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ProteomicsProteomic analysis neutrophils from COVID-19 patients
To go further insight into the involvement of neutrophils in COVID-19 clinical expression, we performed a proteomic analysis of this blood cell type in COVID-19 patients and two non-infected SARS-CoV-2 control groups composed of healthy subjects and ARDS patients hospitalized in intensive care unit ...
ORGANISM(S): Homo sapiens (Human) 
2022-07-27 | PXD033293 | Pride
Tims-tof Neutrophil Covid-19 Labelfree 
ProteomicsPIEZO1-related Hereditary Xerocytosis Red Blood Cell proteomics
Proteome of purified erythrocytes from blood samples from patients diagnosed with a PIEZO1-HX based on familial history, non-spherocytic chronic hemolysis, typical osmotic gradient ektacytometry and molecular testing and from healthy donors were analyzed by a label free quantification approach.
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD031963 | Pride
Erythrocytes   red blood cells   piezo1   xerocytosis   label free   orbitrap velos   human 
ProteomicsQuantitative analysis of the erythrocyte kinome
The erythrocytes, the most numerous cells of the human body (Sender 2016), have the fundamental function of providing oxygen to the other cells throughout the organism. Protein phosphorylations are involved in the regulation of several important mechanisms in erythrocytes, such as cytoskeleton remod...
ORGANISM(S): Homo sapiens (Human) 
2018-09-18 | PXD009396 | Pride
Erythrocytes Red blood cells Kinome Kinases Label free quantification Human primary cells 
ProteomicsAbsolute proteome quantification of highly purified reticulocytes and erythrocytes
Erythrocytes are the most numerous cells of the human body (Sender 2016). Their lifespan in the blood stream is around 120 days. The turnover implies the production of 2 million new reticulocytes each second. Circulating reticulocytes achieve their maturation in 2 to 3 days. During this short time, ...
ORGANISM(S): Homo sapiens (Human) 
2018-09-18 | PXD009258 | Pride
Red blood cells Reticulocytes Erythrocytes Label free quantification Human primary cells 
ProteomicsPhosphoproteomic analysis of leukemic cells after RNA interference-mediated depletion of CDC25A
Molecular and functional networks driving coordination between cell cycle and mRNA translation remain to be explored. Here, we used mass spectrometry-based proteomics to comprehensively investigate the interactome and phosphoproteome of the cell cycle regulator CDC25A. This highlighted several actor...
ORGANISM(S): Homo sapiens (Human) 
2026-07-15 | PXD066447 | Pride
Cell cycle Mrna Cdc25a Rna binding proteins Translation Lc-ms/ms 
ProteomicsNovel CDK-independent function of CDC25 phosphatases in mRNA translation
Investigating CDC25A interacting proteins and identifying new CDC25A substrates.
ORGANISM(S): Homo sapiens (Human) 
2026-07-15 | PXD066262 | Pride
Ls-ms/ms Lfq Cell cycle Mrna Cdc25a Rna binding proteins Translation 
ProteomicsDeep proteomic analysis of murine erythroid differentiation
Erythropoiesis is a tightly controlled process. Although human and murine erythropoiesis are grossly similar, several aspects of these processes present significant differences. We have performed a label free quantification of proteins expressed during murine erythroid differentiation of primary cel...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD009384 | Pride
Erythroid differentiation Erythroblast Label free quantification Mouse Erythropoiesis Murine Erythropoiesis 
ProteomicsmRNA length and 3’UTR structure govern the translation selectivity in RPS14-haploinsufficient erythroblasts
5q- syndrome is a somatic ribosomopathy linked to the monoallelic deletion of the RPS14 gene and characterized by a proeminent erythroid phenotype. The mechanism of anemia involves an impaired differentiation and increased apoptosis of erythroblasts. We have analyzed total cell extracts from UT7 cel...
ORGANISM(S): Homo sapiens (Human) 
2021-04-28 | PXD008650 | Pride
Human Label free Ribosome Ut7 Rps14 Utr Erythropoiesis 
ProteomicsHuman acute myeloid leukemia (AML) cell line LFQ, comparison between doxycycline-inducible control shRNA and Pim2 shRNA
Acute myeloid leukemia (AML) with the FLT3 internal tandem duplication (FLT3-ITD AML) accounts for 20-30% of AML cases. This subtype usually responds poorly to conventional therapies including FLT3 tyrosine kinase inhibitors (TKIs) due to molecular bypass mechanisms. New therapeutic strategies are t...
ORGANISM(S): Homo sapiens (Human) 
2017-09-18 | PXD005880 | Pride
Aml Rna interference Pim2 Lfq 
ProteomicsProteomic analysis of Red blood cells membrane
We analyzed the proteome of ghosts Red Blood Cells using a label free proteomic approach.
ORGANISM(S): Homo sapiens (Human) 
2025-07-23 | PXD054072 | Pride
Red blood cells Membrane proteins Nlc-ms/ms Label free 
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