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ProteomicsNew Insights into the impact of Human Papillomavirus on Oral Cancer in Young Patients: Proteomic Approach Reveals a Novel Role for S100A8
Human Papillomavirus (HPV) infection has been recently linked to a subset of cancers affecting the oral cavity. However, the molecular mechanisms underlying HPV-driven oral squamous cell carcinoma (OSCC) onset and/ progression are poorly understood. Methods: We perform a MS-based proteomic profiling...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD041856 | Pride
New insights into the impact of human papillomavirus on oral cancer in young patients: proteomic approach reveals a novel role for s100a8 
ProteomicsCryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals new features of arthritogenic alphaviruses
Characterize the glycosylation sites in E1 and E2, which are transmembrane proteins that are organized in heterodimers.
ORGANISM(S): Homo sapiens (Human) Mayaro virus (strain Brazil) 
2021-05-28 | PXD024432 | Pride
Cryo-em structure  alphaviruses  mass spectrometry  glycosylation 
ProteomicsDifferent biological effects of exposure to far-UVC (222 nm) and near-UVC (254 nm) irradiation
Ultraviolet C (UVC) light has long been used as a sterilizing agent, primarily through devices that emit at 254 nm. Depending on the dose and duration of exposure, UV 254 nm can cause erythema and photokeratitis and potentially cause skin cancer since it directly modifies nitrogenated nucleic acid b...
ORGANISM(S): Homo sapiens (Human) 
2026-02-05 | PXD037726 | Pride
Uvc Irradiation Skin Germicidal lamp Hairless mice 
ProteomicsIdentification of flagellin proteins from the citrus canker pathogens Xanthomonas citri (strain 306) and Xanthomonas aurantifolii pathotype C (strain ICMP 8435)
In this project, we have extracted the flagellum of the citrus canker pathogens Xanthomonas citri and Xanthomonas aurantifolii pathotype C and the proteins associated with these preparations were resolved by SDS-PAGE and identified by mass spectrometry. The major 50 kDa band, observed in both sample...
ORGANISM(S): Xanthomonas citri pv. fuscans 
2023-05-10 | PXD037760 | Pride
Flic Xanthomonas citri (strain 306) and xanthomonas aurantifolii pathotype c (strain icmp 8435) Flagellin c 
ProteomicsMapping the interactome of OSCC prognostic-associated proteins NDRG1 and PGK1 through proximity labeling using TurboID
Oral squamous cell carcinoma (OSCC) is a prevalent type of head and neck cancer, accounting for more than 90% of all oral malignancies worldwide. The identification of diagnostic and prognostic markers for OSCC is crucial for improving patient outcomes, as early detection and treatment are critical ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD048046 | Pride
Ndrg1 Oral cancer Pgk1 Turboid Interactome Proximity labeling Prognostic 
ProteomicsGlutaminase C N-terminus phosphorylation decreases its enzymatic activity
The gene GLS generates the phosphate activated glutaminase C (GAC) isoform by alternative splicing. GAC, compared to the other isoform, kidney-type glutaminase (KGA), has been characterized as more active and particularly important for cancer cell growth. Very little is known about post-translationa...
ORGANISM(S): Homo sapiens (Human) 
2018-08-13 | PXD008338 | Pride
Metabolism Mapk1 Breast cancer Glutaminase Phosphorylation 
ProteomicsReductionist approach using primary and metastatic cell-derived extracellular vesicles prospect proteins associated with oral cancer prognosis
Oral squamous cell carcinoma (OSCC) shows high mortality rates that are largely associated with the presence of lymph node metastasis. However, the molecular mechanisms that drive OSCC metastasis are unknown. Here, we used a reductionist approach mapping the proteomic, miRNA, metabolomic and lipidom...
ORGANISM(S): Homo sapiens (Human) 
2021-07-19 | PXD019216 | Pride
Metabolomics Mirna Multi-omics approach Lipidomics Lymph node metastasis Extracellular vesicles Oral cancer squamous cell carcinoma Proteomics Prognosis 
ProteomicsMetformin impairs cisplatin effects in cell size and proliferation of A549 lung cancer cells, modulating the mTOR and other metabolic pathways.
Lung cancer is the leading cause of cancer death worldwide and reports innate and acquired therapeutic resistance to cisplatin. Metformin (MET), an antidiabetic agent with potential antitumor activity, overcomes cisplatin resistance in some cancers through AMPK-dependent and independent mechanisms. ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD017645 | Pride
Silac Proteomic Nsclc  cisplatin resistance  metformin  mtor pathway 
ProteomicsComprehensive glycoprofiling of oral tumours associates N-glycosylation with lymph node metastasis and patient survival
While altered protein glycosylation is regarded a trait of oral squamous cell carcinoma (OSCC), its heterogeneous glycoproteome and dynamics with disease progression remain unmapped. Employing an integrated multi-omics approach comprising unbiased and quantitative glycomics and glycoproteomics on re...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD037134 | Pride
Glycomics Lymph node metastasis Glycoproteomics Glycosylation Glycoproteome Oral cancer 
ProteomicsFFPE oral cancer - Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer
Laser Microdissection (LMD) associated to LC-MS/MS were used to analyze the proteome of neoplastic islands and stroma tumor of Formalin-Fixed and Paraffin Embedded (FFPE) OSCC tissues to identify proteins of prognostic value. Label-free protein quantification and statistical analysis revealed neopla...
ORGANISM(S): Homo sapiens (Human) 
2018-09-10 | PXD007232 | Pride
Lc-ms/ms Ffpe Oscc 
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