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ProteomicsDynarrestin, a novel inhibitor of cytoplasmic dyneins 1 and 2
Aberrant hedgehog (Hh) signaling contributes to the pathogenesis of multiple cancers. Currently available inhibitors target Smoothened, which can acquire mutations causing drug resistance. Thus, compounds that inhibit Hh signaling downstream of Smoothened are urgently needed. We identified dynarrest...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-08 | PXD004440 | Pride
Hedgehog signalling Small molecule inhibitor Dynein Dynarrestin 
ProteomicsDissecting the mechanism of signaling-triggered nuclear export of newly synthesized influenza virus ribonucleoprotein complexes
Influenza viruses (IV) exploit a variety of signaling pathways. Previous studies showed that the Raf/MEK/ERK pathway is functionally linked to nuclear export of viral ribonucleoprotein (vRNP) complexes, suggesting that vRNP export is a signaling induced event. However, the underlying mechanism remai...
ORGANISM(S): Homo sapiens (Human) Influenza A virus (A/Wilson-Smith/1933(H1N1)) 
2020-06-18 | PXD016638 | Pride
Kinase signalling Proteomics Influenza virus Mass spectrometry Phosphorylation Vrnp complex Vrnp export 
ProteomicsNovel role of TrkC in diabetic nephropathy and cross-talk of TrkC with insulin-related signaling
Diabetic nephropathy is a major cause of end-stage renal disease. Kidney podocytes play a central role in the pathogenesis of diabetic nephropathy. With their intercellular contacts they assemble part of the kidney filter. Many molecular mechanisms of the pathogenesis of diabetic nephropathy are not...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD017960 | Pride
Podocyte Mass spectrometry Neurotrophin Ntf3 Trkc Phosphoproteomics Diabetic nephropathy 
ProteomicsThe footprint of embryonic genome activation on the proteome of mouse preimplantation development
The transformation of a fertilized oocyte into a multicellular embryo comprised of differentiated cells depends on the processing of genetic orders, first in the form of transcripts and then of proteins. Our current understanding of mouse development has greatly benefited from the analysis of transc...
ORGANISM(S): Mus musculus (Mouse) 
2019-10-23 | PXD007082 | Pride
Lc-msms Mouse development Silac Preimplantation Oocyte 
ProteomicsMouse aging oocyte proteome comparison
Here we asked if oocyte proteomes are representative of the transcriptomes, how the abundance of specific genes’ mRNA and protein responds to maternal aging, and if oocyte aging presents the features characteristic of somatic aging. To address these questions on the proteomic level, we employed stab...
ORGANISM(S): Mus musculus (Mouse) 
2016-10-14 | PXD000512 | Pride
Mus musculus Embryonal carcinoma cells Spike-in Silac Oocyte 
ProteomicsA balanced Oct4 protein interaction network is crucial for maintaining pluripotency
Oct4 is considered a master transcription factor for pluripotent cell self-renewal and embryo development. It primarily collaborates with other transcriptional factors or coregulators to maintain pluripotency. However, it is still unclear how Oct4 interacts with its partners. Here, we show that the ...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-10 | PXD017456 | Pride
Oct4 Embryonal development Proteomics Pluripotency Mass spectrometry Transcription factor Pou5f1 Stem cells Protein-protein interaction 
ProteomicsVascular endothelial protein tyrosine phosphatase: Identification of novel cell junction-related substrates and a ternary receptor complex with EPHB4 and TIE2
Vascular endothelial protein tyrosine phosphatase (VE-PTP, PTPRB) is a receptor type phosphatase that is crucial for the regulation of endothelial junctions and blood vessel development. VE-PTP regulates vascular integrity by dephosphorylating substrates which are key players in endothelial junction...
ORGANISM(S): Mus musculus (Mouse) 
2019-08-20 | PXD011940 | Pride
Lc-msms Mouse Tyrosine phosphatase Endothelial cells Substrate trapping 
ProteomicsDifferences in oocyte composition anticipate differences in embryo quality: a proteomic study in inbred mice
Current models of early development assign major roles to stochastic processes and epigenetic regulation, whose influence is considered to outweigh the genetic differences that exist between individuals. However, epigenetic agents are ultimately encoded by genes. It follows that the variable endowme...
ORGANISM(S): Mus musculus (Mouse) 
2015-01-28 | PXD001059 | Pride
Lc-msms Mouse Oocytes Reprograming 
ProteomicsThe integrin linked kinase is required for chemokine-triggered high affinity conformation of the leukocyte β2-integrin LFA-1The integrin linked kinase is required for chemokine-triggered high affinity conformation of the leukocyte β2-integrin LFA-1
Invasion of leukocytes, including neutrophils, in response to injury or infection relies on the orchestrated activation of integrins. The neutrophil integrin lymphocyte function-associated antigen-1 (LFA-1) has been implicated in the regulation of leukocyte adhesion by binding to ICAM-1 expressed on...
ORGANISM(S): Homo sapiens (Human) 
2020-07-20 | PXD017088 | Pride
Lc-msms Proteomics Integrins Mass spectrometry Neutrophils Phosphoproteomics Immunology 
ProteomicsThe ubiquitin landscape of the Influenza A Virus polymerase
During influenza A virus (IAV) infections, viral proteins are targeted by cellular E3 ligases for modification with ubiquitin. Here, we decipher and functionally explore the ubiquitin landscape of the IAV polymerase during infection of human alveolar epithelial cells by applying mass spectrometry an...
ORGANISM(S): Homo sapiens (Human) Influenza A virus (A/Wilson-Smith/1933(H1N1)) 
2023-03-11 | PXD030816 | Pride
Influenza a virus Pb1 Affinity enrichment Pa Viral rna-dependent rna polymerase Ubiquitination K-ε-gg motif Lc-msms Pb2 
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