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ProteomicsSystems pharmacology dissection of cholesterol regulation reveals determinants of large pharmacodynamic variability between cell lines
In individuals, heterogeneous drug response phenotypes result from a complex interplay of dose, drug specificity, genetic background, and environmental factors, thus challenging our understanding of the underlying processes and optimal use of drugs in the clinic. Here, we use mass spectrometry-based...
ORGANISM(S): Homo sapiens (Human) 
2017-12-07 | PXD005955 | Pride
Cholesterol regulation T0901317 Cholesterol homeostasis Hela kyoto Gw3965 Srebp Lxr Hek293 Atorvastatin Srebp1 Srebp2 Npc1 Ldlr Huh7 Hmgcs1 Hepg2 
UnknownSystems Pharmacology Dissection of Cholesterol Regulation Reveals Determinants of Large Pharmacodynamic Variability between Cell Lines.
Not available
S-EPMC5747350 | biostudies-literature
ProteomicsZebrafish SWATH-MS spectral library to quantify 10,000 proteins
Sequential window acquisition of all theoretical mass spectra (SWATH-MS) requires a spectral library to extract quantitative measurements from the mass spectrometry data acquired in data-independent acquisition mode (DIA). Large combined spectral libraries containing SWATH assays have been generated...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2018-12-18 | PXD010876 | Pride
Eye Intestine Heart Brain Liver Zebrafish Ovaries Spleen Testes Muscle 
ProteomicsProteomics of preclinical model of skin dermatitis
To assess the preclinical Aldara model, the proteomic response of mouse skin to topical applied Aldara cream was assessed using untargeted LC-MS. Skin from sham treated or treated with the Aldara cream were compared for 4 independent experiments after 8 days of treatment.
ORGANISM(S): Mus musculus (Mouse) 
2025-04-22 | PXD056245 | Pride
Mouse Orbitrap qe-hf-x Skin 
ProteomicsQuantification of brain, muscle, and liver using large SWATH-spectral library
Sequential window acquisition of all theoretical mass spectra (SWATH-MS) requires a spectral library to extract quantitative measurements from the mass spectrometry data acquired in data-independent acquisition mode (DIA). Large combined spectral libraries containing SWATH assays have been generated...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2018-12-18 | PXD010869 | Pride
Brain Liver Zebrafish Muscle 
ProteomicsDIA analysis of colorectal cancer organoids (cancer vs metastasis)
The goal of this project was to characterize the proteome of colorectal cancer organoids from a metastatic and original tumor.
ORGANISM(S): Homo sapiens (Human) 
2023-12-10 | PXD018922 | Pride
Organoids Colorectal cancer 
ProteomicsDIA analysis of colorectal cancer organoids
The goal of this project was to characterize the proteome and phosphoproteome of colorectal cancer organoids.
ORGANISM(S): Homo sapiens (Human) 
2023-12-10 | PXD018913 | Pride
Organoids Prostate Spop 
ProteomicsBuilding a spectral library to analyze colorectal cancer organoids
The goal of this project was to build SWATH Spectral libraries to analyze colorectal cancer organoids.
ORGANISM(S): Homo sapiens (Human) 
2023-12-10 | PXD018835 | Pride
Organoids Colorectal cancer 
ProteomicsBuilding spectral libraries to analyze phosphopeptides in colorectal cancer organoids
The goal of this project was to build SWATH Spectral libraries to analyze phosphopeptides from colorectal cancer organoids.
ORGANISM(S): Homo sapiens (Human) 
2023-12-10 | PXD018862 | Pride
Organoids Colorectal cancer 
ProteomicsPD-1 interacting proteins in SILAC labelled Jurkat cells stimulated with Raji cells - Part4
Identifying PD-1 interacting proteins in Jurkat cells expressing PD-1 after stimulation with Raji cells and the superantigen SEE.
ORGANISM(S): Homo sapiens (Human) 
2019-05-06 | PXD013531 | Pride
Pd-1 Thermo fusion lumos T cells 
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