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OtherQuantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks.
Data from ProteomeXchange, PXD ID: PXD001076. Experiment: JG-N2, file: JG-N2-12.mzml. Published as part of Mol Cell Proteomics. 2014 Sep 29 . From the Abstract: {{i}} ... We used Stable Isotope of Amino acids in Culture (SILAC) combined with phosphopeptide enrichment and quantitative mass-spectrome...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320004050 | GPMDB
Resource Reanalysis 
ProteomicsQuantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks
The focus of the present study was to characterize the phosphoproteome of cytotoxic T cells and to explore the role of the serine threonine kinase PKD2 (Protein Kinase D2) in the phosphorylation networks of this key lymphocyte population. We used Stable Isotope Labelling of Amino acids in Culture (S...
ORGANISM(S): Mus musculus (Mouse) 
2014-10-03 | PXD001076 | Pride
Silac Pkd2 Phosphoproteomics Lymphocytes 
ProteomicsWhole Proteomics of 24 hr pan Pim kinase inhibitor treatment of IL2 cultured CD8 T cells
T cell antigen-receptor (TCR) and cytokine receptor engagement trigger large changes in Serine/Threonine kinase signalling networks to drive T cell activation and differentiation. The role of only few kinase signalling pathways have been studied in detail, and in this context, Pim kinases are an int...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-15 | PXD051214 | Pride
Lc-msms Pim447 Azd1208 Tofacitinib Mouse Pim1 Pim2 Cd8 t cell Cytotoxic t lymphocyte Pim kinase 
ProteomicsInterleukin-2 shapes the cytotoxic T cell proteome and immune-environment sensing
Interleukin-2 (IL-2) and Janus kinases (JAKs) regulate transcriptional programs and protein synthesis to control the differentiation of effector CD8+ cytotoxic T cells (CTL). Using high-resolution mass spectrometry, we have generated an in-depth characterisation of how IL-2 and JAKs configure the CT...
ORGANISM(S): Mus musculus (Mouse) 
2018-04-17 | PXD008112 | Pride
Proteomics Jak1 Il-2 Interleukin-2 Jak3 Lymphocytes 
ProteomicsPhosphoproteomic analyses of IL-2 signaling reveals integrated JAK-dependent and independent phosphorylation networks that drive cytotoxic T cell fate
High-resolution mass spectrometry analysis of Interleukin 2 (IL-2) and Janus kinase (JAK) controlled protein phosphorylations in cytotoxic T lymphocytes (CTL) revealed JAKs coupled IL-2 receptors to diverse and complex serine/threonine kinase-substrate networks. These involved intricate, co-ordinate...
ORGANISM(S): Mus musculus (Mouse) 
2016-08-25 | PXD004645 | Pride
Lck/fyn Lymphocytes. Silac Jak1 Il-2 Jak3 Phosphoproteomics 
ProteomicsProteomics of 24 h TCR activated wild-type and Pim1/Pim2 double knockout CD4 and CD8 T cells
T cell antigen-receptor (TCR) and cytokine receptor engagement trigger large changes in Serine/Threonine kinase signalling networks to drive T cell activation and differentiation. The role of only few kinase signalling pathways have been studied in detail, and in this context, Pim kinases are an int...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-15 | PXD051198 | Pride
Lc-msms Mouse Pim1 Pim2 T lymphocyte Pim kinase 
ProteomicsMass Spectrometry identifies temporal changes and hallmarks of Delayed Recovery in the COVID19 Neutrophil proteomes
High-resolution mass spectrometry and the parallel quantitative evaluation of thousands of proteins has been used to characterise the proteomes of peripheral blood neutrophils from >200 individuals. This work has comprehensively mapped neutrophil molecular changes associated with mild versus severe ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-17 | PXD036082 | Pride
Proteomics Long covid Dia Interferon Mass spectrometry Human Covid19 Neutrophil 
ProteomicsMass Spectrometry identifies temporal changes and hallmarks of Delayed Recovery in the COVID19 Neutrophil proteomes part2
Mass Spectrometry identifies temporal changes and hallmarks of Delayed Recovery in the COVID19 Neutrophil proteomes MTD project_description High-resolution mass spectrometry and the parallel quantitative evaluation of thousands of proteins has been used to characterise the proteomes of peripheral bl...
ORGANISM(S): Homo sapiens (Human) 
2022-08-17 | PXD036089 | Pride
Proteomics Long covid Dia Interferon Mass spectrometry Human Covid19 Neutrophil 
ProteomicsLack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development
Regulatory T (Treg) cells are essential for the maintenance of immunological tolerance, yet the molecular components required for their maintenance and effector functions remain incompletely defined. Inactivation of VPS34 in Treg cells led to an early, lethal phenotype, with massive effector T cell ...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-29 | PXD048981 | Pride
Mouse Vps34 Pi3k T cells T regs 
ProteomicsM.musculus - T cell, SC (Hukelmannetal,natimmunol2016)
abundance based on Spectral counting, Interaction consistency score: 16.2, Coverage: 30
ORGANISM(S): 10090 
2016-00-00 | 190918057 | PAXDB
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