Sort   by:  
 Page size 
ProteomicsSILAC-based phosphoproteomics reveals new PP2A-Cdc55-regulated processes in budding yeast.
Protein phosphatase 2A (PP2A) is a family of conserved serine/threonine phosphatases involved in several essential aspects of cell growth and proliferation. PP2ACdc55 phosphatase has been extensively related to cell cycle events in budding yeast, however few PP2ACdc55 substrates have been identified...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-04-16 | PXD007613 | Pride
Pkc1 Mob1. Mitotic exit network (men) Pp2acdc55 phosphatase Cla4 
ProteomicsDiscovery, characterization and quantification of bioactive peptides contained in Palbio porcine intestinal mucosa hy-drolysate products.
Porcine intestinal mucosa hydrolysates (PIMH) are a by-product of heparin production obtained through a specific enzymatic hydrolysis process which can theoretically generate bioactive pep-tides (BAPs). This study aimed to identify, characterize and quantify BAPs in two Palbio products manufactured ...
ORGANISM(S): Sus scrofa (Pig) 
2025-08-04 | PXD063531 | Pride
Bioactive peptides  antimicrobial peptides  sustainable processing  porcine intestinal mucosa hydrolysate  porcine digestible peptides  bio-compound valorization  animal by-products 
ProteomicsEvaluation of tumor interstitial fluid-extraction methods for proteome analysis: comparison of biopsy elution versus centrifugation
The analysis of Tumor Interstitial Fluid (TIF) composition is a valuable procedure to identify anti-metastatic targets, and different laboratories have set up techniques for TIF isolation and proteomic analyses. However, those methods had never been compared in samples from the same tumor and patien...
ORGANISM(S): Homo sapiens (Human) 
2020-05-06 | PXD016261 | Pride
Cutaneous squamous cell carcinoma Skin cancer Tumor interstitial fluid Spin Proteome Centrifugation Elution 
ProteomicsBiomarkers found in the tumor interstitial fluid may help explain the differential behavior among keratinocyte carcinomas
Keratinocyte carcinomas (KC) are the most common malignancy worldwide. This category of tumours groups both basal (BCC) and squamous (SCC) cell carcinomas. While the former rarely metastasizes (0.03-0.55%), the latter is more associated to a substantial risk of local recurrence, metastasis and death...
ORGANISM(S): Homo sapiens (Human) 
2023-04-14 | PXD036900 | Pride
Orbitrap dusion lumos Basal cell carcinoma Squamous cell carcinoma Tumor interstitial fluid Label free 
ProteomicsInhibition of CBP synergizes with the RNA-dependent mechanisms of azacitidine by limiting protein translation
The nucleotide analogue azacitidine (AZA) interferes with RNA and DNA metabolism and is currently the best treatment option for a subset of patients with high-risk myelodysplastic syndromes. However, only half of treated patients respond and almost all patients that initially respond eventually rela...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD021738 | Pride
Hypomethylating agents  azacitidine  epigenetic regulation  lysine acetyl tranferase inhibitors  creb binding protein / cbp / p300  shrna screen  protein synthesis Clonal hematopoietic disorders Myelodysplastic syndromes  secondary acute myeloid leukemia 
ProteomicsEpigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer
RNA modifications are important regulators of transcript activity and an increasingly emerging body of data suggest that the epitranscriptome and its associated enzymes are altered in human tumors. In this study, the initial screening for genetic and epigenetic defects of 5-methylcytosine RNA methyl...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD038418 | Pride
Peaks Snu cells Nsun7 Tmt16plex Methyltransferase 
ProteomicsEpigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer
RNA modifications are important regulators of transcript activity and an increasingly emerging body of data suggest that the epitranscriptome and its associated enzymes are altered in human tumors. In this study, the initial screening for genetic and epigenetic defects of 5-methylcytosine RNA methyl...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD038422 | Pride
Maxquant Nsun7 Interactome Label free Methyltransferase 
ProteomicsSIRT1 regulates DNA damage signaling through PP4 phosphatase complex
The Sirtuin family of NAD+-dependent enzymes play an important role in the maintenance of genome stability upon stress. Several mammalian Sirtuins have been linked directly or indirectly to the regulation of DNA damage during replication through Homologous recombination (HR). The role of one of them...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-06-15 | PXD036905 | Pride
Label free proteomics Pp4 phosphatase complex H2ax Sirt1 Dna damage response 
ProteomicsExploring Diverse Clinical Presentations in COVID-19 through Circulating Extracellular Vesicle Proteomics Analysis
Extracellular vesicles (EVs) released by virus-infected cells are susceptible to incorporate viral peptides. Here, we hypothesized that the molecular characterization of EVs obtained from COVID-19 patients will reveal novel immunogenic viral peptides. Blood from COVID-19 patients with severe (G1), m...
ORGANISM(S): Homo sapiens (Human) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2024-09-25 | PXD041931 | Pride
Proteomics profiling Covid-19 patients Clinical data Ganglioside-capture(siglec-1) Antibody response Extracellular vesicles Size-exclusion chromatography(sec) Tandem mass tag(tmt) Immunocapture(cd9) 
ProteomicsActivity of the novel BTK inhibitor TG-1701 is associated with the disruption of the Ikaros signaling pathway in responder B-NHL patients and with sensitization to anti-CD20 therapy in B-NHL xenografts
Covalent Bruton's tyrosine kinase inhibitors (BTKis) have transformed the treatment of B-cell non-Hodgkin lymphoma (B-NHL), including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), but their activity has been limited by off-target toxicity and acquired drug resistance. TG-1701 is...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD023231 | Pride
Xenografts Tmt B-nhl Btk Maxquant Tg-1701 Phosphoproteomics Ikaros 
Sort   by:  
 Page size