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ProteomicsDiscovery and Development of CD70 As a Cellular Therapy Target in High Risk Multiple Myeloma
Even in the BCMA CAR-T era, multiple myeloma (MM) patients with high-risk genotypes have the poorest outcomes. We thus leveraged MMRF CoMMpass data to identify potential novel surface immunotherapeutic targets in high-risk MM. As described below, we focused on CD70, an immunotherapeutic target known...
ORGANISM(S): Homo sapiens (Human) 
2025-11-27 | PXD048492 | Pride
Car-t Cd 70 Multiple myeloma Immunotherapy 
ProteomicsA CRISPR-engineered Isogenic Model Reveals Altered Neuronal Phenotypes of the 22q11.2 A-B Syndromic Deletion
The 22q11.2 deletion syndrome (22q11.2DS) is the most common copy number variant (CNV)-associated syndrome, leading to congenital and neuropsychiatric anomalies. Patient-derived, induced pluripotent stem cell (iPS) models have provided important insight into the mechanisms of phenotypic features of ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-11 | PXD032075 | Pride
Isogenic Neurons Proteomics Cnv Ipsc 22q11.2ds Crispr Xenotransplant 
ProteomicsProteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma
Resistance to proteasome inhibitors (PIs) is a ubiquitous clinical concern in multiple myeloma. We proposed that signaling-level responses after PI would reveal new means to enhance efficacy. Unbiased phosphoproteomics after the PI carfilzomib surprisingly demonstrated the most prominent phosphory...
ORGANISM(S): Homo sapiens (Human) 
2020-02-21 | PXD012172 | Pride
Cancer Multiple myeloma Splice factor Spliceosome Lc-msms phosphoproteomics Proteasome inhibition Splicing Alternative splicing 
ProteomicsLC-MSMS of cell secretome for MAP1LC3B interactors
Description Growing evidence implicates autophagy in cell secretion. Identifying the repertoire of proteins involved with autophagy dependent secretions is key for understanding the underlying mechanism. We initially use a proximity-dependent biotinylation proteomics strategy to label protein that e...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD015479 | Pride
Autophagy Proximity-tagged ms Exosome Bira Secretome 
ProteomicsLC-MSMS of cell secretome for MAP1LC3B interactors
Growing evidence implicates autophagy in cell secretion. Identifying the repertoire of proteins involved with autophagy dependent secretions is key for understanding the underlying mechanism. We use a proximity-dependent biotinylation proteomics strategy to label protein that engage the autophagy ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD006541 | Pride
Lc-msms Autophagy Silac Map1lc3b Human Bioid Secretome 
ProteomicsEssential role of Protein kinase R in the pathogenesis of pulmonary veno-occlusive disease
Pulmonary veno-occlusive disease (PVOD) is a rare and severe form of pulmonary arterial hypertension, characterized by progressive obstruction of small pulmonary vessels and a lack of effective therapeutic options. Our previous research, utilizing a mitomycin C (MMC)-induced rat model, demonstrated ...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-11 | PXD066782 | Pride
Protein kinase r Proteomics Pvod 
ProteomicsDefining the cell surface proteomic landscape of multiple myeloma reveals immunotherapeutic strategies and biomarkers of drug resistance
The myeloma cell surface proteome (“surfaceome”) not only determines tumor interaction with the microenvironment but serves as an emerging arena for therapeutic development. Here, we use glycoprotein capture proteomics to first define surface markers most-enriched on myeloma when compared to B-cell ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-27 | PXD022482 | Pride
Cell surface Plasma cell Multiple myeloma Immunotherapy 
ProteomicsMicro cell surface proteomics myeloma
The myeloma cell surface proteome (“surfaceome”) not only determines tumor interaction with the microenvironment but serves as an emerging arena for therapeutic development. Here, we use glycoprotein capture proteomics to first define surface markers most-enriched on myeloma when compared to B-cell ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-27 | PXD022553 | Pride
Cell surface Plasma cell Multiple myeloma 
ProteomicsGeneration of Nomo-1 cell surfaceome database
The goal was to build a custom proteome database for cell surface proteins of Nomo-1 (AML cell line). Such custom database was meant to facilitate cross-linking (XL-MS) of cell surface proteins for this cell line using non-cleavable cross-linkers. Using such custom database helps with the computatio...
ORGANISM(S): Homo sapiens (Human) 
2023-10-04 | PXD035404 | Pride
Aml and cell surfaceome Nomo-1 
ProteomicsFunctional multi-omics reveals genetic and pharmacologic regulation of surface CD38 in multiple myeloma
CD38 is a surface ectoenzyme expressed at high levels on myeloma plasma cells and is the target for the monoclonal antibodies (mAbs) daratumumab and isatuximab. CD38 density on tumor cells is an important determinant of mAb efficacy while CD38 is lost after mAb treatment. Several small molecules hav...
ORGANISM(S): Homo sapiens (Human) 
2021-07-29 | PXD027594 | Pride
Crispr-interference Atra Myeloma surfaceome Azacytidine Cd38 Panobinostat Daratumamab Phosphoproteomics 
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