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ProteomicsVPS18 Deficiency Leads to a Neutrophil Maturation Defect Associated with Disturbed Vesicle Homeostasis
: Neutrophils, the first cells to arrive at the site of inflammation, are rather short-lived cells and thus have to be constantly replenished. During neutrophil development, vesicle dynamics need to be fine-tuned and impaired vesicle trafficking has been linked to failure in neutrophil maturation. H...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-28 | PXD049111 | Pride
Proteomics Ms Neutrophils 
UnknownValidation of commercial Mas receptor antibodies for utilization in Western Blotting, immunofluorescence and immunohistochemistry studies.
Not available
S-EPMC5558983 | biostudies-literature
ProteomicsTDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons
Whole proteome quantification identified upregulation of the ESCRT component VPS4B upon TDP-43 knockdown in neurons.
ORGANISM(S): Rattus norvegicus (Rat) 
2016-09-29 | PXD004756 | Pride
Ftld Recycling endosomes Tdp-43 Als Erbb4 
ProteomicsCell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation
Cell-selective proteomics is emerging as a powerful concept for studying heterocellular processes. However, its potential to dissect intercellular signaling has not been exploited, despite its promise to identify non-cell autonomous disease mechanisms or biomarkers. Here, we devised an improved azi...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-08-15 | PXD018659 | Pride
Proteomics Cell-selective Azidonorleucine Secretomics Serum Mouse Tumor Lc-msms Pdac Pancreatic cancer Extracellular matrix 
ProteomicsCell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation
Cell-selective proteomics is emerging as a powerful concept for studying heterocellular processes. However, its potential to dissect intercellular signaling has not been exploited, despite its promise to identify non-cell autonomous disease mechanisms or biomarkers. Here, we devised an improved azid...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2023-07-20 | PXD040084 | Pride
Submitter keyword: lc-msms Proteomics Cell-selective Azidonorleucine Secretomics Serum Mouse Tumor Pdac Pancreatic cancer Extracellular matrix 
ProteomicsA mass spectrometry guided pre-clinical funnel for the identification of novel vaccine candidates against Helicobacter pylori
We established a generic pipeline for the identification of surface-exposed vaccine candidates in gram-negative bacteria. Using Helicobacter pylori as a model organism, our approach combines design of experiment driven surface shaving with quantitative mass spectrometry to identify 22 highly conserv...
ORGANISM(S): Helicobacter pylori J99 (Campylobacter pylori J99) 
2019-11-11 | PXD012566 | Pride
Proteomics Vaccine Surfome Helicobacter pylori 
ProteomicsC9ORF72 interaction with cofilin modulates actin dynamics in motoneurons
Intronic hexanucleotide expansions in C9ORF72 are common in ALS and FTLD, but it is unknown whether loss of function, toxicity by the expanded RNA or dipeptides from non ATG-initiated translation are responsible for the pathophysiology. We determined the interactome of C9ORF72 in motoneurons and fou...
ORGANISM(S): Mus musculus (Mouse) 
2016-09-30 | PXD004913 | Pride
Ftld Cofilin Als C9orf72 
ProteomicsLandscape of protein-protein-interactions during hepatitis C virus assembly and release
Assembly of infectious hepatitis C virus (HCV) particles requires multiple cellular proteins including for instance apolipoprotein E (ApoE). To describe these protein-protein-interactions, we performed an affinity purification mass spectrometry screen (AP-MS) of HCV infected cells. We used functiona...
ORGANISM(S): Homo sapiens (Human) 
2023-12-18 | PXD046941 | Pride
Virus host interaction Ap-ms Hepatitis c virus Virus assembly Hcv 
ProteomicsPD-1-targeted immunotherapy in NASH-triggered liver cancer induces pro-tumorigenic environment through CD8+PD-1+ T-cells
Immunotherapy has opened hitherto unknown possibilities to treat cancer. Whereas some cancer types (e.g. melanoma) can be efficiently treated, others lack measurable positive effects (e.g. PDAC). Moreover, stratification of responders/non-responders is only possible in some cancer types (e.g. melano...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-03 | PXD017236 | Pride
Immunotherapy Cd8+pd1+ Nash 
ProteomicsCombinatorial high throughput drug screening identifies a synergistic drug interaction that sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade
KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) is highly immunosuppressive and resistant to targeted therapies, immune checkpoint blockade and engineered T cells. Here, we performed a systematic high throughput combinatorial drug screen and identified a synergistic interaction between the MEK i...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-11 | PXD027877 | Pride
Proteomics Combination therapy Immune checkpoint inhibition Mass spectrometry Pancreatic cancer 
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