Sort   by:  
 Page size 
ProteomicsIdentification by activity-based probes of a new Plasmodium falciparum E2 ubiquitin conjugating enzyme
The ubiquitin-proteasome system (UPS) is essential for Plasmodium falciparum survival and represents a potential target for antimalarial therapies. We utilized a ubiquitin-based activity probe (Ub-Dha) to capture active ubiquitin conjugating machinery during asexual blood-stage development. Several ...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2025-03-13 | PXD056473 | Pride
Plasmodium falciparum Activity proteomics Ubiquitin 
ProteomicsUSP24 is an ISG15 cross-reactive deubiquitinase that mediates IFN-I production by de-ISGylating the RNA helicase MOV10
The interferon Stimulated Gene-15 (ISG15) is a ubiquitin-like modifier induced by type I Interferon (IFN-I) and plays a crucial role in the innate immune response against viral infections. ISG15 is conjugated to target proteins by an enzymatic cascade through a process called ISGylation. While USP18...
ORGANISM(S): Homo sapiens (Human) 
2026-05-13 | PXD055843 | Pride
Human Innate immunity Ubiquitomics Isg15 Immunology Usp24 
ProteomicsStructural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6
Certain Inhibitors of apoptosis (IAP) family members are sentinel proteins preventing untimely cell death by inhibiting caspases. Antagonists including second mitochondria-derived activator of caspase (SMAC) regulate IAPs, driving cell death. Baculoviral IAP repeat-containing protein 6 (BIRC6), a gi...
ORGANISM(S): Homo sapiens (Human) 
2023-03-08 | PXD039954 | Pride
Ap-ms Birc6 Structural biology Cell death Ubiquitomics Biochemistry 
ProteomicsAn unconventional integrin promotes human immunityAn unconventional integrin promotes human immunity
Cancer remains one of the leading causes of mortality worldwide, with increasing public health interest towards immunological-based approach in disease treatments. Enrichment of certain cell population, namely the CD103+ tissue-resident memory T (Trm) cells has been associated with better clinical p...
ORGANISM(S): Homo sapiens (Human) 
2024-07-30 | PXD045989 | Pride
Human Cancer immunology Interactomics 
ProteomicsISG15 promotes PARP inhibitor resistance in BRCA1-deficient cells by facilitating DNA replication and repair
The use of poly(ADP-ribose) polymerase inhibitors (PARPi) has proven largely successful in targeting BRCA1/2-mutated tumours. However, the emergence of PARPi-resistant disease can reduce the efficacy of this treatment, posing significant challenges in the clinic. Here, we use multiple models of BRCA...
ORGANISM(S): Homo sapiens (Human) 
2026-08-18 | PXD069001 | Pride
Dna damage Dna replication Cancer Parp Isg15 Brca 
ProteomicsUSP28 deletion and small molecule inhibition destabilises c-Myc and elicits regression of squamous cell lung carcinoma
Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an incidence of over 600,000 cases per year. Treatment options are limited, and patient 5-year survival rate is less than 5%. The ubiquitin specific protease 28 (USP28) has been implicated in tumorigenesis through its s...
ORGANISM(S): Homo sapiens (Human) 
2024-07-30 | PXD023339 | Pride
Abpp Usp28 Lung squamous cell carcinoma (lscc) 
ProteomicsRegulation of the endosomal SNX27 retromer by OTULIN
OTULIN specifically hydrolyzes methionine1 (Met1)-linked ubiquitin chains conjugated by LUBAC (linear ubiquitin chain assembly complex). Using mass spectrometry, we discovered an interaction of OTULIN with SNX27 (sorting nexin 27), an adaptor of the endosomal retromer complex responsible for protein...
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD012082 | Pride
Acitivity-based probe Otulin Interactome 
ProteomicsDeep analysis of the USP18-dependent ISGylome and proteome unveils important roles for USP18 in tumour cell antigenicity and radiosensitivity
The deubiquitylating enzyme USP18 is a major negative regulator of the interferon (IFN) signalling cascade. IFN pathways contribute to resistance to conventional chemotherapy, radiotherapy, and immunotherapy and are often upregulated in certain tumours, including breast, lung, and colon tumours. USP...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD018299 | Pride
Human Cancer Deisgylating enzyme Proteomics Usp18 Isg15 Immunotherapy 
ProteomicsUSP16 is an ISG15 cross-reactive deubiquitinase targeting a subset of metabolic pathway-related proteins
The ubiquitin-like modifier ISG15 can modulate host and viral proteins to restrict viral and microbial infections, and act as a cytokine. Its expression and conjugation are strongly up-regulated by type I interferons. Here we identify the deubiquitinating enzyme USP16 as an ISG15 cross-reactive prot...
ORGANISM(S): Homo sapiens (Human) 
2023-11-17 | PXD043553 | Pride
Usp16 Innate immunity Metabolic enzyme Isg15 
ProteomicsUSP9X controls the resolution of stalled ribosomes
When a ribosome stalls during translation, it runs the risk of collision with a trailing ribosome. Such an encounter leads to the formation of a stable di-ribosome complex, which needs to be resolved by a dedicated machinery. The initial stalling and the subsequent resolution of di-ribosomal complex...
ORGANISM(S): Homo sapiens (Human) 
2021-01-26 | PXD018662 | Pride
Znf598 Ribosomal stalling Makorin Ubiquitin Deubiquitylase Usp9x Dub inhibitor Translation 
Sort   by:  
 Page size