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ProteomicsBudding yeast relies on qualitative G1 cyclin specificity to couple cell cycle progression with morphogenetic development
Two models have been put forward for cyclin-dependent kinase (Cdk) control of the cell cycle. In the qualitative model, cell cycle events are ordered by distinct substrate specificities associated with successive waves of G1, S and mitotic cyclins. Alternatively, the gradual quantitative rise of Cdk...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-08-23 | PXD022757 | Pride
Lc-ms/ms Tmt Cdk Yeast Cyclin Cell cycle Phosphoproteomics Cyclin-dependent kinase 
ProteomicsOxonium ion scanning mass spectrometry for large-scale plasma glycoproteomics
Protein glycosylation, a complex and heterogeneous post-translational modification that is frequently dysregulated in disease, has been difficult to analyse at scale. Here we report a data-independent acquisition technique for the large-scale mass-spectrometric quantification of glycopeptides in pla...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-29 | MSV000089567 | MassIVE
ProteomicsULK1/2 DKO MEF phosphoproteomics
Autophagy is a mechanism by which intracellular cargo are catabolised in the lysosome. It involves the formation of double membraned organelles termed autophagosomes, a complex process orchestrated by the serine/threonine kinase ULK complex and class III PI3 kinase VPS34. Unbiased screens for ULK su...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-15 | PXD022228 | Pride
Phosphoproteomics Vps15 Vps34 P150 Pi3 kinase Autophagy Lc-ms/ms Pik3r4 Autophagosome Prkag2 Ulk2 Tmt Ulk1 Silac Amino acid starvation Mouse embryonic fibroblasts Orbitrap ulk1 
ProteomicsPlasmodium falciparum protein phosphatase PP7 is required for early ring-stage development
We previously reported that the Plasmodium falciparum putative serine/threonine protein phosphatase 7 (PP7) is a high confidence substrate of the cAMP-dependent protein kinase (PKA). Here we explore the function of PP7 in asexual P. falciparum blood stage parasites. We show that conditional disrupti...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2024-10-07 | PXD051277 | Pride
Apicomplexan parasites Signal transduction Calcium signaling Malaria Serine/threonine phosphatases 
ProteomicsActivation loop phosphorylation and cGMP saturation of PKG regulate egress of malaria parasites
The cGMP-dependent protein kinase (PKG) is the sole cGMP sensor in malaria parasites, acting as an essential signalling hub to govern key developmental processes throughout the parasite life cycle. Despite the importance of PKG in the clinically relevant asexual blood stages, many aspects of malaria...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2024-06-24 | PXD049017 | Pride
Phosphorylation Cgmp-dependent protein kinase Malaria Genetics Plasmodium falciparum 
ProteomicsA multipass membrane protein interacts with the cGMP-dependent protein kinase to regulate critical calcium signals in malaria parasites
In malaria parasites, all cGMP-dependent signalling is mediated through a single cGMP-dependent protein kinase (PKG). A major function of PKG is to control calcium signals essential for the parasite to exit red blood cells or for transmission to the mosquito vector. However, how PKG controls these s...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2021-02-10 | PXD020381 | Pride
Transporter Plasmodium falciparum Calcium regulation Plasmodium berghei Phosphoproteomics Cgmp-dependent protein kinase (pkg) 
ProteomicsTPL-2 kinase induces phagosome acidification to promote macrophage killing of bacteria
Tumor Progression Locus 2 (TPL-2) kinase mediates Toll-like Receptor (TLR) activation of ERK1/2 and p38 MAP kinases in myeloid cells to modulate expression of key cytokines in innate immunity. This study identified a novel MAP kinase-independent regulatory function for TPL-2 in phagosome maturation,...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-24 | PXD020247 | Pride
Macrophage Bacteria Tpl-2 V-atpase Staphylococcus aureus Dmxl1 Phagosome 
UnknownGenome-wide studies define new genetic mechanisms of IgA vasculitis.
Not available
S-EPMC11482997 | biostudies-literature
Unknown2013 NS-AUA Abstracts
Not available
S-EPMC3854476 | biostudies-literature
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