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ProteomicsPX-12 Modulates Vorinostat-induced acetylation and methylation marks in CAL 27 cells
The hypoxic tumor microenvironment (TME) is a common hallmark of solid cancers, including oral squamous cell carcinoma (OSCC). Hypoxia is predominantly regulated by the hypoxia-inducible factor-1 alpha (HIF-1α) and can alter the histone acetylation and methylation profile involved in drug resistance...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053244 | Pride
Oral squamous cell carcinoma (oscc) Hypoxia Histone acetylation Histone methylation Vorinostat 
ProteomicsA dynamic and combinatorial histone code drives malaria parasite asexual and sexual development
Histone post-translational modifications (PTMs) are frequently co-occurring on the same chromatin domains or even the same molecule. It is now established that these ‘histone codes’ are the result of cross-talk between enzymes that catalyse multiple PTMs with univocal readout as compared to these PT...
ORGANISM(S): Plasmodium falciparum V1 
2022-05-19 | PXD030181 | Pride
Malaria Middle-down mass spectrometry proteomics Post-translational modification Parasite Ptm Gametocyte Histone code Plasmodium falciparum 
ProteomicsMethionine restriction extends yeast lifespan by activating non-nitrogen-starvation-induced autophagy through limiting methylation of protein phosphatase 2A
Methionine restriction (MR) extends the lifespan and healthspan of numerous eukaryotic organisms, but the molecular mechanisms at play are unclear. Here we find that the ability of MR to extend the budding yeast chronological and replicative lifespans is the consequence of reduced methionine convers...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-06-15 | PXD069602 | Pride
Autophagy Methylation Longevity Lifespan Phosphorylation Methionine restriction 
ProteomicsDecoding Cocaine-Induced Proteomic Adaptations in the Mouse Nucleus Accumbens
Cocaine use disorder (CUD) is a chronic neuropsychiatric condition characterized by a compulsion to use cocaine, resulting from enduring cellular and molecular adaptations. Among substance use disorders (SUDs), CUD is notable for its rising prevalence and the lack of approved pharmacotherapies. The ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD050162 | Pride
Proteomics Nucleus accumbens Cocaine Chromatin 
ProteomicsIntrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity
In development, pioneer transcription factors access silent chromatin to reveal lineage-specific gene programs. The structured DNA-binding domains of pioneer factors have been well characterized, but whether and how low-complexity intrinsically disordered regions (IDRs) affect chromatin and control ...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-16 | PXD043586 | Pride
Tcf-1 T-cells L1 Transcription factor Idrs 
ProteomicsDynamic N-terminal regulation couples GNMT folate feedback to methyl-donor homeostasis
One carbon metabolism supports essential cellular functions, including biomolecule methylation, nucleotide and polyamine synthesis, and redox homeostasis. These processes depend on maintenance of S-adeno-sylmethionine (SAM) homeostasis. Although all methyltransferases consume SAM, only a subset appe...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-18 | PXD078525 | Pride
Sam Folate One carbon metabolism Methylation Gnmt Methionine 
ProteomicsMyofibroblast-specific Smad7 protects the pressure-overloaded heart by restraining collagen deposition and denaturation, and by inhibiting paracrine macrophage activation
Rationale: Expansion and activation of cardiac fibroblasts contributes to adverse remodeling, fibrosis and dysfunction in the pressure-overloaded heart. Although early fibroblast TGF-β/Smad3 activation protects the pressure overloaded heart by preserving the matrix, sustained TGF-β activation may be...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-28 | PXD043577 | Pride
Heart Tgf-beta Fibrosis Smad7 
ProteomicsMyofibroblast-specific Smad7 protects the pressure-overloaded heart by restraining collagen deposition and denaturation, and by inhibiting paracrine macrophage activation
Rationale: Expansion and activation of cardiac fibroblasts contributes to adverse remodeling, fibrosis and dysfunction in the pressure-overloaded heart. Although early fibroblast TGF-β/Smad3 activation protects the pressure overloaded heart by preserving the matrix, sustained TGF-β activation may be...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-28 | PXD049057 | Pride
Heart Proteomics Macrophage Smad7 Pressure 
ProteomicsProductive mRNA chromatin escape is promoted by PRMT5 methylation of SNRPB
Protein Arginine Methyltransferase 5 (PRMT5) regulates RNA splicing and transcription by symmetrically dimethyl-ates arginine residues (Rme2s/SDMA) in many RNA binding proteins. However, the mechanism by which PRMT5 couples splicing to transcriptional output is unknown. Here, we demonstrate that a m...
ORGANISM(S): Homo sapiens (Human) 
2026-10-26 | PXD054308 | Pride
Prmt5 Transcription Methylation Snrpb Chromatin 
ProteomicsMapping the Toxoplasma gondii cytosolic interactome by crosslinking mass spectrometry and machine learning
Protein–protein interactions (PPIs) are fundamental to cellular processes and pathogen biology, yet remain undercharacterized in the human parasite Toxoplasma gondii. Here, we apply crosslinking mass spectrometry (XL-MS) to map the cytosolic interactome of T. gondii tachyzoites at proteome scale. Us...
ORGANISM(S): Toxoplasma gondii type I 
2025-07-26 | PXD062479 | Pride
Machine learning Cytosol Protein–protein interactions Dense granule proteins Crosslinking mass spectrometry Interactome Dsbso Host-pathogen interactions Structural mapping Toxoplasma gondii Lightgbm Parasite proteomics Ribosome Proteasome 
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