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ProteomicsQuantitative phosphoproteomic analysis of the effect of deletion and duplication of the 16p11.2 genomic locus on induced pluripotent stem cells-derived neural progenitor cells
Deletion and duplication of the 16p11.2 genomic locus are associated with opposing changes in brain size. To determine cellular mechanisms that might underlie these opposing phenotypes, we performed quantitative phosphoproteomics on induced pluripotent stem cells (iPSC) derived neural progenitor cel...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD066614 | Pride
Taok2 Phosphorylation Neural progenitor cells Cilia length 
ProteomicsSILAC analysis of the effects of AS1411 on 3T3 cell proteome.
Here we conducted a SILAC analysis to study the effects of AS1411 on 3T3 cell proteome, and found that AS1411 consistently downregulated the expression of cholesterol biosynthesis enzymes
ORGANISM(S): Mus musculus (Mouse) 
2025-10-17 | PXD055162 | Pride
Cholesterol biosynthesis pathway Nucleolin As1411 Aptamer 
ProteomicsComparative proteomics of Coxiella Like Endosymbionts (CLEs) in the symbiotic organs of Rhipicephalus sanguineus ticks
Ticks (Acari: Ixodida) feed exclusively on blood which lacks essential nutrients such as vitamins and cofactors. These deficiencies are presumably complemented through specific symbiotic microorganisms such as Coxiella – Like Endosymbionts (CLEs) of Rhipicephalus ticks. CLE are localized in speciali...
ORGANISM(S): Coxiella-like endosymbiont of Rhipicephalus sanguineus complex 
2022-02-17 | PXD026817 | Pride
Comparative proteomics Arthropod endosymbionts Malpighian tubules Ovaries 
ProteomicsAnalysis of subcellular Importin b1 interactomes by BioID and BAR proximity labelling
Importin 1 (KPNB1) is a nucleocytoplasmic transport factor with critical roles in both cytoplasmic and nucleocytoplasmic transport, hence there is keen interest in the characterization of its subcellular interactomes. We found limited efficiency of BioID in detection of importin complex cargos, and ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-10-15 | PXD032728 | Pride
Axonal transport Kpnb1 Bar Bioid Proximity labeling 
ProteomicsSynaptic vesicles that store monoamines and glutamate differ in protein composition
Neuromodulators such as monoamines assure essential brain functions but relatively little is known about their mechanism of release. While recent work has advanced our knowledge of active zone architecture in dopamine axons, release machinery within the synaptic vesicle (SV) remains poorly understoo...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD073685 | Pride
Synaptic vesicles Tmt Vmat2 Dopamine release Vglut2 
ProteomicsMass spectrometry analysis of estrogen receptor α -interacting proteins.
Quantitative mass spectrometry analysis using tandem mass tags (TMT) labelling of estrogen receptor α (ERα) pull downs. Co-immunoprecipitated proteins using a anti Erα antibody were compared quantitatively with material recovered in a mock to identify ERα-interacting proteins.
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD025018 | Pride
Estrogen receptor Mrna binding Tmt Immunoprecipitation 
ProteomicsQuantitative analysis of the mouse brain phosphoproteome in mTORC2 KO mutants
Here we are using unbiased phosphoproteomics analyses to try to identify selective targets of mTORC2 in mouse brain.
ORGANISM(S): Mus musculus (Mouse) 
2023-10-20 | PXD045878 | Pride
Mouse Tmt Mtorc2 Phosphorylation 
ProteomicsPhospho-proteome profiling in human induced pluripotent stem cells and derived human neurons reveals targets of TBK1 in ALS/FTD-1 associated autophagy networks
TBK1 (TANK-binding kinase 1) is a ubiquitously expressed IKK-related kinase implicated in diverse cellular processes, including interferon signaling, apoptosis, and autophagy. Loss-of-function variants in TBK1 are strongly associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dement...
ORGANISM(S): Homo sapiens (Human) 
2025-09-11 | PXD068150 | Pride
Autophagy Neurons Tnk1 Phosphorylation 
ProteomicsProteomic analysis of vitreous in WT and CD11b KO mice.
Our data support that following optic nerve crush injury, ocular infiltration of immune cells causes damage to the retinal vasculature and compromises the integrity of the blood-retina barrier (BRB). Functional ablation of integrin alphaM (CD11b) attenuates immune cell trafficking, protects the BRB,...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-05 | PXD045885 | Pride
Mouse Tmt Vitreous Itgam. Cd11b Label free 
ProteomicsMapping Axon Initial Segment Structure and Function by Iterative Proximity Biotinylation
We constructed AIS-targeted biotin ligase by generating fusion proteins of BirA* with NF186, Ndel1, and Trim46; these chimeras mapped the molecular organization of intracellular membrane, cytosolic, and microtubule compartments of the AIS, respectively
ORGANISM(S): Rattus norvegicus (Rat) 
2020-01-13 | PXD016272 | Pride
Bioid Axon initial segments 
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