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ProteomicsFast and Accurate Disulfide Bridge Detection
Recombinant expression of proteins, propelled by therapeutic antibodies, has evolved into a multi-billion-dollar industry. Essential here is quality control assessment of critical attributes such as sequence fidelity, proper folding, and post-translational modifications (PTMs). Errors can lead to di...
ORGANISM(S): Homo sapiens (Human) 
2024-04-08 | PXD046855 | Pride
Faims Disulfide Ethcd Mab Scrambling 
ProteomicsMonolinks Matter: Rational Modification of a Cross-Linker for Improved Flexible Protein Structure Modeling
Chemical cross-linking/mass spectrometry (XL-MS) has emerged as a complementary tool for mapping interaction sites within protein networks as well as gaining moderate-resolution native structurale insight with minimal interference. XL-MS technology mostly relies on chemoselective reactions (crosslin...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051742 | Pride
Protein structure Alphafold Crosslink Dsso-carbamate Monolink 
ProteomicsEfficient and robust proteome-wide approaches for crosslinking mass spectrometry
Proteome-wide crosslinking of PC9 cell lysates with DSSO
ORGANISM(S): Homo sapiens (Human) 
2018-06-15 | PXD008418 | Pride
Xlinkx Xl-ms Dsso 
ProteomicsInteraction of saposin C and acid-beta-glucosidase
The objective of this project was to determine the interaction interface(s) between acid beta-glucosidase (GCase) and its activator protein saposin C (SapC). Chemical crosslinking was used to confirm the formation of discrete heterodimers between the two proteins, using lysine-reactive crosslinkers ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058056 | Pride
Gaucher Lysosome Glucosidase Saposin Crosslinking 
ProteomicsInteractions between basic helix-loop-helix transcription factors and nucleosomes
In solution crosslinking mass spectrometry of transcription factors in complex with nucleosomes
ORGANISM(S): Homo sapiens (Human) 
2023-05-23 | PXD033181 | Pride
Dsso crosslinking xlinkx pd transcription factor nucleosome human 
ProteomicsThe catalytic activity of TCPTP is auto-regulated by its intrinsically disordered tail and activated by Integrin alpha-1
T-Cell Protein Tyrosine Phosphatase (TCPTP, PTPN2) is a non-receptor type protein tyrosine phosphatase that is ubiquitously expressed in human cells. TCPTP is a critical component of a variety of key signaling pathways that are directly associated with the formation of cancer and inflammation. Thus,...
ORGANISM(S): Homo sapiens (Human) 
2021-11-10 | PXD029256 | Pride
Tcptp Ptpn2 Intermolecular cx-ms Intramolecular cx-ms 
ProteomicsSelennoprotein S interacts with the replication and transcription complex of the SARS-CoV-2 by binding nsp7
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) replicates and evades detection by using endoplasmic reticulum (ER) membranes and their associated protein machineries. Among these hijacked human ER proteins is selenoprotein S, which usually takes part in the ER protein degradation p...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD038629 | Pride
Selenos Nsp12 Nsp8 Covid-19 Vimp 
ProteomicsHAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1
Huntington’s disease results from expansion of a glutamine-coding CAG tract in the huntingtin (HTT) gene, producing an aberrantly functioning form of HTT. Both wildtype and disease-state HTT form a hetero-dimer with HAP40 of unknown functional relevance. We demonstrate in vivo and in cell models tha...
ORGANISM(S): Homo sapiens (Human) 
2022-09-09 | PXD028415 | Pride
Saxs Huntingtin Xl-ms Cryo-em Integrative modeling 
ProteomicsHAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1
Huntington’s disease results from expansion of a glutamine-coding CAG tract in the huntingtin (HTT) gene, producing an aberrantly functioning form of HTT. Both wildtype and disease-state HTT form a hetero-dimer with HAP40 of unknown functional relevance. We demonstrate in vivo and in cell models tha...
ORGANISM(S): Homo sapiens (Human) 
2022-02-21 | PXD028313 | Pride
Saxs Huntingtin Xl-ms Cryo-em Integrative modeling 
ProteomicsMC4 crosslinking of rhodopsin and GRK1 complex
G protein-coupled receptor (GPCR) kinases (GRKs) selectively phosphorylate agonist bound GPCRs, thereby switching the signal from G protein-dependent to arrestin-dependent pathways, including receptor internalization and downregulation. There are currently no high-resolution details known about how ...
ORGANISM(S): Bos taurus (Bovine) 
2021-07-15 | PXD019215 | Pride
Mc4 Grk1 Rhodopsin Crosslinking Gpcr Rhodopsin kinase 
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