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ProteomicsMonitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication, Batch 1
Base lesions in DNA can stall the replication machinery or induce mutations if bypassed. Consequently, lesions must be repaired before replication or in a post-replicative process to maintain genomic stability. Base excision repair (BER) is the main pathway for repair of base lesions, but how BER is...
ORGANISM(S): Homo sapiens (Human) 
2017-11-23 | PXD004288 | Pride
Ber Ipond Batch 1 Orbitrap Ssbr Replication Quantification Replisome Label free 
ProteomicsIdentification of BER/SSBR proteins and the DNA glycosylases MPG, UNG2, MYH, NTH1, NEIL1 and NEIL3 in replisomes Batch 3
Base lesions in DNA can stall the replication machinery or induce mutations if bypassed. Consequently, lesions must be repaired before replication or in a post-replicative process to maintain genomic stability. Base excision repair (BER) is the main pathway for repair of base lesions, but how BER is...
ORGANISM(S): Homo sapiens (Human) 
2024-06-07 | PXD004324 | Pride
Ber Batch 3 Ipond Orbitrap Ssbr Replication Quantification Replisome Label free 
ProteomicsMonitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication, Batch 2
Base lesions in DNA can stall the replication machinery or induce mutations if bypassed. Consequently, lesions must be repaired before replication or in a post-replicative process to maintain genomic stability. Base excision repair (BER) is the main pathway for repair of base lesions, but how BER is...
ORGANISM(S): Homo sapiens (Human) 
2017-11-23 | PXD004494 | Pride
Ber Ipond Batch 2 Orbitrap Ssbr Replication Quantification Replisome Label free 
ProteomicsPCNA regulates metabolism by stabilizing ENO1 and 6PGD
The essential roles of PCNA as a scaffold protein in DNA replication and repair are well established, while its more recently discovered cytosolic roles are less explored. Alpha-enolase (ENO1) and 6-phosphogluconate dehydrogenase (6PGD), important proteins in glycolysis and the Pentose Phosphate Pat...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD028314 | Pride
Glycolysis Pi3k/akt pathway Cell signaling Apim-peptide Atx-101 Apim 
ProteomicsA dual-mechanism antimicrobial peptide with antimutagenic activity targets the replisome and induces cell envelope stress
To combat the growing threat of multidrug-resistant bacteria, we need to develop novel antibiotics with unique modes of action. This study investigates the antibacterial properties of BTP-001 towards Escherichia coli. BTP-001 is a β-clamp targeting antimicrobial peptide containing an AlkB homologu 2...
ORGANISM(S): Escherichia coli Bacteria 
2025-08-24 | PXD055475 | Pride
Escherichia coli 
ProteomicsNucleoside Analogues are Potent Inducers of Bacterial Mutagenesis
Drugs targeting DNA and RNA in mammalian cells or viruses can also affect bacteria present in the host and thereby induce the bacterial SOS system. This has the potential to increase mutagenesis and the development of antimicrobial resistance (AMR). Here we have examined nucleoside analogues (NAs) ...
ORGANISM(S): Escherichia coli 
2021-07-15 | PXD025370 | Pride
Na -clamp Tls Mdr Pol v Nrtis Sos Amr 
ProteomicsPCNA has specific functions in regulation of metabolism in haematological cells
PCNA´s essential roles in DNA replication and repair are well established, while it’s recently discovered non-canonical roles in cellular signalling and regulation of metabolism are less explored. Recent data has indicated that PCNA has a specific non-canonical role in cells of haematological origin...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD017474 | Pride
Pi3k/akt pathway Metabolomics Systems-level study Signalome Cell signalling Redox metabolism Apim Central carbon metabolism Kinome 
ProteomicsTargeting PCNA in a subgroup of Multiple Myeloma cells inhibits the glycolysis and pentose phosphate pathway
PCNA is an essential protein in all cells with multiple well-known function in DNA replication and DNA repair. Recently, PCNA was shown to be involved in regulation of cellular signalling and central carbon metabolism via stabilizing the metabolic enzymes ENO1 and 6PGD. Furthermore, ATX-101, a PCNA ...
ORGANISM(S): Homo sapiens (Human) 
2024-11-25 | PXD033510 | Pride
Targeting Pentose phosphate pathway Tk Multiple myeloma Cells Glycolysis Mib assay Pcna 
ProteomicsTargeting PCNA in a subgroup of Multiple Myeloma cells inhibits the glycolysis and pentose phosphate pathway (batch TK9)
PCNA is an essential protein in all cells with multiple well-known function in DNA replication and DNA repair. Recently, PCNA was shown to be involved in regulation of cellular signalling and central carbon metabolism via stabilizing the metabolic enzymes ENO1 and 6PGD. Furthermore, ATX-101, a PCNA ...
ORGANISM(S): Homo sapiens (Human) 
2024-11-25 | PXD033531 | Pride
Targeting Pentose phosphate pathway Tk Multiple myeloma Cells Glycolysis Mib assay Pcna 
ProteomicsPCNA-targeting peptide modifies and increases the response to EGFR/HER2/VEGF inhibition in breast cancer cells
To combine inhibition of EGFR/HER2 and targeting of the cytosolic roles of PCNA using the APIM-peptide, and study the anti-cancer effects of this combinatory therapy in in vitro and in vivo breast cancer models.
ORGANISM(S): Mus musculus (Mouse) 
2020-01-15 | PXD011044 | Pride
Tnbc- triple negative breast cancer Pi3k- the phosphoinositide 3-kinase Her2/erbb2- human epidermal growth factor receptor 2 Signaling pathways Egfr- epidermal growth factor receptor Combination therapy Pcna- proliferating cell nuclear antigen Multi-targeting therapy Pr- progesterone receptor Mapk- mitogen-activated protein kinase Autophagy Vegf- vascular endothelial growth factor Er- estrogen receptor 
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