Sort   by:  
 Page size 
ProteomicsMorquio A syndrome: identification of differential patterns of molecular pathway interactions in bone lesions
Mucopolysaccharidosis type IVA (MPS IVA; Morquio A syndrome) is a rare autosomal recessive lysosomal storage disease (LSD) caused by deficiency of a hydrolase enzyme, N-acetylgalactosamine-6-sulfate sulfatase, and characterized clinically by mainly musculoskeletal manifestations. The mechanisms unde...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD042166 | Pride
Morquio a syndrome Rare disease Swath-ms Protein biomarker 
ProteomicsNovel phenotypical and biochemical findings in mucolipidosis type II
Mucolipidosis type II (ML II) is a rare lysosomal storage disorder caused by deficiency of the UDP-GlcNAc:N-acetylglucosamine-1-phosphotransferase enzyme, which catalyzes the synthesis of the mannose-6-phosphate (M6P) targeting signal for lysosomal acid hydrolases. This deficiency hinders lysosomal ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD060270 | Pride
Mucolipidosis ii-iii  early findings  biochemistry  biomarkers  proteomic studies  lysosomal diseases. 
ProteomicsQuantitative Proteomic Study Unmasks Fibrinogen Pathway in Polycystic Liver Disease
(1) Background: Polycystic liver disease (PLD) is a heterogeneous group of congenital disorders characterized by bile duct dilatation and cyst development derived from cholangiocytes. Nevertheless, the cystogenesis mechanism is currently unknown and the PLD treatment is limited to liver transplantat...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD031253 | Pride
Pld  swath  quantitative proteomics  therapeutic targets 
ProteomicsCirculating extracellular vesicles as biomarkers to monitor response to Multiple Sclerosis therapy.
In the last two decades, several disease-modifying treatments (DMTs) have been developed for MS. These therapies are based on the modulation of the immune system and the aim to reduce the disease activity. However, as the natural course of the disease is unpredictable, the benefit of each treatment ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD048002 | Pride
Micrornas Proteomics Treatment response Extracellular vesicles Biomarkers Multiple sclerosis 
ProteomicsIdentification and phosphorylation site mapping of a sperm specific PKA C subunit isoform from Mytilus galloprovincialis
This project investigates a sperm-specific isoform of the catalytic (C) subunit of cAMP-dependent protein kinase (PKA) in the marine mussel Mytilus galloprovincialis, an externally fertilizing invertebrate widely used as a model for gamete activation studies. A C-subunit isoform purified from male g...
ORGANISM(S): Crenomytilus 
2026-09-07 | PXD076788 | Pride
Camp-dependent protein kinase  pka  catalytic subunit  lc–ms/ms  phosphoproteomics  phosphorylation sites  tio₂ enrichment  mytilus galloprovincialis  sperm 
ProteomicsColchicine Suppresses Adipogenic Differentiation of Mesen-chymal Stem Cells: Implications for Bone Adiposity Control
Background: Gout is an inflammatory arthritis associated with increased bone anabolism and a higher risk of ectopic bone formation. Colchicine, used to prevent and treat acute gouty flares, inhibits microtubule polymerization and has been described to promote osteoblastogenesis. In bone disorders su...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-02 | PXD072951 | Pride
Adipogenesis  osteoblastogenesis  cytoskeleton  microtubule destabilization  bone marrow adipocytes 
ProteomicsLinking First-Pass Reperfusion Success to Proteomic Markers in Large and Medium Vessel Ischemic Stroke
Mechanical thrombectomy (MT) has improved disability outcomes after ischemic stroke (IS), mainly when the so-called modified first-pass effect (mFPE) is achieved. This study aims to explore the proteomic profiling of thrombi composition in those patients who achieved mFPE. A prospective study was co...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD066161 | Pride
Biological pathways  ischemic stroke  mechanical thrombectomy  proteomics  thromboinflammation 
ProteomicsRelaxin-2: shaping the proteomic landscape of skeletal muscle physiology, glucose trafficking, and mitochondrial function in rat.
Relaxin-2 is a hormone with robust beneficial effects on the heart and blood vessels and with a potential therapeutic efficacy in cardiovascular (CV) disease. Considering the interorgan communication between skeletal muscle and heart, and the relation between muscle quality/composition and CV events...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-09-21 | PXD078619 | Pride
Serelaxin Phosphoproteome Mitochondrial respiration Metabolism. Skeletal muscle Relaxin-2 Myogenesis Proteome 
ProteomicsThe proteome of circulating extracellular vesicles and their functional effect on platelets vary with the isolation method
Extracellular vesicles (EVs) play a crucial role in cell-to-cell communication and serve as a source of biomarkers in several pathologies. In this study, we aimed to characterize plasma-derived EVs isolated by ultracentrifugation (UC) or size exclusion chromatography (SEC) to define the best method ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-14 | PXD056613 | Pride
Platelets Ultracentrifugation Extracellular vesicles Size exclusion chromatography Proteomics. 
ProteomicsNeddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism
Neddylation is a post-translational mechanism that adds a ubiquitin-like protein, namely neural precursor cell expressed developmentally down-regulated protein 8, to target proteins, with yet-unknown consequences. Here we show in mice that neddylation in liver is modulated by nutrient availability. ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-08 | PXD043054 | Pride
Pck1 Neddylation Glucose 
Sort   by:  
 Page size