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ProteomicsHeart proteome in Cox10 depending on Opa1 processing
Mitochondrial fusion and fission accompany adaptive responses to stress and altered metabolic demands. Inner membrane fusion and cristae morphogenesis depends on Optic Atrophy 1 (Opa1), which is expressed in different isoforms and is cleaved from a membrane-bound, long to a soluble, short form. Here...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-10 | PXD048804 | Pride
Heart Cox10 Opa1 
UnknownIdentification of Au-hydrides as key intermediates in the reduction of Au(iii) prodrugs to active Au(i) species under protic conditions.
Not available
S-EPMC12777740 | biostudies-literature
UnknownCombined Blockade of TIGIT and CD39 or A2AR Enhances NK-92 Cell-Mediated Cytotoxicity in AML.
Not available
S-EPMC8657570 | biostudies-literature
ProteomicsRibonucleotide synthesis by NME6 fuels mitochondrial gene expression
Replication and expression of the mitochondrial genome depend on the sufficient supply ofnucleotide building blocks to mitochondria. Dysregulated nucleotide metabolism is detrimental tomitochondrial genomes and can destabilise mitochondrial DNA and trigger inflammation. Here, wereport that a mitocho...
ORGANISM(S): Homo sapiens (Human) 
2023-05-04 | PXD038391 | Pride
Mitochondria Ribonucleotide Nme6 Rntps Lc-ms/ms 
ProteomicsQuantitative Proteomics of Mouse Liver (FTO-KO,WT) in response to DEN injection
Single nucleotide polymorphisms in the FTO gene encoding a m6A demthylase are associated with obesity and cancer development. However, the functional role of FTO in the developemnt of progression of hepatocellular carcinoma (HCC) as a proteotypic obesity-associated cancer remains unclear. Here, we h...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-03 | PXD018223 | Pride
Fto Den Cul4a Liver 
ProteomicsAIFM1 KO and AIFM1del mutant HEK cell proteomics
Mitochondrial proteases regulate the dynamic properties of the organelle morphology and ensure functional plasticity at the cellular level. The metalloprotease OMA1 mediates constitutive and stress-inducible processing of its substrates in mitochondria, but the number of functionally characterized s...
ORGANISM(S): Homo sapiens (Human) 
2026-01-31 | PXD063602 | Pride
Aifm1 Mitochondrion Hek 
UnknownComparative oncology chemosensitivity assay for personalized medicine using low-coherence digital holography of dynamic light scattering from cancer biopsies.
Not available
S-EPMC10853550 | biostudies-literature
UnknownEctodysplasin signalling genes and phenotypic evolution in sculpins (Cottus).
Not available
S-EPMC4614746 | biostudies-literature
UnknownGenome-wide DNA methylation analysis pre- and post-lenalidomide treatment in patients with myelodysplastic syndrome with isolated deletion (5q).
Not available
S-EPMC8116243 | biostudies-literature
ProteomicsMulti-facetted proteomics of mitochondrial TMBIM5 deficient cell lines: Regulation of mitochondrial proteostasis by the proton gradient
Mitochondria adapt to different energetic demands reshaping their proteome. Mitochondrial proteases are emerging as key regulators of these adaptive processes. Here, we use a multi-proteomic approach to demonstrate regulation of the m-AAA protease AFG3L2 by the mitochondrial proton gradient, couplin...
ORGANISM(S): Homo sapiens (Human) 
2022-07-26 | PXD030095 | Pride
Cyclohexamide Hek Mitochondria Ghitm Hela Silac Afg3l2 Tmbim5 
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