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ProteomicsGlobal and protein-specific analysis reveals Nt-acetylation-independent turnover of SQE1 by Arabidopsis DOA10-like E3 ligases
The Acetylation-dependent (Ac/) N-degron pathway degrades proteins through recognition of their acetylated N-termini (Nt) by specific E3-ligases (Ac/N-recognins). To date, no Ac/N-recognins have been defined in plants. Here we use molecular, genetic, and multi-omics approaches to characterise potent...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-01-26 | PXD043217 | Pride
Erad Nt-acetylation Ac/n-degron pathway Sterol biosynthesis Proteolysis Ac/n-recognin N-terminomics 
ProteomicsA continuous assay set to screen and characterize novel protein N-acetyltransferases unveils rice GNAT2 activity
Protein N-acetyltransferases (NATs) belong to the Gcn5-related N-acetyltransferases (GNATs) superfamily. GNATs catalyze the transfer of acetyl from acetyl-CoA to the reactive amine moiety of a wide range of acceptors. NAT sequences are difficult to distinguish from other members of the GNAT superfam...
ORGANISM(S): Escherichia coli Oryza sativa (Rice) 
2022-04-04 | PXD030189 | Pride
Rice Acetylation Yeast Modifications Nata N-acetyltransferase Gnat 
ProteomicsN-Acetylation of secreted proteins is widespread in Apicomplexa and independent of acetyl-CoA transporter AT1
Acetyl-CoA critically participates in post-translational modification of proteins, central carbon and lipid metabolism in several compartments of eukaryotic cells. In mammals, the acetyl-CoA transporter 1 (AT1) facilitates the flux of cytosolic acetyl-CoA into the endoplasmic reticulum (ER) enabling...
ORGANISM(S): Toxoplasma gondii Plasmodium berghei 
2022-06-20 | PXD029616 | Pride
Acetyl-coa transporter Toxoplasma gondii Endoplasmic reticulum Acetylome Secretory pathway Plasmodium berghei 
ProteomicsAtNAA50 behaviour in the core NatA complex
In eukaryotes, the N-terminal acetylation (NTA) is one of the most frequent protein modifications. In many organisms, and especially in plants, its biological function remains a mystery. In Arabidopsis thaliana, a large part of the proteome acetylation is catalyzed co-translationally by the action o...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Escherichia coli 
2020-07-15 | PXD017430 | Pride
Naa50 Arabidopsis Rosetta Ptm N-acetyltransferase Nata Gap Acetylation N-ter 
ProteomicsArabidopsis thaliana N-terminal Acetylome
Quantitative study of the N-terminal acetylome variations in Arabidopsis thaliana, looking at the effect of a N-acetyltransferase KO.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-07-13 | PXD016496 | Pride
Nat Arbadiopsis Quantitation Acetylome N-termini Silpronaq 
ProteomicsN-terminal acetylation in Arabidopsis thaliana, and the effects of Naa10/15 or HypK knock-outs
This project is about the study of the effects of several proteins on the proteome of Arabidopsis thaliana, and more specifically on the N-terminal acetylome of this plant. To this end were analysed KO samples of either an N-alpha acetyltransferase (Naa10 or Naa15) or the chaperonne protein HypK.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-08-12 | PXD023195 | Pride
Naa15 Proteomics Arabidopsis thaliana Mass spectrometry N-terminal acetylation Hypk Naa10 
ProteomicsFast light changes promote distinct responses of plastid protein acetylation marks
Protein acetylation is a key recurring co- and posttranslational modification. How different types of acetylation respond to the same environmental stress is unknown. A member of the newly discovered family of plastid acetyltransferases (GNAT2), which is featuring both lysine- and N-terminal acetyl...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2024-08-19 | PXD040517 | JPOST Repository
ProteomicsKnock out of NAA50 in A. thaliana
Knockout of the N-acetyltransferase AtNAA50 causes severe dwarfism the model plant Arabidopsis thaliana but does not affect the activity of the essential NatA complex.
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2020-05-27 | PXD017663 | JPOST Repository
ProteomicsThe state transition acetyltransferase GNAT2 interacts with GNAT1 and GNAT3 in independent complexes
The acetylation of amino groups within proteins is one of the major posttranslational modifications (PTMs) in all organisms. N-terminal acetyltransferases (NATs) or lysine acetyltransferases (KATs) catalyze the transfer of the acetyl group from the donor substrate acetyl coenzyme A (Ac-CoA) to the t...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2024-08-19 | PXD044167 | JPOST Repository
ProteomicsGlobal profiling of acetylation reveals a new family with dual-specific lysine and N-terminal acetyltransferase activity in the plastids of Arabidopsis
Protein acetylation is a universally conserved modification occurring on N-termini (N--acetylation, NTA) and on internal lysines residues (-lysine-acetylation, KA). So far, NTA and KA were known to be supported by distinct families of enzymes (NATs and KATs, respectively), despite most of them sha...
ORGANISM(S): Escherichia Coli 
2020-07-07 | PXD015875 | JPOST Repository
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