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UnknownCathepsin B as a potential cystatin M/E target in the mouse hair follicle.
Not available
S-EPMC5602906 | biostudies-literature
TranscriptomicsPre-BCR Signaling induce IgK Locus Accessibility by functional redistribution of Enhancer-mediated chromatin Interactions
During B cell development the precursor B cell receptor (pre-BCR) checkpoint is thought to increase immunoglobulin k light chain (Igk) locus accessibility to the V(D)J recombinase. Accordingly, pre-B cells lacking the pre-BCR signaling molecules Btk or Slp65 showed reduced germline Vk transcription....
ORGANISM(S): Mus musculus 
2014-03-21 | E-GEOD-53896 | biostudies-arrayexpress
UnknownInterim Results of a Phase 1-2a Trial of Ad26.COV2.S Covid-19 Vaccine.
Not available
S-EPMC7821985 | biostudies-literature
ProteomicsRNF212B E3 ligase is essential for crossing over maturation and mouse fertility
Meiosis, a reductional cell division, relies on precise initiation, maturation and resolution of crossovers (COs)-connections between homologs chromosomes-to ensure their accurate segregation during metaphase I. This process is finely regulated in eukaryotes by the interplay of RING-E3 ligases such ...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-31 | PXD047019 | Pride
Crossing-over Ubiquitylation Meiotic recombination Chiasma Fertility Sumoylation Rnf212b Ring e3 ligases Spermatogenesis 
ProteomicsDNAJC9 integrates heat shock molecular chaperones into the histone chaperone network
From biosynthesis to assembly into nucleosomes, histones are handed through a cascade of histone chaperones, which shield histones from non-specific interactions. Whether mechanisms exist to safeguard the histone fold during histone chaperone handover events or to release trapped intermediates is un...
ORGANISM(S): Homo sapiens (Human) 
2021-04-14 | PXD020268 | Pride
Hsp70 Histone chaperone Heat shock Hsp40 Dnajc9 Chaperone 
ProteomicsDNAJC9 prevents CENP-A mislocalization and chromosomal instability by maintaining the fidelity of histone supply chains
The centromeric histone H3 variant CENP-A is overexpressed in many cancers. The mislocalization of CENP-A to noncentromeric regions contributes to chromosomal instability (CIN), a hallmark of cancer. However, pathways that promote or prevent CENP-A mislocalization remain poorly defined. Here, we per...
ORGANISM(S): Homo sapiens (Human) 
2024-04-11 | PXD043961 | Pride
Chromosomal instability Dnajc9 Epigenetics Mitosis Histone chaperone Centromere Chaf1b Caf-1 complex Cenp-a 
UnknownPharmacologically directed strategies in academic anticancer drug discovery based on the European NCI compounds initiative.
Not available
S-EPMC5520516 | biostudies-literature
ProteomicsCatalytic and non-catalytic functions of DNA polymerase kappa in translesion DNA synthesis
Translesion DNA synthesis (TLS) is a cellular process that enables the bypass of DNA lesions encountered during DNA replication and is emerging as a primary target of chemotherapy. Among vertebrate DNA polymerases, polymerase kappa (PolK) has the distinctive ability to bypass minor groove DNA adduct...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2024-08-27 | PXD044258 | Pride
Xenopus Tls Polz Polk Rev1 Polymerase kappa Ubiquitin Translesion dna synthesis Pcna Dna replication 
UnknownAlcohol Consumption, Drinking Patterns, and Cognitive Performance in Young Adults: A Cross-Sectional and Longitudinal Analysis.
Not available
S-EPMC7019481 | biostudies-literature
ProteomicsMaxQuant.Live enables enhanced selectivity and identification of peptides modified by endogenous SUMO and ubiquitin
Small ubiquitin-like modifiers (SUMOs) and ubiquitin are frequent post-translational modifications of proteins that play pivotal roles in all cellular processes. We previously reported mass spectrometry-based proteomics methods that enable profiling of lysines modified by endogenous SUMO or ubiquiti...
ORGANISM(S): Homo sapiens (Human) 
2021-02-05 | PXD022367 | Pride
Peptide mass filtering Sumo Mql Ubiquitin Maxquant.live Precursor untargeting 
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