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ProteomicsHeart Mitochondrial Proteome - The Failing Heart Relies on Ketone Bodies as a Fuel
Isolation of Heart Mitochondria of defined stages of pressure overload-induced heart failure in mice
ORGANISM(S): Mus musculus (Mouse) 
2016-05-09 | PXD001820 | Pride
Mouse heart mitochondria 
ProteomicsPhosphoproteomics of the developing heart identifies PERM1 - an outer mitochondrial membrane protein
Heart development relies on PTMs that control cardiomyocyte proliferation, differentiation and cardiac morphogenesis. We generated a map of phosphorylation sites during the early stages of cardiac postnatal development in mice; we quantified over 10,000 phosphorylation sites and 5000 proteins that w...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-07-21 | MSV000085796 | MassIVE
ProteomicsHELA cells Sphingolipid pulldown (Cers6 and Cers5)
Ectopic lipid deposition and altered mitochondrial dynamics contribute to the development of obesity and insulin resistance. However, the mechanistic link between both processes remains unclear. Here we demonstrate that abrogation of ceramide synthase (CerS)6, which generates C16:0-sphingolipids, bu...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD007158 | Pride
Hela Cer6 Cers5 Sphingolipid Click chemistry 
ProteomicsOviductal fluid LC-MS/MS - The Wilms tumor protein Wt1 contributes to female fertility by regulating oviductal proteostasis
After fertilization the developing mammalian embryo migrates through the oviduct before it implants in the uterus. In order to prevent tubal pregnancy or failed implantation, development and migration of the embryo has to be tightly coordinated1. The precise molecular basis for the regulation of thi...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-04 | PXD003283 | Pride
Oviductal fluid Wt1 Lc-ms/ms Prss29 
ProteomicsHELA cells PARL Immunoprecipitation
The SPFH (Stomatin, Prohibitin, Flotillin, HflC/K) superfamily is composed of scaffold proteins that form ring-like structures and locally specify the protein-lipid composition in a variety of cellular membranes. Stomatin-like protein 2 (SLP2) is a member of this superfamily that localizes to the...
ORGANISM(S): Homo sapiens (Human) 
2016-10-18 | PXD004914 | Pride
Hela Parl Flag-ip 
ProteomicsMouse Liver LC-MSMS - Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation
Mice were starved overnight and divided into three groups: a) refed for 30 min b) caged food (not able to reach, but to smell and see food) c) further fasted. The aim of the study was to determine phosphorylation events in the liver in response to visual exposure of food. See more details in the man...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-31 | PXD005681 | Pride
Mouse Silac Liver Phosphoproteome 
ProteomicsMouse heart mitochondria LC-MS/MS
Heart mitochondria proteome to identify changes induced by knock-out of Clpp.
ORGANISM(S): Mus musculus (Mouse) 
2017-01-16 | PXD002935 | Pride
Heart mouse mitochondria clpp clpx 
ProteomicsSpatial proteomics of the diaphragm
The thoracic diaphragm is a vital organ for respiration and morphological studies of the diaphragm have provided a detailed view of its architecture consisting of parallel muscle fibers, a central ring of neuromuscular junction (NMJ) units and a muscle-tendon transition area. Although immunohistoche...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-22 | PXD054352 | Pride
Nmj Diaphragm Spatial proteomics Mtj 
OtherAdvanced identification of proteins in uncharacterized proteomes by pulsed in vivo SILAC
TRANCHE KEY: EfXsK8WKQKnCiGubVrXxCmmygO9Wbb8TYBBFZgdSBwla6M3AjwhqeHpWgNp8DijuGCbKH49+jBc625dSmgLPaNuv0JgAAAAAAAAB0w== Newt Tail Raw Data 12. A pulsed SILAC-based mass spectrometry method was used , which is based on the detection of paired peptides after 13C6-lysine incorporation into proteins in vi...
ORGANISM(S): Stropicalis Ncbi, Xlaevis Ncbi, Caudata 
GPM32300000779 | GPMDB
ProteomicsMurine kidney glomeruli phosphorylation
Isolated murine kidney glomeruli were lysed in buffer containing 8M urea, and proteins were reduced and alkylated. Proteins were digested with trypsin. After reverse-phase chomatrography, peptides were fractionated using strong cation exchange chromatography. Phosphopeptides were enriched using IMAC...
ORGANISM(S): Mus musculus (Mouse) 
2016-05-09 | PXD000266 | Pride
Mouse Podocytes Kidney Glomerular epithelial cell Phosphoproteomics 
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