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ProteomicsA covalent fragment screen identifies ferroptosis induced by GPX4 inhibition as a vulnerability of senescent cells
Senescent cells drive ageing and age-related pathologies, including cancer. Consequently, senolytics, drugs that selectively kill senescent cells, have a broad therapeutic appeal. Here, we report a senolytic screen of a library of 10,480 covalent fragments. Amongst 44 identified hits, we found a ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD068572 | Pride
Gpx4 Rsl3 Cancer Senescence Covalent fragments Ferroptosis Senolytics One-two punch Covalent inhibitors Chloroacetamides 
ProteomicsGLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function
Glucagon-like peptide-1 receptor (GLP-1R) agonists (GLP-1RAs) ameliorate mitochondrial health by increasing mitochondrial turnover in metabolically relevant tissues. Mitochondrial adaptation to metabolic stress is crucial to maintain pancreatic -cell function and prevent type 2 diabetes (T2D) progre...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-09-30 | PXD056782 | Pride
Membrane contact sites Pancreatic beta cells Mitochondrial remodelling Akaps Er-mitochondrial contacts Incretins Sphkap Compartmentalised pka signalling Glp-1r Vap-b 
MetabolomicsChemotherapy Modulation by a Cancer-Associated Microbiota Metabolite (Targeted metabolomics - 2methylisocitrate)

Understanding how the microbiota produces regulatory metabolites is of significance for cancer and cancer therapy. Using a host-microbe-drug-nutrient 4-way screening approach, we evaluated the role of nutrition at the molecular level in the context of 5-fluorouracil toxicity. Notably, our screens...

2025-09-16 | MTBLS9994 | MetaboLights
MetabolomicsChemotherapy Modulation by a Cancer-Associated Microbiota Metabolite (Targeted metabolomics - fluoronucleotides)

Understanding how the microbiota produces regulatory metabolites is of significance for cancer and cancer therapy. Using a host-microbe-drug-nutrient 4-way screening approach, we evaluated the role of nutrition at the molecular level in the context of 5-fluorouracil toxicity. Notably, our screens...

2025-09-16 | MTBLS9991 | MetaboLights
ProteomicsA bacterial histone binds DNA in an unorthodox fashion
Histones are the primary building blocks of chromatin in eukaryotes and many archaea. Bacteria are thought to rely on an orthogonal set of proteins to organize their chromosomes. Several bacterial genomes do, however, encode proteins with putative histone fold domains. Whether these proteins adopt a...
ORGANISM(S): Escherichia coli BL21(DE3) Archaea Bdellovibrio bacteriovorus Leptospira interrogans serovar Manilae 
2023-08-21 | PXD039405 | Pride
Histones Bacteria Nucleoid Chromatin 
ProteomicsIndisulam targets RNA splicing and metabolism to serve as a novel therapeutic strategy for high-risk neuroblastoma
Neuroblastoma is the most common solid tumour in childhood and prognosis remains poor for high-risk cases despite the use of multimodal treatment. Analysis of public drug sensitivity data showed neuroblastoma lines to be particularlysensitive to indisulam, a molecular glue that selectively targets t...
ORGANISM(S): Homo sapiens (Human) 
2022-01-13 | PXD022164 | Pride
Human Lc-msms Cancer cells Drug treatment 
ProteomicsTRF1 averts chromatin remodelling, recombination and replication dependent-Break Induced Replication at mouse telomeres
Telomeric repeat sequences are prone to induce replication stress and one of the core telomere binding proteins, TRF1, is thought to counteract these problems. The molecular mechanisms coming into play upon TRF1 loss were not clearly defined though. This study combines an inducible TRF1 loss with te...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-22 | PXD017022 | Pride
Embryonic fibroblasts Lc-msms Teleomere Mus musculus Shelterin complex 
ProteomicsMechanisms of MCM2-7 helicase activation and initial DNA melting at near base-pair resolution
During eukaryotic DNA replication initiation, inactive MCM2-7 double-hexamers assembled at replication origins must be converted into two active CMG helicases, yet how this transition is coupled to origin DNA unwinding in vivo remains unclear. Here, we identify a DNA-bound intermediate with an exten...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-06-26 | PXD080178 | Pride
Ssdna Helicase Unwinding Origins Dna replication Yeast Chip-exo Mcm2-7 Rpa S-phase 
ProteomicsLipid metabolism drives osimertinib resistance in non-small cell lung cancer
Non-small-cell lung cancer (NSCLC) accounts for more than 80 % of lung cancer cases. Epidermal growth factor receptor mutations (EGFRm) occur in 15 % and 40 % of NSCLC in Western and Asian populations, respectively. Current treatment for advanced NSCLC targets EGFRm with tyrosine kinase inhibitors (...
ORGANISM(S): Homo sapiens (Human) 
2026-03-03 | PXD071008 | Pride
Nonsmall-cell lung cancer  lipidomics  glycosphingolipid  ceramide  sphingolipid Drug resistance  multi-omics  glucosylceramidase 
ProteomicsHuman SKI component SKIV2L regulates telomeric DNA-RNA hybrids and prevents telomere fragility
Super killer (SKI) complex is a well-known cytoplasmic 3′ to 5′ mRNA decay complex that functions with the exosome to degrade excessive and aberrant mRNAs. Recently, SKIV2L, the 3′ to 5′ RNA helicase of the human SKI (hSKI) complex has been implicated with the extraction of mRNA at stalled ribosomes...
ORGANISM(S): Homo sapiens (Human) 
2024-10-03 | PXD046955 | Pride
Skiv2l Genome instability Dna-rna hybrids Dna damage Telomere 
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