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ProteomicsLC-MSMS of the MHC-I immunopeptidome of human iPSCs
The development of cancer immunotherapeutics is limited by the discovery of actionable tumor-specific antigens (TSAs), which need to be presented at high levels on cancer cells, but not presented by normal tissues or presented at levels below the threshold for T-cell recognition to prevent autoimmun...
ORGANISM(S): Homo sapiens (Human) 
2022-08-22 | PXD026702 | Pride
Lc-msms Induced pluripotent stem cells Immunopeptidome Mhc class i 
ProteomicsDevelopment of Cellular Energy Metabolism During Differentiation of Human iPSCs Into Cortical Neurons
We performed label-free quantitative proteomic profiling to characterize metabolic remodeling during early differentiation of human iPSCs into excitatory cortical neurons induced by NGN2 overexpression. Proteomic analysis was conducted at three time-points (iPSCs, day 7, and day 14 post-induction), ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD064787 | Pride
Human Lc-msms Ipscs Cell culture Neurons 
ProteomicshiPSCs with different colony morphology
Here we characterize the the proteome of iPSCs classified into three morphology groups.
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD013481 | Pride
Human Ipscs lc-msms 
ProteomicsMotor neuron synaptosomes LC-MSMS
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease causing progressive dysfunction and degeneration of upper and lower motor neurons. An increasing body of evidence has identified synaptic alterations in patients and experimental models of ALS. Importantly, these have been asso...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD063154 | Pride
Human Lc-msms Ipscs Motor neurons 
ProteomicsFUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy
Unraveling the mechanistic link connecting the multiple RNA-binding proteins (RBPs) associated with amyotrophic lateral sclerosis (ALS) is critical for identifying novel therapeutics. Mutations in the RBP FUS cause the third most common genetic form of ALS. Here, we show that motor neurons (MNs) of ...
ORGANISM(S): Homo sapiens (Human) 
2019-03-26 | PXD010966 | Pride
Lc-msms Autophagy Proteomics Induced pluripotent stem cells Als Label free quantification Amyotrophic lateral sclerosis Fus Rna-binding proteins Proteostasis 
ProteomicsIn vitro reconstitution of epigenetic reprogramming in the human germ line
M1-BTAG iPSCs or TET1-KO iPSCs were analyzed by 8% SDS-PAGE, followed by trypsin digestion and LC/MS/MS with an Orbitrap Fusion Lumos linked with an Ultimate 3000 pump and HTC-PAL autosampler. Acquired data files were processed using FragPipe v20.0 (MSFragger v3.8, Philosopher v5.0.0, IonQuant v1.9....
ORGANISM(S): Homo Sapiens (human) 
2024-04-25 | PXD048118 | JPOST Repository
ProteomicsExploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis
Chlamydia trachomatis remains a leading cause of bacterial sexually transmitted infections and preventable blindness worldwide. There are, however, limited in vitro models to study the role of host genetics in the response of macrophages to this obligate human pathogen. Here, we describe an approach...
ORGANISM(S): Chlamydia trachomatis Homo sapiens (Human) 
2018-02-14 | PXD005858 | Pride
Tmt Chlamydia Ips cells Lc-msms 
ProteomicsThe global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation The global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation
Translational regulation is of paramount importance for proteome remodeling during stem cell differentiation both at the global and transcript-specific levels. In this study, we characterized translational remodeling during hepatogenic differentiation of induced pluripotent stem cells (iPSCs) by pol...
ORGANISM(S): Homo sapiens (Human) 
2022-12-26 | PXD038204 | Pride
Translational regulation Top mrna Hepatocyte differentiation Stem cells 
ProteomicsComparative proteomics between 2D and 3D (neurospheres) cultured NSCs
Neurospheres are a relevant 3D model with many applications, but it lacks sufficient omics studies. Here, we performed a comparative proteomics experiment to investigate what distinguishes a 2D from a 3D culture of Neural Stem Cells (NSCs). In both cases, NSCs were iPSC-derived.
ORGANISM(S): Homo sapiens (Human) 
2026-01-20 | PXD063185 | Pride
Tmt Neurospheres Lc-msms 
ProteomicsMice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties
Astrotactin 2 (ASTN2) is a transmembrane neuronal protein highly expressed in the cerebellum that functions in receptor trafficking and modulates cerebellar Purkinje cell (PC) synaptic activity. Individuals with ASTN2 mutations exhibit neurodevelopmental disorders, including autism spectrum disorder...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-30 | PXD052868 | Pride
Astn2 Purkinje cell Neurodevelopmental disorder Cerebellum Autism spectrum disorder 
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