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ProteomicsLFQ proteomics of mouse GABAergic interneurons during traumatic brain injury
Unilateral Traumatic Brain Injury (TBI) causes functional disturbances of the neuronal networks spreading even to the undamaged cortical hemisphere. The phenomenon, referred to as transhemispheric diaschisis, is suggested to be mediated by an imbalance of the strength of glutamatergic, excitatory vs...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-03 | PXD023551 | Pride
L-type voltage-gated calcium channel Traumatic brain injury Inhibitory interneurons Neuroplasticity 
ProteomicsFive Wheat Species Flour Proteomics by LC-MS/MS
LC-MS/MS-based LFQ proteomics of 150 wheat full-kernel flours from five different wheat species (common wheat, spelt, durum wheat, emmer, einkorn) grown at three different locations.
ORGANISM(S): Triticum aestivum (Wheat) 
2023-03-30 | PXD028676 | Pride
Triticum aestivum Einkorn Spelt Udmse Lfq Wheat Common wheat Durum wheat Emmer Lc-ms/ms 
ProteomicsProteomic analysis of brain region and gender-specific synaptic protein expression in the adult mouse brain
In a wide range of synaptopathies a sex/gender bias in prevalence and clinical course has been reported. Therefore, analysis of the synaptic proteinaceous inventory in different brain regions in males and females is very desirable in understanding the molecular basis of brain function and the etiolo...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-17 | PXD015610 | Pride
Sex/gender bias Prefrontal cortex Hippocampus Cerebellum Striatum Synaptic junction Label-free quantification Data-independent acquisition 
ProteomicsProteomic Sample Preparation in the Low Microgram Range – A Critical Evaluation of Current Workflows
Efficient and reproducible sample preparation is a prerequisite for any robust and sensitive quantitative bottom-up proteomics workflow. Over the past years, several protocols been specifically developed for the preparation of samples, which are limited in quantity. In the present study, we carried ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2018-05-11 | PXD006760 | Pride
Single-pot solid-phase-enhanced sample preparation (sp3) Filter-aided sample preparation (fasp) In-stagetip digestion (ist) Sample preparation Bottom-up proteomics 
ProteomicsMurine keratinocytes NFAT5 knockout secretome LC-MS/MS
The skin protects the human body against dehydration and harmful challenges. Keratinocytes (KCs) are the most frequent epidermal cells, and it is anticipated that KC-mediated transport of Na+ ions creates a physiological barrier of high osmolality against the external environment. We studied in KCs ...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-16 | PXD028675 | Pride
Mouse Keratinocyte Mus musculus Udmse Lfq Nfat5 Secretome Lc-ms/ms 
ProteomicsHybrid label-free quantification proteomics and QconCAT-assisted quantification of amylase-trypsin inhibitors from flours of 150 wheat varieties (3 field locations) by LC-MSE
Wheat (Triticum aestivum ssp. aestivum) contributes to 20% of the human protein supply, delivers essential amino acids and is of fundamental importance for bread and pasta quality. Wheat proteins are also involved in adverse human reactions like celiac disease, wheat allergy and the non-celiac wheat...
ORGANISM(S): Triticum aestivum (Wheat) 
2021-09-10 | PXD023654 | Pride
Mse Breeding Amylase-trypsin inhibitors (atis) Synapt g2-s Proteomics Wheat varieties Qconcat Label-free quantification (lfq) Non-celiac wheat sensitivity (ncws) Data-independent acquisition (dia) 
ProteomicsHybrid QconCAT-based Targeted Absolute and Data-independent Acquisition-based Label-free Quantification Enables In-depth Proteomic Characterization of Wheat ATI Extracts
In this study, we present a novel hybrid data-independent acquisition LC-MS approach, combining QconCAT technology with short microflow LC gradients and DIA and apply the method towards the quantitative proteome analysis of ATI extracts from wheat flour. The novel method is fast, robust and reproduc...
ORGANISM(S): Triticum aestivum (Wheat) 
2021-04-22 | PXD021381 | Pride
Wheat Dia Data-independent acquisition Qconcat Absolute quantification Microflow lc-ms Ati Triticum Amylase-trypsin inhibitor 
ProteomicsProteogenomics analysis unveils a novel TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas
Papillary thyroid cancer (PTC) is the most common type of endocrine malignancy. From a set of PTC patients whose tumor did not harbour any BRAF or RAS mutations, a 35 years old male patient’s normal, primary tumor and lymph node (LN) metastatic tissues was subjected to genomics and proteomics analys...
ORGANISM(S): Homo sapiens (Human) 
2020-04-02 | PXD016739 | Pride
Precision medicine Tfg-ret Ptc Ret Usp9x Huwe1 Usp7 
Proteomics1GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton
Charcot-Marie-Tooth (CMT) disease 4A is an autosomal-recessive polyneuropathy caused by mutations of ganglioside-induced differentiation-associated protein 1 (GDAP1), a putative glutathione transferase, which affects mitochondrial shape and alters cellular Ca2+homeostasis. Here, w...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD024555 | Pride
Mouse Gdap1 Pulldown Sp3 Lc-udmse Primary cortical neurons 
ProteomicsLFQ proteomics of isolated GABAergic interneurons from mouse models of traumatic brain injury
Posttraumatic epilepsy (PTE) is a major public health concern and strongly contributes to human epilepsy cases worldwide. However, their effective treatment and prevention remains a matter of intense research. The present study provides new insights into the GABAA-receptor-stabilizing protein ubiqui...
ORGANISM(S): Mus Musculus (mouse) 
2022-07-14 | PXD031368 | JPOST Repository
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