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ProteomicsData Independent Acquisition (DIA) based quantification workflow for proteome analysis of GASH/Sal and Control hamster
The GASH/Sal hamster (Genetic audiogenic seizure, Salamanca) is a model of audiogenic seizures with the epileptogenic focus localized in the inferior colliculus (IC). The sound-induced seizures exhibit a short latency (7-9 seconds), which implies innate protein disturbances in the IC as a basis for ...
ORGANISM(S): Mesocricetus auratus (Golden hamster) 
2023-05-10 | PXD039755 | Pride
Maxquant Msstats Dia Dda Mprophet 
ProteomicsDIA Quantification Proteomics of rat tissues including bph and sham rats
In this project, Q-Exactive HF(Thermo Fisher Scientific,San Jose,CA) was used to acquire mass spectrometry (MS) data for 7 samples in Data Independent Acquisition (DIA) mode. Quantification of peptides and proteins was performed using Spectronaut™ and MSstats software packages
ORGANISM(S): Rattus norvegicus (Rat) 
2025-12-01 | PXD032395 | Pride
Lc-msms Prostate Rats 
ProteomicsA Combined Shotgun and Targeted Mass Spectrometry Strategy for Breast Cancer Biomarker Discovery
Metastasizing breast cancer is an incurable disease. Thus, it is important to find proteins responsible for tumor dissemination, which may be used as biomarkers or treatment targets. In this study, we established the combination of a non-targeted LC-MS/MS discovery and a targeted LC-SRM verification...
ORGANISM(S): Homo sapiens (Human) 
2015-06-16 | PXD001685 | Pride
Breast cancer Shotgun Mrm Distant recurrence Srm 
ProteomicsQuantitative analysis of skin proteomics in Chinese young and old populations by mass spectrometry
Aging is a normal physiological phenomenon of organisms. Skin aging is a specific manifestation of aging of local human organs. In this study, we used mass spectrometry to perform non-invasive analysis of the skin of 20 healthy young and elderly people in China. Quantitative proteomic analysis ident...
ORGANISM(S): Homo sapiens (Human) 
2020-08-05 | PXD018430 | Pride
Epidermal protein aging  proteome  mass spectrometer 
ProteomicsOLFM4 expression in breast tumor samples
Here we describe the first study which used SWATH MS as a tool for robust identification and quantification of breast tissus proteins. By employing a spectral library containing 3200 proteins, we show that this strategy allows the quantification of OLFM4 in each sample together with a deep proteomic...
ORGANISM(S): Homo sapiens (Human) 
2019-07-25 | PXD014194 | Pride
Breat cancer Swath-ms Olfm4 
ProteomicsAxonal and somatodendritic proteomes of dopamine neurons in the mouse brain
Dopamine (DA) neurons modulate neural circuits and behaviors via dopamine release from expansive, long range axonal projections. The elaborate cytoarchitecture of DA neurons is embedded within complex brain tissues, making it difficult to access the DA neuronal proteome using conventional methods. H...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-01 | PXD026229 | Pride
Proteomics Apex2 Dopamine neurons Axon 
ProteomicsDirected Differentiation of Human iPSCs into Mesenchymal Lineages by Optogenetic Control of TGF-β Signaling
For chondrogenic studies of optogenetically activated TGF-β signaling, optogenetic human iPSC-derived MSCs were encapsulated in hydrogels (20 million cells/mL of 2% agarose hydrogel). Groups received either no soluble TGF-β or optogenetic stimulation, or soluble TGF-β3 alone, or optogenetic stimulat...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD040232 | Pride
Human Ipsc Chondrogenesis Hydrogel Agarose 
ProteomicsLongitudinal proteomic profiling discovered early prognostic and surrogate markers in COVID-19
In managing patients with coronavirus disease 2019 (COVID-19), early identification of those at high risk and real-time monitoring of disease progression to severe COVID-19 is a major challenge. We aimed to identify early prognostic protein markers and to discover surrogate protein markers that effe...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD023686 | Pride
Covid19 Dia Human Serum 
ProteomicsLongitudinal multi-omic changes in the transcriptome and proteome of peripheral blood cells after a 4 Gy total body radiation dose to Rhesus macaques.
Background: Non-human primates, such as Rhesus macaques, are a powerful model for studies of the cellular and physiological effects of radiation, development of radiation biodosimetry, and for understanding the impact of radiation on human health. Here, we study the effects of 4 Gy total body irradi...
ORGANISM(S): Macaca mulatta (Rhesus macaque) 
2023-05-10 | PXD037807 | Pride
Radiation Biomarkers 
ProteomicsProducts differentially secreted from perigonadal adipose tissue of db/db mice.
A control group of male C57BL/6J mice were fed a 60% fat diet (Research Diets D12492i) for 8 weeks, resulting in “ad libitum obesity” (ALO). Leptin receptor-deficient B6.BKS(D)-Leprdb/J (“db/db”) male mice were fed a low-fat chow diet (PicoLab Rodent Diet 20; Purina Mills Inc). Once the average body...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-23 | PXD051294 | Pride
Adipose tissue Mouse Db/db 
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