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ProteomicsMS-based analysis of the interacting proteins of human topoisomerases (TOP3A, TOP3B)
In this study, we used MS-based proteomics to identify the binding proteins of five human topoisomerases under four different conditions with treatment of CPT, ETO, HU, and NT. The proteomics result provide a quantitavie landscape of the binding partners of nearly all human topoisomerases. Several o...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD056278 | Pride
Mass spectrometry Protein interaction Human Proteomics Topoisomerases 
ProteomicsMS-based analysis of the interacting proteins of human topoisomerases (TOP1, TOP2A, TOP2B)
In this study, we used MS-based proteomics to identify the binding proteins of five human topoisomerases under four different conditions with treatment of CPT, ETO, HU, and NT. The proteomics result provide a quantitavie landscape of the binding partners of nearly all human topoisomerases. Several o...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD056277 | Pride
Mass spectrometry Protein interaction Human Proteomics Topoisomerases 
ProteomicsSupercharging-Enhanced nDIA-MS Enables Global Profiling of Drug-Induced Proteome Solubility Shifts (co-solvent)
Mass spectrometry (MS)-based proteomics has become indispensable for high-throughput quantitation of protein expression. However, protein function is regulated by a vari-ety of factors beyond abundance alone. Here, we optimized narrow-window, data-independent acquisition (nDIA) MS with 3% DMSO as a ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-11 | PXD064180 | Pride
Mnba Dmso Supercharging Ndia-ms 
ProteomicsSupercharging-Enhanced nDIA-MS Enables Global Profiling of Drug-Induced Proteome Solubility Shifts (solubility proteomics)
Mass spectrometry (MS)-based proteomics has become indispensable for high-throughput quantitation of protein expression. However, protein function is regulated by a variety of factors beyond abundance alone. Here, we optimized narrow-window, data-independent ac-quisition (nDIA) MS with 3% DMSO as a ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD064185 | Pride
Ml-792 Proteome Solubility shift Mg132 
ProteomicsLoss of KDM6A-mediated genomic instability and metabolic reprogramming regulates response to therapeutic perturbations in bladder cancer
Mutations in genes encoding critical epigenetic regulators are frequently noted in bladder cancer, however, the mechanisms by which these alterations impact the therapeutic response remain incompletely understood. Through retrospective analyses of multiple bladder cancer patient cohorts, we identifi...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-04 | PXD065234 | Pride
Kdm6a Genomic instability Metabolic reprogramming Bladder cancer 
ProteomicsOptimization of ultra fast nDIA proteomics approach
Rapid and comprehensive analysis of complex proteomes across large sample sets is essential to fulfill the potential of systems biology. We present a novel mass spectrometry (MS) method that integrates narrow-window data-independent acquisition (nDIA) with short-gradient micro-flow chromatography, e...
ORGANISM(S): Homo sapiens (Human) 
2026-01-14 | PXD055919 | Pride
Short gradient Proteomics Hela Ultra-fast Ndia 
ProteomicsMulti-organ quantitative proteome map following ASNase treatment
We applied the ultra-fast proteome profiling workflow to tissues collected from NSG mice treated with PBS (vehicle control), 20,000 U/kg ASNaseWT (Spectrila®), or 20,000 U/kg ASNaseQ59L for 0, 1, 3, 5, and 8 d. At each time point, mice were euthanized, and 13 tissues were collected, including subcut...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-14 | PXD055590 | Pride
Asparaginase Drug Proteomics Mass spectrometry Multi-organ 
UnknownResearch Trends and Dynamics in Single-cell RNA Sequencing for Musculoskeletal Diseases: A Scientometric and Visualization Study.
Not available
S-EPMC11783068 | biostudies-literature
UnknownSuperhydrophobic lotus-leaf-like surface made from reduced graphene oxide through soft-lithographic duplication.
Not available
S-EPMC9049290 | biostudies-literature
UnknownA mouse brain atlas based on dendritic microenvironments.
Not available
S-EPMC12779555 | biostudies-literature
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