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MetabolomicsTranscriptome and metabolome changes in Chinese cedar during cold acclimation reveal the roles of flavonoids in needle discoloration and cold resistance

Cryptomeria fortunei growth and development are usually affected by low temperatures. Despite the evergreen nature of this species, most needles turn yellowish-brown in cold winters. The underlying discoloration mechanisms that cause this phenomenon in response to cold acclimation remain...

2022-08-12 | MTBLS3184 | MetaboLights
ProteomicsPhosphoproteomics analysis of CHK1 inhibitor treatment
Inhibitors of checkpoint kinase 1 (CHK1),a central component of DNA damage and cell cycle checkpoint response, represent a promising new cancer therapy, but the global cellular functionsthey regulate through phosphorylationare poorly understood. To elucidate the CHK1-regulated phosphorylation networ...
ORGANISM(S): Homo sapiens (Human) 
2020-04-23 | PXD015125 | Pride
Chk1 inhibitor Silac Phosphoprotomics 
ProteomicsHuman DNA Mismatch Repair pathway LC-MSMS
The mismatch repair (MMR) family is a highly conserved group of proteins that function in correcting base-base and insertion-deletion mismatches generated during DNA replication. To systematically investigate the mismatch repair pathway, we conducted a proteomic analysis and identified MMR-associate...
ORGANISM(S): Homo sapiens (Human) 
2016-02-08 | PXD003014 | Pride
Human Hek-293t Tap Mmr 
ProteomicsComprehensive analysis of the host-virus interactome of SARS-CoV-2
Host-virus protein-protein interaction is the key component of SARS-CoV-2 life cycle, which can be targeted for therapeutic intervention. Thus, we conducted a comprehensive interactome study between the virus and host cell using tandem affinity purification (TAP) and BioID2 labeling strategies. In a...
ORGANISM(S): Homo sapiens (Human) 
2021-06-29 | PXD023209 | Pride
Sfb-tap Sars-cov-2 Human coronavirus Host-virus protein-protein interaction Bioid2 Interactome 
ProteomicsInteractome of AMPK complex study using TAP-MS
The adenosine monophosphate-activated protein kinase (AMPK) complex is a key enzyme in regulating cellular energy homeostasis. This complex is well studied and it is known to function in many cellular pathways. However, the interactome of AMPK complex has not yet been systematically established, alt...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD015466 | Pride
Interactome Ampk Tap 
ProteomicsASF1 acts with RIF1 to promote DNA end-joining in BRCA1 deficient cells
RIF1 acts downstream of 53BP1 to coordinate DNA double strand break repair pathway choice between non-homologous end joining (NHEJ) and homologous recombination (HR). Here we identified ASF1 as an endogenous RIF1-associated protein. We showed that ASF1 forms complex with RIF1 and regulates RIF1-depe...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD027727 | Pride
Rif1 Tap-ms Asf1 Interactome 
ProteomicsGlobal Phosphoproteomic Analysis Reveals ARMC10 as an AMPK Substrate that Regulates Mitochondrial Dynamics
AMP-activated protein kinase (AMPK) is a key regulator of cellular energy homeostasis. Although AMPK has been studied extensively in cellular processes, understanding of its substrates and downstream functional network, and their contributions to cell fate and disease development, remains incomplete...
ORGANISM(S): Homo sapiens (Human) 
2019-01-16 | PXD011696 | Pride
Phosphoproteomics Ampk Silac Lc-ms/ms 
ProteomicsPCNA interactome - SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair
We examined the complexity of replication fork composition upon DNA damage by employing a PCNA-based proteomic screen to uncover known and new players involved in replication and replication stress response. We used camptothecin or ultraviolet radiation, that lead to fork-blocking lesions, to establ...
ORGANISM(S): Homo sapiens (Human) 
2018-12-14 | PXD011727 | Pride
Pcna Bioid Interactome 
ProteomicsSLX4 and SLX4IP TAP-MS - SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair
Interstrand crosslinks (ICLs) are highly toxic DNA lesions, which are repaired via a complex process that requires the coordination of several DNA repair pathways. Defects in ICL repair result in Fanconi anemia (FA), which is diagnosed with bone marrow failure, development abnormalities and high inc...
ORGANISM(S): Homo sapiens (Human) 
2019-09-13 | PXD012521 | Pride
Sfb Slx4 Tap-ms Slx4ip 
ProteomicsMutant p53 interactome study with IP-MS
Inactivating TP53 mutations lead to a loss of function of p53, but can also often result in oncogenic gain-of-function (GOF) of mutant p53 (mutp53) proteins which promote tumor development and progression. The GOF activities of TP53 mutations are well documented, but the mechanisms involved remain p...
ORGANISM(S): Homo sapiens (Human) 
2023-11-27 | PXD047094 | Pride
Ms Ip Mutant p53 P53 
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