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ProteomicsArchaea produce peptidoglycan hydrolases that kill bacteria
The social life of archaea is poorly understood. In particular, even though competition and conflict are common themes in microbial communities, there is scant evidence documenting antagonistic interactions between archaea and their abundant prokaryotic brethren: bacteria. Do archaea specifically ta...
ORGANISM(S): Haloferax volcanii SB1 
2026-02-07 | PXD064732 | Pride
Archaea Peptidoglycan hydrolase 
ProteomicsLysosomal sequestration of PARP inhibitors drives heterogeneous accumulation in ovarian cancer to increase efficacy
PARP inhibitors have had a transformative impact in the treatment of high-grade serous ovarian cancer (HGSOC), but resistance remains a clinical hurdle. Increased expression of ABC drug efflux transporters has been identified as a resistance mechanism in patients but whether intracellular concentrat...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD057265 | Pride
Rucaparib High grade serous ovarian cancer Abcb1/mdr1 Niraparib Spatial transcriptomics Patient derived explants Lysosomes Parp inhibitors Mass spectrometry imaging 
ProteomicsEffects of Canavanine on Human Glioblastoma Cells under Arginine Deprivation
We investigated the effect of canavanine (toxic Arg analogue) treatment on U251MG and U87MG cell lines using a variety of methods including proteomics. Since 3rd isotope of unmodified peptide cannot be resolved from canavanine containing peptide even at extremely high resolutions of 480K we incorpor...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD019044 | Pride
Canavanine Silac Human 
ProteomicsLabel free IMS-MSE protein quantification for plant Golgi protein localisation and abundance
Golgi resident proteins in Arabidopsis thaliana are challenging to quantify since the abundance of this organelle is relatively low within the cell. In this study an organelle fractionation approach, targeting the Golgi apparatus, was combined with a label free quantitative MS, data-independent acqu...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2016-07-07 | PXD001056 | Pride
Arabidopsis thaliana Mse Hdmse Lopims Lopit Organelle proteomics Ims-mse Data-independent acquisition Absolute quantitation 
ProteomicsPBK/TOPK mediates Ikaros, Aiolos and CTCF displacement from mitotic chromosomes and alters chromatin accessibility at selected C2H2-zinc finger protein binding sites
PBK/TOPK is a mitotic kinase implicated in haematological and non-haematological cancers. Here we show that the key haemopoietic regulators Ikaros and Aiolos require PBK-mediated phosphorylation to dissociate from chromosomes in mitosis. Eviction of Ikaros is rapidly reversed by addition of the PBK-...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-21 | PXD057894 | Pride
C2h2-zinc finger proteins Pbk/topk Chromosomes Mitosis Phosphorylation 
ProteomicsHistone H3 lysine 4 trimethylation regulates RNA polymerase II promoter-proximal pause-release
Trimethylation of histone H3 lysine 4 (H3K4me3) is associated with transcriptional start sites and proposed to regulate transcription initiation. However, redundant functions of the H3K4 SET1/COMPASS methyltransferase complexes complicate elucidation of the specific role of H3K4me3 in transcriptiona...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-14 | PXD028858 | Pride
Histone Rna polymerase ii 
ProteomicsReducing Dietary Protein Enhances the Anti-tumor Effects of Chemotherapy
Diet is believed to be an important mediator of oncogenesis and response to anti-cancer therapies, although, no evidence-based dietary guidelines exist for patients with cancer. Limiting protein intake can suppress tumor growth by both inducing nutrient stress and enhancing anti-tumor immunity. Howe...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-07 | PXD052110 | Pride
Cancer Cgas-sting Diet Chemotherapy 5-fu 
ProteomicsThe metabolic background is a global player in Saccharomyces gene expression epistasis
The transcriptome, proteome and metabolome of 16 S.cerevisiae backgrounds, combinatorially perturbed in HIS3, LEU2, URA3 and MET15strains are compared. The project was jointly supervised by Kathryn Lilley and Markus Ralser. Transcriptome data has been deposited at ArrayExpress under accession
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-01-05 | PXD001491 | Pride
S. cerevisiae 
ProteomicsThe Histone Demethylase KDM5C Functions as a Tumor Suppressor in AML by Repression of B ivalently M arked Immature Genes
To uncover novel epigenetic regulators in AML, we performed an in vivo short hairpin RNA (shRNA) screen in the context of Cebpa mutant AML. This led to the identification of the Histone 3 Lysine 4 (H3K4) demethylase, KDM5C, as a novel tumor suppressor in AML. KDM5C potentially functions as a transcr...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD016568 | Pride
Human Leukemia Kdm5c 
ProteomicsWNK1 signalling regulates amino acid transport and mTORC1 activity to sustain AML growth
The lack of curative therapies for acute myeloid leukaemia (AML) remains an ongoing challenge despite recent advances in the understanding of the molecular basis of the disease. Here we identify the WNK1-OXSR1/STK39 pathway as a previously uncharacterised dependency in AML. We show that genetic depl...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-02 | PXD041902 | Pride
Wnk1 Phosphoproteomics Aml Mtor 
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