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ProteomicsPeroxiredoxin 6 protects irradiated cells from oxidative stress and shapes their senescence-associated cytokine landscape, redox proteomic analysis
Cellular senescence is a complex stress response defined as an essentially irreversible cell cycle arrest mediated by the inhibition of cell cycle-specific cyclin dependent kinases. The imbalance in redox homeostasis and oxidative stress have been repeatedly observed as one of the hallmarks of the s...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028780 | Pride
Peroxiredoxin 6 Cellular senescence Silac-iodotmt Ionizing radiation Redox proteomics 
ProteomicsImpact of anesthetics on rat hippocampus and neocortex: a comprehensive proteomic study based on label-free mass spectrometry
In this work, in vivo experiment simulating a general anesthesia and ICU sedation was designed to assess the impact of two intravenous (midazolam, dexmedetomidine) and two inhalational (isoflurane, desflurane) agents to neuronal centers for cognition (neocortex), learning, and memory (hippocampus). ...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-05-23 | PXD045159 | Pride
Hippocampus Neocortex Long-term potentiation Anesthetics Gaba signaling Vdac Apoptosis Nmdar Label-free proteomics 
ProteomicsQuantification of cellular protein and redox imbalance using SILAC-iodoTMT methodology
A new analytical method capable of simultaneously assessing cellular protein expression and cysteine oxidation would provide a valuable tool for the field of cysteine-targeted biology. Here, we show a workflow based on protein quantification using metabolic labeling and determination of cysteine oxi...
ORGANISM(S): Homo sapiens (Human) 
2026-09-03 | PXD012504 | Pride
Cysteine Liquid chromatography/mass spectrometry Silac-iodotmt labeling Peroxiredoxin Proteome Redoxome 
ProteomicsComprehensive proteomic investigation of infectious and inflammatory changes in late preterm prelabour rupture of membranes
Preterm prelabour rupture of membranes beyond the 34th week of gestation (late PPROM) is frequently associated with the risk of the microbial invasion of the amniotic fluid (MIAC) and histological chorioamnionitis (HCA). Hence, we employed a Tandem Mass Tag-based approach to uncover amniotic fluid p...
ORGANISM(S): Homo sapiens (Human) 
2020-10-22 | PXD020329 | Pride
Amniotic fluid proteome Tandem mass tag-based lc-ms/ms Late pprom Miac Hca 
ProteomicsGpsB coordinates StkP signalling as a PASTA kinase adaptor in Streptococcus pneumoniae cell division
StkP, the Ser/Thr protein kinase of the major human pathogen Streptococcus pneumoniae, monitors cell wall signals and regulates growth and division in response. In vivo, StkP interacts with GpsB, a cell division protein required for septal ring formation and closure that affects StkP-dependent phosp...
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2024-09-25 | PXD051731 | Pride
Phosphorylation Gpsb Streptococcus pneumoniae 
ProteomicsQuantification of intra-amniotic inflammation in late preterm prelabour rupture of membranes
Preterm prelabour rupture of membranes (PPROM) complicated by intra-amniotic inflammation (IAI) represents a substantial portion of preterm birth cases. Currently, IAI is frequently defined as amniotic fluid IL-6 concentration above 2600 pg/mL However, the amniotic fluid IL-6 concentration was never...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD057800 | Pride
Intra-amniotic inflammation Late pprom Amniotic fluid proteome Il-6 Iai Lc-ms/ms 
ProteomicsMethodological aspects of µLC-MS/MS for wide-scale proteomic analysis of anthracycline-induced cardiomyopathy
The effort to utilize microflow liquid chromatography for deep-scale proteomic analysis (µLC-MS/MS) is still growing. In this work, we utilized two-dimensional LC separation and peptide derivatization by tandem mass tag and assessed the capability of µLC-MS/MS to reveal protein changes associated wi...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2025-04-30 | PXD047014 | Pride
Cardiotoxicity Tmt 2d-separation Microlc-ms/ms Daunorubicin 
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