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ProteomicsStructure of a volume-regulated heteromeric LRRC8A/C channel
Volume-regulated anion channels participate in the cellular response to osmotic swelling. These membrane proteins are heteromers of LRRC8 family members whose composition determines permeation properties. Although structures of the obligatory LRRC8A subunit have previously defined the architecture o...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-01-03 | PXD035350 | Pride
Lrrc8 Cryo-em Affinity purification Prm Human X-ray chrystallography Exploris 480 Volume-regulated anion channels Nanobody 
ProteomicsGephyrin interactome from mouse brain lysates using anti-gephyrin antibody and anti-gephyrin DARPins
In order to understand the protein interactors of the inhibitory synaptic scaffolding protein gephyrin, we precipitated gephyrin protein complexes from adult mouse brain lysates of both sexes using both a commercial anti-gephyrin antibody (clone 3B11), as well as anti-gephyrin Designed Ankyrin Repea...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-01 | PXD033641 | Pride
Ap-ms Mus musculus 3b11 C56bl/6j mouse Gephyrin Gphn Designed ankyrin repeat domain Darpin Interactome Lc-ms/ms 
ProteomicsThe secretome features associated with the development of re-sistance to vemurafenib in BRAFV600E mutated colon cancer cells
Patients with metastatic colorectal cancer (mCRC) carrying BRAFV600E mutation have worse response to chemotherapy and poor prognosis. The aim of this study was to conduct for the first time comparative proteomics profiling of the secretome from vemurafenib-sensitive vs. resistant colon cancer cells ...
ORGANISM(S): Homo sapiens (Human) 
2023-04-29 | PXD039766 | Pride
Brafv600e Braf inhibition Hspa5/ grp78 Colon cancer Rpa1 Er stress Vemurafenib Secretome Chemoresistance Dna replication Lc-ms/ms 
Proteomicso Exploring dynamics of pre-germinative metabolism in Medicago truncatula seeds during priming, dry-back, and post-priming imbibition using proteomics
o The dramatic impact of climate change poses a demanding challenge: the need to enhance seed quality by designing tailored seed priming protocols. Proteomics can provide a comprehensive picture of the molecular players behind the seed response to priming. Using label-free protein quantification wit...
ORGANISM(S): Medicago truncatula var. truncatula 
2023-07-10 | PXD031336 | Pride
Medicago truncatula Seeds Lc-ms/ms 
ProteomicsThe effect of the production system on the proteomics profiles of the Longissimus thoracis muscle in Arouquesa cattle
Arouquesa breed is an autochthonous Portuguese breed produced under a traditional mountain system. It is known for its Arouquesa PDO beef, a high-quality product with valued organoleptic characteristics. There is a need to improve production systems without affecting beef quality. The aim of this wo...
ORGANISM(S): Bos taurus (Bovine) 
2024-08-08 | PXD048338 | Pride
Shotgun proteomics Beef quality Differentially abundant proteins Autochthonous beef breeds Environmental sustainability 
ProteomicsEzrin inhibition overcomes acquired resistance to vemurafenib in BRAFV600E-mutated colon cancer and melanoma cells in vitro
In spite of the advancements in targeted therapy for BRAFV600E-mutated metastatic colorectal cancer (mCRC), the development of resistance to BRAFV600E inhibition limits the response rate and durability of the treatment. Better understanding of the resistance mechanisms to BRAF inhibitors will facili...
ORGANISM(S): Homo sapiens (Human) 
2023-08-29 | PXD042499 | Pride
Ezrin Brafv600e Actin cytoskeleton Nsc305787 Colon cancer Ezrin inhibitor Melanoma Braf inhibitor Vemurafenib 
ProteomicsMouse and rat liver and liver cell line LC-MS/MS
This study sought to interrogate the effects of lipids and lipid metabolites on the hepatic proteome. Protein expression and tyrosine phosphorylation in high-fat diet (HFD) mouse livers vs. livers of normal chow fed (NC) mice were investigated using multiplexed quantitative LC-MS/MS (TMT labeling). ...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2019-07-08 | PXD011458 | Pride
Mouse Rat Free fatty acids Liver Phosphotyrosine Lc-ms/ms Diabetes 
ProteomicsMouse liver expression additional replicates
This study sought to interrogate the effects of lipids and lipid metabolites on the hepatic proteome. Protein expression in high-fat diet (HFD) mouse livers vs. livers of normal chow fed (NC) mice were investigated using multiplexed quantitative LC-MS/MS (TMT labeling). This experiment contains addi...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-08 | PXD013815 | Pride
Mouse Liver Expression High-fat diet Lc-ms/ms 
ProteomicsIdentification of carcinogenesis and tumor progression processes in pancreatic ductal adenocarcinoma using high-throughput proteomics
Pancreatic adenocarcinoma (PDAC) is an aggressive disease with an overall 5 year-survival rate of just 5%. A better understanding of both the carcinogenesis processes and the mechanisms of progression of PDAC disease is mandatory. For this, proteomics data from FFPE samples of 173 primary tumor, nor...
ORGANISM(S): Homo sapiens (Human) 
2022-06-21 | PXD032076 | Pride
Ffpe Pancreatic ductal adenocarcinoma Huamn Linear mixed model Lymph node Pdac Metastasis 
ProteomicsUtility of CYP2D6 copy number variants as prognostic biomarker in localized anal squamous cell carcinoma
Anal squamous cell carcinoma (ASCC) is an infrequent tumor. Since 70s, treatment of stages II-III consists on a combination of 5-fluorouracil (5FU), mitomycin C (MMC), and radiotherapy. The aim of this study is the identification of biomarkers that allow personalized treatment and improvement of the...
ORGANISM(S): Homo sapiens (Human) 
2023-04-26 | PXD037816 | Pride
Ascc Dia Anal squamous cell carcinoma Ffpe Radiotherapy 5fu Mmc Lc-ms/ms 
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