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ProteomicsProteomics of of SLC25A1 and SLC25A4 null cells using TMT
Faundez TMT 12 samples - 2 batches with 24 fractions each
ORGANISM(S): Homo sapiens (Human) 
2023-05-31 | PXD017501 | Pride
Human tmt 
ProteomicsActivity-Dependent Mitochondrial Plasticity and Mitoproteome are Dysregulated in Fragile X Syndrome
We measure changes in the proteome after 48 hours of activity deprivation with tetrodotoxin (TTX) and the NMDA receptor antagonist (2R)-amino-5-phosphonovaleric acid (APV). We used wild type and FMRP mutant primary cortical neurons treated with vehicle or treated with TTX-APV.
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD021473 | Pride
Autism Fmrp Mitochondria Homeostatic plasticity Fmr1 Fragile x syndrome Mitoproteome 
ProteomicsThe Mitochondrial RNA Granule is Necessary for Parkinsonism-Associated Metal Toxicity
We measured the proteome of wild type HAP1 cells and cells mutant for the manganese transporter SLC30A10, PARK2, and the ADP-ATP mitochondrial translocator SLC25A4.
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD030502 | Pride
Mitochondrial transcriptome Park2 Manganism Mitochondria Rna granule Slc30a10 Parkinson's 
ProteomicsFaundez Comparison of 2 Cell lines (Hek and Hep)
Comparison of 2 cell lines by TMT fractionation mass spectrometry
ORGANISM(S): Homo sapiens (Human) 
2023-05-31 | PXD038974 | Pride
Hek and hep cells lines 
ProteomicsMitochondrial Proteostasis Requires Genes Encoded in a Neurodevelopmental Syndrome Locus
Eukaryotic cells maintain proteostasis through mechanisms that require cytoplasmic and mitochondrial translation. Genetic defects affecting cytoplasmic translation perturb synapse development, neurotransmission, and are causative of neurodevelopmental disorders such as Fragile X syndrome. In contras...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025289 | Pride
Faims Orbitrap Lc-msms 
ProteomicsConvergent Cerebrospinal Fluid Proteomes and Metabolic Ontologies in Humans and Animal Models of Rett Syndrome
We measured the proteome of wild type and Mecp2 KO rat cerebral cortex, hippocampus and cerebrospinal fluid of animals aged 25 days postnatal age. We measured the proteome of human cerebrospinal fluid from Rett syndrome patients before and after treatment with recombinant IGF-1. We measured the pr...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2022-10-14 | PXD030426 | Pride
Rna processing Manganese Parkinson's disease Parkinsonism Manganism Park2 Slc30a10 
ProteomicsCdh1 (Fzr1) Interactome in Neuroblastoma (N2A) cells
In this study, we wanted to explore the protein interactors of Cdh1, a subunit of the E3 Ubiquitin-Ligase Cdh1-APC. Our data show that in addition to interacting with other components of the Cdh1-APC complex, Cdh1 interacts with regulators of translation.
ORGANISM(S): Mus musculus (Mouse) 
2020-04-29 | PXD018875 | Pride
Ubiquitination Cdh1 Protein synthesis Fzr1 
ProteomicsHeterogeneous Expression of Nuclear Encoded Mitochondrial Genes Distinguishes Inhibitory and Excitatory Neurons.
Mitochondrial composition varies by organ and their constituent cell types. This mitochondrial diversity likely determines variations in mitochondrial function. However, the heterogeneity of mitochondria in the brain remains underexplored despite the large diversity of cell types in neuronal tissue....
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD026104 | Pride
Mitochondria Proteomics Tmt Neurons Lc-ms/ms 
ProteomicsTMT mass spectrometry analysis of wild type and Mecp2 null rat CSF of animals aged 23-26 days
TMT mass spectrometry analysis of wild type and Mecp2 null rat CSF of animals aged 23-26 days
ORGANISM(S): Rattus norvegicus (Rat) 
2022-10-14 | PXD029808 | Pride
Rat Tmt Csf 
ProteomicsTMT mass spectrometry analysis of wild type and Mecp2 null mouse CSF of animals aged 46 days
TMT mass spectrometry analysis of wild type and Mecp2 null mouse CSF of animals aged 46 days
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD029809 | Pride
Mouse Tmt Csf 
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