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ProteomicsFast skeletal myosin binding protein-C regulates fast skeletal muscle contraction
Myosin-binding protein C (MyBP-C) is a thick filament regulatory protein found exclusively in the C-zone of the A band in the sarcomeres of vertebrate striated muscle. Cardiac, slow skeletal and fast skeletal MyBP-C (fMyBP-C) paralogs perform different functions. However, the functional role of fMyB...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-09 | PXD022316 | Pride
Lc ms/ms Proteomics Skeletal myosin binding protein-c Muscle 
UnknownControversial Role of Transferrin in the Transport of Ruthenium Anticancer Drugs.
Not available
S-EPMC9496346 | biostudies-literature
ProteomicsPRM analysis of phosphopeptides of Nab2, Foxk1, HURP, ERK1/2, NPM, and Hspa4 from ΔB-Raf:ER cells.
ΔB-Raf:ER cells were treated with U0126 or 4-HT for 30 min in four biological replicates. Total proteins from cell lysates were digested with Typsin/Lys-C mix, and phosphopeptides were enriched by IMAC using Fe-NTA columns. After data-dependent LC-MS/MS analysis, phosphopeptides of Nab2, Foxk1, HURP...
ORGANISM(S): Mus Musculus (mouse) 
2022-03-03 | PXD028826 | JPOST Repository
ProteomicsA Spatiotemporal Map of Co-Receptor Signaling Networks Underlying B Cell Activation
The B cell receptor (BCR) signals together with a multi-component co-receptor complex to initiate B cell activation in response to antigen binding. This process underlies nearly every aspect of proper B cell function. Here, we take advantage of peroxidase-catalyzed proximity labeling combined with q...
ORGANISM(S): Homo sapiens (Human) 
2024-06-06 | PXD040262 | Pride
Systems immunology Proteomics Bcr signaling B cell co-receptor B cells Phosphoproteomics 
ProteomicsNse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding
Eukaryotic cells employ three SMC complexes to control DNA folding and topology. The Smc5/6 complex plays roles in DNA repair and in preventing the accumulation of deleterious DNA junctions. To elucidate how specific features of Smc5/6 govern these functions, we reconstituted the yeast holo-complex....
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-07-02 | PXD024160 | Pride
Atpase Condensin Loop extrusion Chromosome segregation Xl-ms Smc5 Smc Smc6 Genome maintenance Cohesin 
UnknownEvaluate the Antigenotoxicity and Anticancer Role of β-Sitosterol by Determining Oxidative DNA Damage and the Expression of Phosphorylated Mitogen-activated Protein Kinases', C-fos, C-jun, and Endothelial Growth Factor Receptor.
Not available
S-EPMC5307922 | biostudies-literature
UnknownTargeted cleavage of HIV RRE RNA by Rev-coupled transition metal chelates.
Not available
S-EPMC3387528 | biostudies-literature
ProteomicsTBK1 interacts with tau and enhances neurodegeneration in tauopathy
One of the defining pathological features of Alzheimer’s Disease (AD) is the deposition of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau in the brain. Aberrant activation of kinases in AD has been suggested to enhance phosphorylation and toxicity of tau, making the responsible t...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD025301 | Pride
Coip Ikk Tbk1 mapt tau phosphorylation 
ProteomicsPKA-Independent Vasopressin Signaling in Renal Collecting Duct
Vasopressin regulates renal water excretion by binding to the Gs-coupled vasopressin receptor (V2R) in collecting duct cells, resulting in cyclic AMP-dependent increases in epithelial water permeability through regulation of the aquaporin-2 (AQP2) water channel. Our prior studies showed that CRISPR...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-05 | PXD015719 | Pride
Mpkccd Phosphoproteomics Ampk Silac Prm-ms 
ProteomicsDDX21 is a p38-MAPK sensitive nucleolar protein necessary for mouse preimplantation embryo development and cell-fate specification
2-cell (E1.5) stage embryos were cultured in normal KSOM+AA conditions until E3.5 +2h and thereafter 100 embryos each were moved to control or p38-MAPKi conditions and cultured for another 7 hours (E3.5 +9h). The embryos were then washed through pre-warmed (37˚C) Hank’s balanced salt solution (HBSS,...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-12 | PXD025754 | Pride
Lc-msms Preimplantation embryo development Ddx21 Cell fate specification P38-mapk 
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