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ProteomicsA ubiquitinome analysis to study the functional roles of the proteasome associated deubiquitinating enzymes USP14 and UCH37
The removal of (poly)ubiquitin (Ub) chains at the proteasome is a key step in the protein degradation pathway that determines which proteins are degraded and ultimately decides cell fate. Specific polyubiquitin linkages may lead to distinct cellular effects, with several linkage types associated wit...
ORGANISM(S): Homo sapiens (Human) 
2022-06-30 | PXD030714 | Pride
Ubiquitinome Ubiquitinomics Silac Quantitative mass spectrometry Usp14 Parallel reaction monitoring Proteasome Deubiquitinase (dub) Ubiquitin Uch37/uchl5 
ProteomicsOncogene EVI1 Drives Acute Myeloid Leukemia Via a Targetable Interaction with CTBP2
Acute myeloid leukemia (AML) driven by the activation of EVI1 due to chromosome 3q26/MECOM rearrangements is incurable with current chemotherapy regimens. Insight into the mechanism by which EVI1 drives myeloid transformation is needed to target EVI1 in those leukemias. Here we demonstrate recurre...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD048760 | Pride
Ctbp2 Evi1 Acute myeloid leukemia 
ProteomicsOncogene EVI1 Drives Acute Myeloid Leukemia Via a Targetable Interaction with CTBP2
Acute myeloid leukemia (AML) driven by the activation of EVI1 due to chromosome 3q26/MECOM rearrangements is incurable with current chemotherapy regimens. Insight into the mechanism by which EVI1 drives myeloid transformation is needed to target EVI1 in those leukemias. Here we demonstrate recurre...
ORGANISM(S): Homo sapiens (Human) 
2023-07-13 | PXD043333 | Pride
Ctbp2 Acute myeloid leukemia (aml) Evi1 Interactomics 
ProteomicsTargeted proteomics as a tool to detect SARS-CoV-2 proteins in clinical specimens
The rapid, sensitive and specific detection of SARS-CoV-2 is critical in responding to the current COVID-19 outbreak. Here, we explore the potential of targeted mass spectrometry based proteomics for the detection of SARS-CoV-2 proteins in both research and clinical samples. First, we assessed the l...
ORGANISM(S): Homo sapiens (Human) Cercopithecus aethiops (Green monkey) (Grivet) 
2021-10-26 | PXD025294 | Pride
Ncap) Sars-cov-2 Nucleocapsid protein (np Prm Lc-ms Clinical specimen Limit of detection Parallel reaction monitoring Targeted mass spectrometry Covid-19 Aqua 
ProteomicsC. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repairC. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair.
The 10-subunit TFIIH complex is vital to transcription and nucleotide excision repair. Hereditary mutations in its smallest subunit, TTDA/GTF2H5, cause a photosensitive form of the rare developmental disorder trichothiodystrophy. Some trichothiodystrophy features are thought to be caused by subtle t...
ORGANISM(S): Caenorhabditis elegans 
2021-11-19 | PXD029008 | Pride
Transcription C. elegans Ip-ms Dna repair Tfiih 
ProteomicsUSP7, a protein involved in Hao-Fountain syndrome, controls neuronal differentiation via BCOR-ncPRC1.1
Pathogenic variants in the ubiquitin-specific protease 7 (USP7) gene cause a neurodevelopmental disorder called Hao-Fountain syndrome. However, which of its pleiotropic substrates are relevant for neurodevelopment is undetermined. Here, we present a combination of quantitative proteomics, transcript...
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD051616 | Pride
Usp7 Prm Dia-ms Label free quantitative proteomics Neuronal differentiation Bcor Hao-fountain syndrome 
ProteomicsDDA1, a novel factor in transcription-coupled repair, modulates CRL4CSA dynamics at DNA damage-stalled RNA polymerase II
Transcription–blocking lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), which removes a broad spectrum of DNA lesions to preserve transcriptional output and thereby cellular homeostasis to counteract aging. TC-NER is initiated by the physical stalling o...
ORGANISM(S): Homo sapiens (Human) 
2024-05-31 | PXD045415 | Pride
Dna damage-stalled rna polymerase ii Transcription-coupled repair Crl4csa dynamics Dda1 
ProteomicsCaldendrin regulates spine apparatus localization through myosin V-dependent ER-stabilization in dendritic spines
Excitatory synapses of principal hippocampal neurons are frequently located on dendritic spines. The dynamic strengthening or weakening of individual inputs results in a great structural and molecular diversity of dendritic spines. Active spines with large Ca2+-transients are frequently invaded by a...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2022-01-27 | PXD029427 | Pride
Spine apparatus Myosin V-dependent er-stabilization Caldendrin Dendritic spines 
ProteomicsTCR-engineered T-cells directed against Ropporin-1 constitute a safe and effective treatment for triple-negative breast cancer in near-clinical models
Triple-negative breast cancer (TNBC) shows an urgent need for new therapies. We discovered Ropporin 1 (ROPN1) as a target to treat TNBC with T-cells. ROPN1 showed high and homogenous expression in 90% of primary and metastatic TNBC but not in healthy tissues. HLA-A2-binding peptides were detected v...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054804 | Pride
Adoptive t-cell therapy  cross-reactivity  epitopes  gene-engineering  immunopeptidomics  ropporin-1  t-cell receptor  triple negative breast cancer  tumor-restricted antigen 
ProteomicsBlood-resident macrophages safeguard blood and vessel integrity
Macrophages are essential in immune defence, tissue development, and disease onset and progression. Their function is in part dictated by their microenvironment and origin. Tissue-resident macrophages originate from yolk sac progenitors, persisting in adult organs and tissues mainly through self-ren...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2026-03-11 | PXD052344 | Pride
Blood-resident macrophages 
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