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ProteomicsThe MYCN oncoprotein is an RNA-binding protein that promotes nascent RNA turnover via the NEXT targeting complex of the nuclear exosome
The MYCN oncoprotein forms a DNA-binding heterodimer with its partner protein MAX. MYCN-driven tumor cells depend on the nuclear exosome, a 3`-5` RNA exonuclease complex, to progress through S phase. Here we show that MYCN forms stable high molecular weight complexes with the nuclear exosome and add...
ORGANISM(S): Homo sapiens (Human) 
2024-07-18 | PXD044446 | Pride
Neuroblastoma Exosome Mycn Next Mxd Zcchc8 Myc Intron Max Mnt Eclip 
ProteomicsMYC multimers shield stalled replication forks from RNA polymerase
Oncoproteins of the MYC family drive the development of numerous human tumors. In unperturbed cells, MYC proteins bind to virtually all active promoters and control transcription by RNA Polymerase II (RNAPII). MYC proteins can also coordinate transcription with DNA replication and promote the repair...
ORGANISM(S): Homo sapiens (Human) 
2022-10-27 | PXD036674 | Pride
Brca1 Dsbs Rnapii Myc Replication fork Fancd2 Multimerization Antisense transcription Huwe1 
TranscriptomicsImplication of Nos2 inactivation on the transcriptome of developing cerebellum and Ptch1+/- medulloblastomas (mRNA)
The Ptch1+/- strain constitues an established mouse model for the Shh-driven type of medulloblastoma. Combined Ptch1+/- Nos2-/- mice show a two-fold increased incidence for this tumor. Here, the impact of Nos2 inactivation on medulloblastoma development was investigated by gene expression profiling...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-29192 | biostudies-arrayexpress
TranscriptomicsImplication of Nos2 inactivation on genomic changes in Ptch1+/- medulloblastomas (array-CGH)
The Ptch1+/- strain constitues an established mouse model for the Shh-driven type of medulloblastoma. Combined Ptch1+/- Nos2-/- mice show a two-fold increased incidence for this tumor. Here, the impact of Nos2 inactivation on copy number alterations during medulloblastoma development was investigat...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-29199 | biostudies-arrayexpress
TranscriptomicsTraffic-related Particulate Matter Upregulates Allergic Responses by a Notch-pathway Dependent Mechanism
The mechanisms by which diesel exhaust particles act as an adjuvant are unknown. We hypothesized that these would be mediated through monocyte interactions with DEP. We sought to identify pathways with a role in inflammation or other signaling mechanisms that might demonstrate the mechanism of respo...
ORGANISM(S): Homo sapiens 
2012-03-01 | E-GEOD-34025 | biostudies-arrayexpress
TranscriptomicsTranscribed ultraconserved region 339 promotes carcinogenesis by sequestering tumor suppressor microRNAs
The transcribed ultraconserved regions (T-UCRs) are a family of long non-coding RNAs implicated in human carcinogenesis. The mechanism of action of T-UCRs and the factors regulating their expression in human cancers are poorly understood. In this study we show that high expression of uc.339 correlat...
ORGANISM(S): Homo sapiens 
2015-07-07 | E-GEOD-70540 | biostudies-arrayexpress
UnknownElective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans.
Not available
S-EPMC7272903 | biostudies-literature
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