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ProteomicsCD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects
CD137 (4-1BB) is a member of the TNFR family that mediates potent T-cell costimulatory signals upon ligation by CD137L or agonist monoclonal antibodies. CD137 agonists attain immunotherapeutic antitumor effects in cancer mouse models and multiple agents of this kind are undergoing clinical trials. W...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042585 | Pride
4-1bb Smac mimetic compounds Cd137 Ciap1 Ciap2 Immunotherapy 
ProteomicsProteomic profiling and characterization of differential allergens in the nematodes Anisakis simplex sensu stricto and A. pegreffii
The parasite species complex Anisakis simplex sensu lato (Anisakis simplex sensu stricto; (A. simplex s.s.), A. pegreffii, A. simplex C) is the main cause of severe anisakiasis (allergy) worldwide and is now an important health matter. In this study, the relationship of this Anisakis species complex...
ORGANISM(S): Anisakis simplex 
2014-07-11 | PXD000662 | Pride
Nematoda Anisakis Proteomics Allergens 
ProteomicsUnravelling the initial triggers of Botrytis cinerea infections. Botrytis cinerea surfactome
Botrytis cinerea, the causal agent of the gray mold, is one of the most important phytopathogenic fungi due to its ability to affect more than 1400 cultivable vegetal species. Signal transduction cascades mediate the dialogue between the environment, the plant and the fungus, which is essential in t...
ORGANISM(S): Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea) 
2022-02-17 | PXD028958 | Pride
Botrytis cinerea Virulence factor and pathogenicity factor Surfactome Shaving Proteome 
ProteomicsProteomic snapshot of saliva samples reveals new pathways implicated in SARS-CoV-2 pathogenesis
Variations in the susceptibility to SARS-CoV-2 infection and risk of severe disease are yet not well understood. The information on the human pathways and active members of the microbiome that can affect SARS-CoV-2 susceptibility and disease progression in the saliva is very scarce. Here, we studied...
ORGANISM(S): Homo sapiens (Human) 
2024-05-31 | PXD032333 | Pride
Functional analysis Proteomics Sars-cov-2 Saliva Pathogenesis 
ProteomicsTime-based quantitative proteomic and phosphoproteomic analysis of A549-ACE2 cells during SARS-CoV-2 infection
The outbreak of COVID-19, a disease caused by severe acute respiratory syndrome coronavirus 2, led to an ongoing pandemic with devastating consequences for the global economy and human health. With the globalspread of SARS-CoV-2, multidisciplinary initiatives were launched to explore new diagnostic,...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053240 | Pride
Proteomics Virus-host interaction Sars-cov-2 Covid-19 
ProteomicsPersulfidated subproteome reveals the regulation of protein function by hydrogen sulfide in diverse biological processes and nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase in plants.
Hydrogen sulfide-mediated signaling pathways regulates many physiological andpathophysiological processes in mammalian and plant systems. The molecular mechanism bywhich hydrogen sulfide exerts its action involves the oxidative post-translational modificationof cysteine residues to form a persulfida...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2017-10-27 | PXD005168 | Pride
Arabidopsis Hydrogen sulfide Gapdh Postranslational modification Nuclear localization S-sulfhydration 
ProteomicsIdentification of host PDZ-based interactions with SARS-CoV-2 E protein in human monocytes
PDZ (Post-synaptic density, PSD-95)/ Disc large, Dlg/ Zonula occludens, ZO-1) proteins are central in the assembly of multiprotein signalling complexes that are formed in distinctive, specialized cell regions. In these complexes different signals are orchestrated and traduced into quick and efficien...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042620 | Pride
Viral targeting Sars-cov-2 Macrophage Innate immune response Syntenin Zo-2 Pdz Monocyte Il-16 Coronavirus Envelope e protein 
ProteomicsMyosin-9 is required for lysosome-mediated nonlytic reovirus egress
Mammalian orthoreoviruses (reoviruses) are nonenveloped, double-stranded RNA viruses that assemble progeny particles in cytoplasmic viral factories (VFs) and exit some types of cells using a nonlytic release mechanism. In human brain microvascular endothelial cells (HBMECs), progeny reovirus virions...
ORGANISM(S): Homo sapiens (Human) Orthoreovirus 
2025-10-10 | PXD068971 | Pride
Reovirus  virus egress  myosin-9  proteomics  imaging 
ProteomicsQuantitative Proteomics comparison of total expressed proteomes of Anisakis simplex sensu stricto, A. pegreffii and their hybrid genotype
The total proteomes of Anisakis simplex s.s., A. pegreffii and their hybrid genotype have been compared by quantitative proteomics (iTRAQ approach), which considers the level of expressed proteins. A total of 1,976 proteins have been identified using public databases. One hundred ninety six proteins...
ORGANISM(S): Anisakis simplex complex 
2020-08-17 | PXD019289 | Pride
Secretion Proteomics Oesphageal glands Excretion Anisakis simplex Allergens 
ProteomicsCommon and strain-specific post-translational modifications of the potyvirus Plum pox virus coat protein in different hosts
Phosphorylation and O-GlcNAcylation are widespread post-translational modifications (PTMs) often sharing protein targets. Numerous studies have reported phosphorylation of plant virus proteins. In plants, research on O-GlcNAcylation lags behind regarding other eukaryotes and information about O-GlcN...
ORGANISM(S): Plum pox virus 
2020-05-27 | PXD017780 | Pride
Capsid protein  o-glcnacylation  phosphorylation  sharka  potyvirus 
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