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ProteomicsCTMM Circulating Cells: Granulocytes in chronic total coronary occlusion
90 min LC-MS/MS run of granulocyte digest (control)
ORGANISM(S): Homo sapiens (Human) 
2013-02-19 | PRD000684 | Pride
ProteomicsArginine to Cysteine substitutants in lung cancer enhance survival to chemotherapy
Tryptophan and arginine are the two most prominent restrictive amino acids linked to anti-tumor activity. For tryptophan, the induction of indoleamine 2,3-dioxygenase 1 (IDO1) by interferon-gamma (IFNg) secreted by T cells, catabolizes tryptophan to kynurenine to suppress T cell activity. For argini...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043612 | Pride
Arginine Substituants Keap1 Lung cancer Tryptophan 
ProteomicsMULTIMODAL STIMULATION SCREENS REVEAL UNIQUE AND SHARED GENES LIMITING T-CELL FITNESS
T-cell dysfunction genes limit antitumor activity and may serve as therapeutic targets. It has not been systematically studied whether there are regulators that either uniquely or broadly contribute to T-cell fitness. We performed genome-scale CRISPR/Cas9 knockout screens in primary CD8 T-cells to u...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-16 | PXD043545 | Pride
T-cells Dap5 Exhaustion Ctbp1 Activation-induced cell death Crispr/cas9 screen Icam1 Effector function Cancer immunotherapy Dysfunction 
ProteomicsChemotherapy-induced codon-specific immunopeptidome diversification
Deregulated mRNA translation in cancer is a source of aberrant protein production when tryptophan shortage is induced by anti-tumor immunity (refs). Tryptophan is decoded by only one codon, and currently the consequences of aberrant protein production in conditions of a shortage of amino acids decod...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044085 | Pride
Aberrant protein Mrna translation Tryptophan Leucine Ribosomal stalling Immunopeptidomics Neoepitopes 
ProteomicsArginine deprivation of ASS1-deficient cancers drives mistranslation and shared neoepitope production
Arginine biosynthesis is frequently suppressed in human cancer due to loss of argininosuccinate synthetase 1 (ASS1) expression, rendering cancer cells reliant on extracellular arginine. This observation propelled the development of systemic arginine depletion strategies, which are clinically safe bu...
ORGANISM(S): Homo sapiens (Human) 
2026-04-28 | PXD068912 | Pride
ProteomicsUBIQUITIN LIGASE STUB1 DESTABILIZES IFNγ-RECEPTOR COMPLEX TO SUPPRESS TUMOR IFNγ SIGNALING
The cytokine IFNγ differentially impacts on tumors upon immune checkpoint blockade (ICB). Despite our understanding of downstream signaling events, less is known about 36 regulation of its receptor (IFNγ-R1). With an unbiased genome-wide CRISPR/Cas9 screen for critical regulators of IFNγ-R1 cell sur...
ORGANISM(S): Homo sapiens (Human) 
2022-03-07 | PXD030580 | Pride
Immune checkpoint blockade Ubiquitination Ifnγ Stub1 Melanoma 
ProteomicsTMED10 INHIBITION SUPPRESSES CELL-SURFACE PD-1 EXPRESSION AND REVERSES T CELL DYSFUNCTION
PD-1 immune checkpoint blockade (ICB) is revolutionizing cancer therapy, but little is known about the mechanisms governing its expression. In a whole-genome, dual-marker FACS-based CRISPR/Cas9 screen in primary murine CD8 T cells, we found that inactivation of the EMP24/GP25L/p24 protein family, mo...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD026984 | Pride
Pd-1 Lc-ms T-cell dysfunction Melanoma Tmed10 
ProteomicsTryptophan depletion provokes the production and presentation of in-frame tryptophan to phenylalanine substitutions
Activated T cells secrete interferon-gamma (IFN) that triggers an intra-cellular tryptophan shortage through the activation of the Indoleamine 2,3-Dioxygenase 1 (IDO1) enzyme. Surprisingly, we here show that despite tryptophan depletion, in-frame protein synthesis bypassing tryptophan codons contin...
ORGANISM(S): Homo sapiens (Human) 
2021-12-23 | PXD028921 | Pride
Cancer Tryptophan depletion Amino acid substitution Lc-ms/ms 
ProteomicsAnti-tumor immunity induces the presentation of aberrant peptides in melanoma
Many tumors escape by activating multiple cellular pathways that induce immunosuppression. One pivotal immune-suppressive mechanism is the production of tryptophan metabolites along the kynurenine pathway by IFNγ-induced IDO1 enzyme production 4-8. Phase III clinical trials using chemical inhibition...
ORGANISM(S): Homo sapiens (Human) 
2020-12-04 | PXD020224 | Pride
Immune recognition Proteomics Melanoma Tryptophan depletion Immunopeptidomics Aberrant peptides Lc-ms/ms 
UnknownUbiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling.
Not available
S-EPMC8993893 | biostudies-literature
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