Introduction: Early life is characterized by heightened susceptibility to infections and is recognized as a major determinant of the immune system development and the overall health for the entire human lifespan. However, our knowledge of the development of the neonatal immune system is incomplete, ...
This manuscript describes methodology for the meta-analysis of published proteomics datasets from multiple publications to mine for cerebrospinal fluid (CSF)-based diagnostic biomarkers for Alzheimer’s disease (AD).The identified biomarkers are then validated in an independent cohort analyzed in hou...
Tuberculosis is the leading killer among infectious diseases worldwide. The rise of multi-drug resistance has prompted new approaches for tuberculosis drug development, including inhibition of virulence determinants and of signaling cascades that control many downstream pathways. Here we used a mult...
In high-throughput LC-MS/MS-based proteomics, information about the presence and stoichiometry of post-translational modifications is normally not readily available. To overcome this problem we developed multiFLEX-LF, a computational tool that builds upon FLEXIQuant and FLEXIQuant-LF, which detect m...
We established a spectral library for data-independent analysis of human plasma samples, using a pooled plasma sample from Danish adults. The samples were prepared for proteome analysis using an in-house developed protocol consuming one microliter of plasma per sample, and the tryptic digest and sub...
Method development for high-throughput, sample-sparing platelet proteomics from previously frozen plasma and application of this method to a COVID-19 cohort
Synovial fluid in an articulating joint contains proteins derived from blood transudates, and proteins that are produced by cells within joint tissues, such as synovium, cartilage, ligament, and meniscus. The proteome composition of healthy synovial fluid is not fully understood. Also not fully deli...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig)
Three different sample types (HeLa lysate, human CSF and human Urine) that were prepared with MStern Blot and FASP. For each sample type there are four replicates.
