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ProteomicsCoactosin phosphorylation controls Entamoeba histolytica 1 cell membrane protusions and cell motility
Invasion of the colon wall by Entamoeba histolytica during amoebic dysentery entails migration of trophozoites through tissue layers that are rich in extracellular matrix (ECM). Transcriptional silencing of the E. histolytica matrix surface metalloprotease EhMSP-1 produces hyper-adherent, less motil...
ORGANISM(S): Entamoeba histolytica HM-1:IMSS-B Entamoeba histolytica HM-1:IMSS-A Entamoeba histolytica HM-1:IMSS Entamoeba histolytica 
2020-07-15 | PXD018276 | Pride
Lc-msms Phosphopeptides Entamoeba histolytica 
ProteomicsLysyl Oxidases are Necessary for Myometrial Contractility and On-Time Parturition in Mice
The extracellular matrix (ECM) plays a pivotal role in the maintenance of tissue mechanical homeostasis. Collagens and elastic fibers are the most predominant fibrous ECM proteins providing tissue mechanical function through covalent cross-linking, which is mediated by the lysyl oxidase family of en...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-18 | PXD055537 | Pride
Lysyl oxidase Pregnancy Extracellular matrix Myometrium Parturition 
ProteomicsQuantification profiles of enzyme activity, secretion and psychosine levels of Krabbe disease galactosylceramidase missense variants
Krabbe disease (KD) is an autosomal recessive lysosomal storage disorder caused by loss-offunction mutations in the GALC gene, which encodes for the enzyme galactosylceramidase (GALC). GALC is crucial for myelin metabolism. Functional deficiency of GALC leads to toxic accumulation of psychosine, dys...
ORGANISM(S): Homo sapiens (Human) 
2025-05-19 | PXD057472 | Pride
Secretion Missense mutation variant Galactosylceramidase Lysosomal storage disorder Lysosome Galc Psychosine Crispr-cas9 knockout cell Protein trafficking Krabbe disease Expression study Genotype-phenotype correlation Galactosylsphingosine Globoid cell leukodystrophy 
ProteomicsAblation or Inhibition of Protein Disulfide Isomerase A3 (PDIA3) in Aberrant Club Cells Attenuates Osteopontin (SPP1) Production and Pulmonary Fibrosis
Rationale: The role of club cells in the pathology of Idiopathic Pulmonary Fibrosis IPF is not well understood. PDIA3, an endoplasmic reticulum (ER) based redox chaperone catalyzes the cysteine disulfide bonds (-S-S-) in various fibrosis-related proteins; however, mechanisms of action of PDIA3 in pu...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-11 | PXD021715 | Pride
Ipf Pdia3 Osteopontin Upr Pulmonary fibrosis Loc14 Spectral counting Ccsp Lc-ms/ms 
ProteomicsLF2 phosphorylation of the CDKL5 activation loop controls CDKL5’s activity
Cdkl5 Deficiency Disorder (CDD) is caused by variants in the protein kinase CDKL5, leading to symptoms such as seizures, developmental delay, and severe intellectual disability. The Chlamydomonas homologue of human CDKL5 is the flagellar protein LF5, whose absence results in a long flagella phenotyp...
ORGANISM(S): Chlamydomonas reinhardtii 
2025-11-18 | PXD066877 | Pride
Chlamydomonas Cilia Cdkl5 deficiency disorder Ciliopathy Intraflagellar transport Kinase Flagella 
ProteomicsStructural and functional fine mapping of cysteines in mammalian glutaredoxin reveal a hierarchy of susceptibility to oxidative inactivation
Protein-S-glutathionylation (PSSG) is a post-translational modification involving the conjugation of glutathione to reactive protein thiols, which can modulate the activity and structure of key cellular proteins. Glutaredoxins (GLRX) are oxidoreductases that regulate this process by performing the r...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD026486 | Pride
Molecular dynamics Glutathione Multiscale modeling Redox S-glutathionylation Quantum mechanics 
ProteomicsTargeting mitochondrial reactive oxygen species alleviates allergic airway disease in a mouse model of obese allergic asthma
Obesity is associated with severe, difficult to control asthma, and increased airway oxidative stress. Mitochondrial reactive oxygen species (mROS) are an important source of oxidative stress leading us to hypothesize that targeting mROS in obese allergic asthma might be an effective treatment strat...
ORGANISM(S): Bos taurus (Bovine) Mus musculus (Mouse) 
2023-06-02 | PXD029715 | Pride
Obesity Mitochondrial reactive oxygen species (mros) Allergic asthma Airway oxidome Unfolded protein response (upr). Mitoquinone Tissue eosinophilia 
UnknownDeath following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic.
Not available
S-EPMC10364875 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
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