work, we performed an in vitro investigation of GRM interactions with the BBB. To this aim,we employed GRMs with different surface chemistry and stability, both murine and human models of increasing complexity, and a portfolio of complementary label-free analytical techniques. The use of lab...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD038297 | Pride
Proteomics Graphene Blood-brain barrier 
ProteomicsMiR-135a-5p is critical for exercise-induced proliferation of adult neurogenesis
Physical exercise stimulates adult hippocampal neurogenesis in mammals, and is considered a relevant strategy for preventing age-related cognitive decline in aging humans. However, its mechanism is controversial. Here, by investigating microRNAs (miRNAs) and their downstream pathways, we uncover tha...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD009845 | Pride
Swath Mirna Adult neurogenesis 
ProteomicsPolydopamine nanoparticles (PDNPs) to remotely modulate the activity of differentiated SH-SY5Y cells and differentiated C2C12 cells
The precise control of cell activity is crucial for understanding and potentially treating many disorders. Focusing on neurons and myotubes, recent advancements in nanotechnology have introduced photoresponsive nanoparticles as a novel tool for modulating cell function with high spatial and temporal...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-04-23 | PXD061533 | Pride
Neurons Polydopamine Nir Nanoparticles 
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