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ProteomicsComparative exoproteome profiling of an invasive and a commensal Staphylococcus haemolyticus isolate
Staphylococcus haemolyticus is a skin commensal emerging as an opportunistic pathogen. Nosocomial isolates of S. haemolyticus are the most antibiotic resistant members of the coagulase negative staphylococci (CoNS), but information about other S.haemolyticus virulence factors is scarce. Bacterial vi...
ORGANISM(S): Staphylococcus haemolyticus 
2018-11-30 | PXD010389 | Pride
Staphylococcus haemolyticus Membrane vesicles Secretome. 
ProteomicsCALCOCO1 acts with VAMP-Associated Proteins to mediate ER-phagy
To explore the interaction partners of CALCOCO1, we immunoprecipitated EGFP-CALCOCO1 from HEK 293 cells’ lysate and identified the bound proteins by mass spectrometry. The identified proteins were then filtered against GFP control.
ORGANISM(S): Homo sapiens (Human) 
2020-06-02 | PXD018894 | Pride
Golgi Vapb Vapa Er-phagy Ffat motif Calcoco1 Autophagy 
ProteomicsProteomic analysis of extracellular vesicles derived from Merkel cell carcinoma cell lines
Exosomes constitute an evolutionary conserved mechanism of intercellular signaling. Their importance are gaining increasing such as prognostic and diagnostic markers, and potential therapeutic tool. Merkel cell carcinoma (MCC) is an aggressive form of skin cancer with a poor prognosis. There are not...
ORGANISM(S): Homo sapiens (Human) 
2016-08-08 | PXD004198 | Pride
Polyomavirus Cancer Exosome Proteomics Merkel cell carcinoma 
ProteomicsLarge-scale secretome analyses unveil a superior immunosuppressive phenotype from umbilical cord stromal cells compared to other adult mesenchymal stromal cells
Mesenchymal stromal cells (MSCs) with regenerative and immunomodulatory potential are being investigated as a potential therapeutic tool for cartilage lesions. MSCs express a wide variety of bioactive molecules including cytokines, trophic factors, and proteases, which act in a paracrine fashion to ...
ORGANISM(S): Homo sapiens (Human) 
2019-01-29 | PXD011762 | Pride
Chondrocytes Adult stromal cells Umbilical cord stromal cells Lfq Secretome and immunomodulation 
ProteomicsDose- and time-dependent effects of triethylene glycol dimethacrylate on the proteome of human THP-1 monocytes
Triethylene glycol dimethacrylate (TEGDMA) is commonly used in polymer resin-based dental materials. This projected investigated molecular mechanisms of TEGDMA toxicity by identifying time- and dose dependent effects on the proteome of human THP-1 monocytes. Effects of different concentrations (0.07...
ORGANISM(S): Homo sapiens (Human) 
2018-07-31 | PXD009206 | Pride
Thp1 Silac Methacrylate 
ProteomicsNIMA-related kinase 9–mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1
We found that LC3B is phosphorylated in vitro by STK3, STK4, NEK9, and PKCζ. To identify phosphorylation sites following in vitro phosphorylation, GST-LC3B was overexpressed in E. coli, purified using glutathione-Sepharose 4 Fast Flow beads and incubated in kinase assays with recombinant kinases or ...
ORGANISM(S): Homo sapiens (Human) 
2020-01-23 | PXD016681 | Pride
Microtubule-associated lc3b protein Autophagy In vitro phosphorylation 
ProteomicsImmunization with lytic polysaccharide monooxygenase CbpD induces protective immunity against Pseudomonas aeruginosa pneumonia
Bacterial lytic polysaccharide monooxygenases (LPMOs) are understudied in the context of infection disease. We demonstrated that Pseudomonas aeruginosa LPMO CbpD is a virulence determinant in pneumonia. Moreover, Mice immunized with CbpD generate robust antibody responses that provide protection aga...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-26 | PXD039298 | Pride
Cbpd Lpmo Pnemonia Pseudomonas aeruginosa 
ProteomicsProteomic analysis of extracellular vesicles derived from Merkel cell carcinoma cell lines
Exosomes constitute an evolutionary conserved mechanism of intercellular signaling. Their importance are gaining increasing such as prognostic and diagnostic markers, and potential therapeutic tool. Merkel cell carcinoma (MCC) is an aggressive form of skin cancer with a poor prognosis. There are not...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080262 | MassIVE
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