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ProteomicsFFPE tumor samples reveals the influences of NET-1 siRNA nanoparticles and sonodynamic therapy on tetraspanin protein involved in HCC
Hepatocellular carcinoma (HCC) poses a severe threat to human health. The NET-1 protein has been proved to be strongly associated with HCC proliferation and metastasis in our previous study. Here, we established and validated NET-1 siRNA nanoparticles system to conduct targeted gene therapy of HCC x...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020763 | Pride
Ultrasound Proteomics Mass spectrometry Tetraspanin protein Hepatocellular carcinoma Sonodynamic therapy 
ProteomicsProteomic analysis of HCC-1954 and MCF-7 cell lines highlights crosstalk between αvβ1 integrin, E-cadherin and HER-2
Overexpression of human epidermal growth factor receptor 2 (HER-2) occurs in 20% of all breast cancer subtypes, those that present the worst prognostic outcome through a very invasive and aggressive tumour. HCC-1954 (HER-2+) is a highly invasive, metastatic cell line whereas MCF-7 is mildly aggressi...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD023876 | Pride
Hcc-1954 Membrane proteins Her-2 Breast cancer Mcf-7 Proteome 
ProteomicsProteomic characterization of human hepatocellular carcinoma (HCC) tumor biopsies
We analyzed the proteome of tumor and matched non-tumor biopsies from 51 treatment-naive Hepatocellular carcinoma (HCC) patients by DIA (SWATH). Thereby we aim to find subgroups of patients characterized by specific pathway activation. Furthermore, we aim to find novel factors involved in HCC develo...
ORGANISM(S): Homo sapiens (Human) 
2022-03-14 | PXD025705 | Pride
Human Swath Biopsies Hcc 
ProteomicsDifferential proteomics between AFP-negative HCC and adjacent non-tumor liver tissue
We screened and identified novel proteins in AFP-negative HCC tissue that were differentially expressed related to levels in adjacent non-tumor liver tissue using SWATH-MS proteome technology
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD028854 | Pride
Swath-ms Hcc 
ProteomicsPhospho-proteomic characterization of human hepatocellular carcinoma (HCC) tumor biopsies
We analyzed the phospho-proteome of tumor and matched non-tumor biopsies from 51 treatment-naive Hepatocellular carcinoma (HCC) patients by label-free DDA. Thereby we aim to find subgroups of patients characterized by specific pathway activation. Furthermore, we aim to find novel factors involved in...
ORGANISM(S): Homo sapiens (Human) 
2022-03-14 | PXD025836 | Pride
Human Qexactive hf Phospho-proteomics Hepatocellular carcinoma (hcc) Biopsies 
ProteomicsMYC-driven mouse HCC proteomics
To identify proteomic signatures associated with hepatocellular carcinoma driven by MYC overexpression, proteomics was performed on the LAP-tTA/tetO-MYC mouse conditional liver cancer model. Upon MYC activation, mice form liver cancer. Differential proteomics was performed in "MYC on" (MYC-HCC) mous...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-12 | PXD031478 | Pride
Lc-msms Mouse Cancer Hcc Myc Liver Tumor 
ProteomicsGeneration of the HCC spectral library covering more than 10,000 protein groups
Peptides of HCC cell lines and tumour tissues were fractionated by Hp-RP to eight fractions and repeated analysed three times by the LC-MS/MS detection system consisted of the EASY-nLC 1000 coupled to the Q-Exactive HF mass spectrometer using data dependent acquisition mode.
ORGANISM(S): Homo sapiens (Human) 
2022-11-11 | PXD035028 | Pride
Hcc proteome 
Proteomics(Phospho)-proteomic characterization of longitudinal biopsies from HCC patients treated with sorafenib
Tumor response rates to targeted therapy are generally low. This poses an urgent medical need to identify molecular mechanisms that determine responsiveness, to inform drug development and therapy. Here, we performed a proteomics and phospho-proteomics (p)proteomics analysis on longitudinal tumor bi...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD028593 | Pride
Human Super-silac Sorafenib (phospho)-proteomics ((p)proteomics) Hepatocellular carcinoma (hcc) Biopsies 
ProteomicsIntact N-glycopeptides and proteomics from HCC tissue tumors with low and high AFP concentrations
Hepatocellular carcinoma (HCC) is still one of the malignant tumors with high morbidity and mortality in China and worldwide. Although AFP have been widely used as important biomarkers for HCC diagnosis and evaluation, the AFP level has a huge variation among HCC patient populations. Understanding t...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD016406 | Pride
Proteomics Intact glycopeptide Mass spectrometry Hepatocellular carcinoma 
ProteomicsHCC progression - Quantitative proteome analysis reveals the correlation between endocytosis-associated proteins and hepatocellular carcinoma dedifferentiation
Endocytosis is a cellular function which is likely to take part in HCC development due to its important role in regulating the abundances of vital signaling receptors. In this study, we aimed to investigate the expression of endocytosis-associated proteins in HCCs with various differentiation grades...
ORGANISM(S): Homo sapiens (Human) 
2016-09-27 | PXD003552 | Pride
Label-free proteomics Scamp3 Hepatocellular carcinoma Cltc Endocytosis Liver. 
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