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TranscriptomicsResponse of Pseudomonas aeruginosa PAO1 to low shear modeled microgravity
Anticipating the risk for infectious disease during space exploration and habitation is a critical factor to ensure safety, health and performance of the crewmembers. As a ubiquitous environmental organism that is occasionally part of the human flora, Pseudomonas aeruginosa could pose a health hazar...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2010-07-29 | E-GEOD-16970 | biostudies-arrayexpress
ProteomicsType 2 diabetes risk gene Dusp8 is a gatekeeper for hypothalamic Jnk signaling and insulin sensitivity
Recent genome-wide association studies (GWAS) identified Dusp8, a dual-specificity phosphatase targeting MAP kinases, as type 2 diabetes risk gene. Here, we unravel Dusp8 as gatekeeper in the hypothalamic control of glucose homeostasis in mice and humans. Male but not female Dusp8 loss-of-function m...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-17 | PXD019451 | Pride
Leptin Jnk Type2 diabetes Dusp8 
ProteomicsC-COMPASS: A user-friendly neural network tool profiles cell compartments at protein and lipid levels
Systematic proteomic organelle profiling methods including Protein Correlation Profiling and LOPIT have advanced our understanding of cellular compartmentalization. To manage the complexity of organelle profiling data, we introduce C-COMPASS, a user-friendly open-source software that employs a neura...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-07-18 | PXD056457 | Pride
Organelle proteomics 
ProteomicsA network-based approach reveals a novel mechanism of resistance to TKI-therapy in AML
Internal tandem duplications (ITDs) in the FLT3 gene are frequently identified and confer a poor prognosis in patient affected by acute myeloid leukemia (AML). The insertion site of the ITDs in FLT3 significantly impacts the sensitivity to tyrosine kinase inhibitors (TKIs) therapy, affecting patient...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD033953 | Pride
Tyrosine kinase inhibitors Ba/f3 cells Acute myeloid leukemia Midostaurin Flt3 Mouse Phosphoproteomics Tki Quizartinib Aml 
ProteomicsGlobal, neuronal, and beta-cell specific deletion of the insulin inhibitory receptor (inceptor) improves glucose homeostasis in diet-induced obese male mice
The insulin inhibitory receptor (inceptor) was recently identified as a key terminator of insulin and insulin-like growth factor 1 receptor (INSR/IGF1R) signaling in pancreatic 𝛽-cells12. Yet, the relevance of 𝛽-cell inceptor for glucose regulation through the INS1R/IGF1R axis has only been demons...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-17 | PXD046256 | Pride
Insulin inhibitory receptor Inceptor Insulin inceptor Diet-induced obesity Glucose homeostasis 
TranscriptomicsTranscription profiling of mouse wild type and Pias1 null cells in response to IFN treatments to study the effect of PIAS1 on interferon (IFN) signaling pathway
Microarray analysis was designed to study the effect of PIAS1 on interferon (IFN) signaling pathway by comparing the gene activation profiles of wild type and Pias1 null cells in response to IFN treatments. Microarray analysis was performed essentially following the manufacturer's instructions (Affy...
ORGANISM(S): Mus musculus 
2007-10-10 | E-GEOD-1552 | biostudies-arrayexpress
ProteomicsA Spatiotemporal Proteomic Map of Human Adipogenesis
White adipocytes function as the major energy reservoir in humans by storing large amounts of triglycerides. Their dysfunction is associated with metabolic disorders. However, the mechanisms underlying cellular specialization during adipogenesis remain unknown. Here, we generated a spatiotemporal pr...
ORGANISM(S): Homo sapiens (Human) 
2024-01-17 | PXD047412 | Pride
Bcaa Slc25a10 Adipocyte Wat Sgbs Adipogenesis Pcp Proteomic ruler Ocm Mpan Organelle proteomics C19orf12 Human 
ProteomicsAn unimolecular GIPR:GLP-1R:PPAR𝛼,𝛾,𝛿 quintuple agonist eliminates obesity and insulin resistance in mice.
Drugs to improve obesity-linked metabolic dysfunction are on the rise, with GLP-1:GIP co-agonism being effective in the management of obesity and type 2 diabetes, and with Lanifibranor (Lani), a nuclear acting small molecule triple agonist at the peroxisome proliferator-activated receptors alpha, ga...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-14 | PXD062990 | Pride
Gipr Glp1r Obesity 
ProteomicsProteomic changes in the hypothalamus after treatment with GLP-1RA, Tesaglitazar, or GLP-1RA/Tesaglitazar (GLP-1RA mediated Tesaglitazar delivery)
The peroxisome proliferator-activated receptors alpha and gamma (PPAR𝛼/𝛾) play important roles in the regulation of energy, lipid and glucose metabolism. Drugs targeting these proteins such as Fibrates and TZDs have both shown beneficial cardiovascular effects in clinical trials, which together wi...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-07 | PXD033653 | Pride
Tesaglitazar Glp-1ra Glp-1 Mouse Hypothalamus Targeted delivery 
ProteomicsAdipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo
Extracellular vesicles are membranous nanoparticles that convey signaling between cells, tissues and organs. By applying fluorescence tracing and SILAC-labeling paired with (phospho)proteomics, we identified the transfer of functional insulinotropic protein cargo via adipocyte-derived extracellular ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-03-11 | PXD037809 | Pride
Proteomics Insulin secretion Silac Extracellular vesicles Adipose tissue Phosphoproteomics Lc-ms/ms 
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