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ProteomicsDegraders of the dengue virus capsid protein exhibit differentiated pharmacology relative to capsid inhibitors
Due to the limited size of viral genomes, most viral proteins are multifunctional; yet most direct-acting antivirals are designed as single-function inhibitors. The dengue virus (DENV) capsid protein serves as a building block for new virions while also interacting with multiple host factors to remo...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD063557 | Pride
Degrader Dengue Capsin Virus Crbn Chemical biology Protac Ubiquitin 
ProteomicsContinuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues
Small molecule-triggered protein degradation tags (degrons) are powerful tools for biology, biotechnology, and therapeutics development. Commonly used degrons, however, are large protein domains (typically >100 amino acids) that cannot be easily or cleanly installed in endogenous protein-coding gene...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD047593 | Pride
Degron Protein degradation Cereblon Phase-assisted evolution Molecular glues 
ProteomicsContinuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues
Small molecule-triggered protein degradation tags (degrons) are powerful tools for biology, biotechnology, and therapeutics development. Commonly used degrons, however, are large protein domains (typically >100 amino acids) that cannot be easily or cleanly installed in endogenous protein-coding gene...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047665 | Pride
Cereblon Phase assisted evolution Molecular glue Imid Protein degradation 
ProteomicsContinuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues
Small molecule-triggered protein degradation tags (degrons) are powerful tools for biology, biotechnology, and therapeutics development. Commonly used degrons, however, are large protein domains (typically >100 amino acids) that cannot be easily or cleanly installed in endogenous protein-coding gene...
ORGANISM(S): Homo sapiens (Human) 
2026-08-29 | PXD044978 | Pride
Protein degradation Cereblon Evolution Mg-pace Zinc finger Molecular glues 
ProteomicsContinuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues
Small molecule-triggered protein degradation tags (degrons) are powerful tools for biology, biotechnology, and therapeutics development. Commonly used degrons, however, are large protein domains (typically >100 amino acids) that cannot be easily or cleanly installed in endogenous protein-coding gene...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD044940 | Pride
Phage Cereblon Evolution Molecular glue Mg-pace Protein degradation 
ProteomicsComprehensive profiling of degrader-protein interactions
Targeted protein degradation and induced proximity both refer to advanced strategies that leverage the recruitment of target proteins to another protein to facilitate their modification, regulation or degradation. As the biological complexity of molecular glues and degraders has become increasingly ...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD054764 | Pride
Proteomics Cereblon Targeted protein degradation Molecular glue Protac Degrader Ubiquitin Imid E3 ligase 
ProteomicsDesign principles for cyclin K molecular glue degraders
Molecular glue degraders are an effective therapeutic modality, but their design principles are not well understood. Recently, several unexpectedly diverse compounds were reported to deplete cyclin K by linking CDK12-cyclin K to the DDB1-CUL4-RBX1 E3 ligase. To investigate how chemically dissimilar ...
ORGANISM(S): Hordeum vulgare (Barley) 
2023-10-20 | PXD041836 | Pride
Ubiquitin Cdk12 Molecular glue Cr8 Cyclink Degrader 
ProteomicsIKAROS and MENIN are Functionally Cooperative Therapeutic Targets in Acute Myeloid Leukemia
Genome-scale functional genetic screening was utilized to identify resistance mechanisms and synthetic lethal interactions during small molecule targeting of MENIN and DOT1L in MLL1-rearranged AML. Chromatin regulatory complexes are found to modulate the therapeutic response to these inhibitors, and...
ORGANISM(S): Homo sapiens (Human) 
2022-03-11 | PXD025227 | Pride
Ikzf1 Kmt2a Menin Mll1 Ikaros Acute myeloid leukemia Dot1l Imid Lenalidomide Men1 
ProteomicsIKAROS and MENIN are Functionally Cooperative Therapeutic Targets in Acute Myeloid Leukemia
Genome-scale functional genetic screening was utilized to identify resistance mechanisms and synthetic lethal interactions during small molecule targeting of MENIN and DOT1L in MLL1-rearranged AML. Chromatin regulatory complexes are found to modulate the therapeutic response to these inhibitors, and...
ORGANISM(S): Homo sapiens (Human) 
2022-03-11 | PXD025228 | Pride
Ikzf1 Kmt2a Menin Mll1 Ikaros Acute myeloid leukemia Dot1l Imid Lenalidomide Men1 
ProteomicsIKAROS and MENIN are Functionally Cooperative Therapeutic Targets in Acute Myeloid Leukemia
Genome-scale functional genetic screening was utilized to identify resistance mechanisms and synthetic lethal interactions during small molecule targeting of MENIN and DOT1L in MLL1-rearranged AML. Chromatin regulatory complexes are found to modulate the therapeutic response to these inhibitors, and...
ORGANISM(S): Homo sapiens (Human) 
2022-03-11 | PXD025231 | Pride
Ikzf1 Kmt2a Menin Mll1 Ikaros Acute myeloid leukemia Dot1l Imid Lenalidomide Men1 
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