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ProteomicsMolecular characterization of the eukaryotic Uba4/Urm1 system
Ubiquitin-like protein activator 4 (Uba4) is required for the thiolation of uridine bases in eukaryotic transfer RNA. Uba4 catalyzes the sequential adenylation and thiocarboxylation of the C-terminus of Ubiquitin related modifier 1 (Urm1), acting as a hybrid between an E1-like activating enzyme and ...
ORGANISM(S): Chaetomium thermophilum 
2020-07-14 | PXD015802 | Pride
Uba4 Urmylation Urm1 
ProteomicsIs transthyretin a regulator of Ubc9 SUMOylation?
Ageing and mutations of transthyretin (TTR), the thyroid hormones and retinol transporting protein lead to amyloidosis by destabilizing the structure of TTR. Because protein structure is regulated through posttranslational modifications, we investigated the Small Ubiquitin-like Modifier (SUMO)ylatio...
ORGANISM(S): Homo sapiens (Human) 
2016-08-15 | PXD004515 | Pride
Post-translational modifications Sumoylation Transthyretin Ubc9 Ufds 
ProteomicsImipramine affects the expression of proteins involved in oxidative stress and immunity in rat primary glial cell culture
Glial cells (microglia and astrocytes) have recently became appreciated as an important target for antidepressant drugs. Here we report on the results of comprehensive proteomic analysis of the alteration in protein profile of rat primary mixed glial culture exposed to imipramine. Two-dimensional di...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-05-17 | PXD007977 | Pride
Imipramine  mixed glial cell culture  microglia  proteome  2d-dige 
ProteomicsProteome analysis of PC12 cells reveals alterations in translation regulation and actin signalling induced by clozapine
Although antipsychotics are routinely used in the treatment of schizophrenia for last decades, their precise mechanism of action is still unclear. In this study we investigated changes in PC12 cells’ proteome under the influence of clozapine, risperidone and haloperidol to identify protein pathways ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-08 | PXD014422 | Pride
Proteome Clozapine Translation Actin signalling Mtor 
ProteomicsSNAIL is a key regulator of rhabdomyosarcoma progression and myogenic differentiation
Rhabdomyosarcoma (RMS) is a frequent non-epithelial tumor of soft tissue that originates from a myogenic differentiation defect. Expression of SNAIL transcription factor is elevated in the alveolar subtype of RMS, characterized by a low myogenic differentiation status and high aggressiveness. SNAIL ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-14 | PXD006711 | Pride
Snail (snai1) Myod Myomirs Myogenic differentiation Rhabdomyosarcoma (rms) Myf5 Metastasis 
ProteomicsIntegrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism
Obesity is considered a serious chronic disease, which is associated with increased risk of developing cardiovascular diseases, non-alcoholic fatty liver disease and type 2 diabetes. Monocyte chemoattractant protein-1-induced protein-1 (MCPIP1), also called Regnase-1, is an RNase that decreases stab...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-07 | PXD010148 | Pride
Adipogenesis Adipocytes Mcpip1 Lc-ms/ms 
ProteomicsAn insight into the proteome of uveal melanoma-derived ectosomes reveals the presence of potentially useful biomarkers
Cancer cells are known to release extracellular vesicles that often promote disease development and progression. The present study investigated protein content and glycosylation pattern of ectosomes released in vitro by human primary uveal melanoma Mel202 cell line. Ectosomes released by Mel202 cell...
ORGANISM(S): Homo sapiens (Human) 
2019-08-08 | PXD012003 | Pride
Glycosylation Uveal melanoma Proteomics Extracellular vesicles Lectins Ectosomes 
ProteomicsRepurposing BCL2 inhibitors: Venetoclax protects against acinar cell necrosis in acute pancreatitis by promoting apoptosis
Acute pancreatitis (AP), a severe inflammatory disorder of the pancreas, lacks effective pharmacological treatment. The disease is primarily driven by necrosis of pancreatic acinar cells (PACs), which intensifies inflammation and organ injury. This study explores the potential of BCL2 inhibitors, sp...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-04 | PXD064881 | Pride
Pancreas Bcl2 inhibitors Venetoclax Pancreatitis Abt-199 Calcium signaling Fibrosis Abt-263 Necrosis Navitoclax Apoptosis 
ProteomicsCryo-EM structures of the human Elongator complex at work
The deposited data concern the mapping of acetylation sites on wild-type and the K280A, Y363A mutants of Elp3 by LC-MS/MS. Abstract of the manuscript: tRNA modifications affect ribosomal elongation speed and co-translational folding dynamics. The Elongator complex is responsible for introducing 5-ca...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092998 | MassIVE
ProteomicsHyperosmolarity adversely impacts heterologous secretory protein synthesis by Yarrowia lipolytica
In this research we were interested in answering a question whether subjecting Y. lipolytica strain overproducing recombinant secretory protein (rs-Prot) to a specific, pre-optimized stress factor may enhance synthesis of the target macromolecule. Increased osmolarity (3 Osm/kg) was the primary stre...
ORGANISM(S): Yarrowia Lipolytica (ncbitaxon:4952) 
2021-10-13 | MSV000088228 | MassIVE
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