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ProteomicsNeurodevelopmental Impact of Prenatal Stress: A Proteomic Analysis of Myelination Disruptions in the Avian Embryo
Prenatal stress induced by maternal activation of the hypothalamic-pituitary-adrenal (HPA) axis and subsequent release of glucocorticoids can profoundly affect fetal brain development. This study investigates the molecular mechanisms underlying prenatal stress in Gallus gallus domesticus by analyzin...
ORGANISM(S): Gallus gallus (Chicken) 
2025-10-27 | PXD055206 | Pride
Gallus gallus domesticus Proteomics Myelin Prenatal stress Corticosterone 
ProteomicsSystematic evaluation of morphological and molecular changes in SH-SY5Y cells induced by common differentiation protocols with a particular focus on the abundance of neuronal subtypes
The SH-SY5Y cell line is a triple-cloned subline of SK-N-SH cells that were originally isolated in the early 1970s from a bone marrow biopsy of a four-year-old female patient suffering from neuroblastoma. Since then, this cell line has been used as one of the major cell culture models in neuroscienc...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD064335 | Pride
Sh-sy5y Proteomics Mass spectrometry Differentiation Neuronal subtype 
ProteomicsProteomics of Duchenne Muscular Dystrophy Patient iPSC - Derived Skeletal Muscle Cells Reveal Differential Expression of Myosin 9, Collagen 18A, Tropomyosin 1, NCAM1, BASP1 and RUVBL1
Proteomics of skeletal muscular dystrophies is limited by the amount of protein which can be provided from patient biopsies. Cells and tissues derived from patient induced pluripotent stem cells (iPSCs) can be an expandable alternative source. We have patterned iPSCs from three Du-chenne Muscular Dy...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD068000 | Pride
Organoids Patient induced pluripotent stem cells Disease modelling Duchenne muscular dystrophy Proteomics Skeletal muscle 
ProteomicsProteomic characterization of synaptosomes from human substantia nigra indicates altered mitochondrial translation in Parkinson’s disease
Parkinson´s disease (PD) feature a progressive degeneration of dopaminergic neurons in the substantia nigra (SN). Additionally, numerous studies indicate an altered synaptic function during the course of PD. In order to characterize the proteome of synaptosomes isolated from the substantia nigra and...
ORGANISM(S): Homo sapiens (Human) 
2021-06-07 | PXD022092 | Pride
Parkinson's disease Mass spectrometry Subcellular fractionation 
ProteomicsThe protective effect of docosahexaenoic acid on mitochondria in a SH-SY5Y model of rotenone-induced toxicity
Polyunsaturated fatty acids in particular omega-3 fatty acids, such as docosahexaenoic acid (DHA) are essential nutrients and components of the plasma membrane. They are involved in various processes, among them synaptic development, functionality, integrity and plasticity and are therefore thought ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-24 | PXD049302 | Pride
Dha Proteomics Rotenone Mitochondria Sh-sy5y 
ProteomicsLoss of Atoh8 impairs macroautophagy
The basic helix-loop-helix (bHLH) transcription factor ‘Atoh8’ is involved in the regulaton of several developmental processes and pathologies. It regulates organogenesis, reprogramming, stem cell fate determination, and cancer development. However, the mech anisms underlying these observations rema...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-05 | PXD070896 | Pride
Metabolism Tfeb Atoh8 Ros Macroautophagy P62 Autophagy 
ProteomicsAdvanced fiber type-specific protein profiles derived from adult murine skeletal muscle
Skeletal muscle is a heterogeneous tissue consisting of blood vessels, connective tissue, and muscle fibers. The last are highly adaptive and can change their molecular composition depending on external and internal factors, such as exercise, age, and disease. Thus, examination of the skeletal muscl...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-07 | PXD025359 | Pride
Laser microdissection Proteomics Neuromuscular disorders Skeletal muscle Fiber types 
ProteomicsFiber type-specific proteomic alterations in R349P desminopathy mice
Desminopathies refer to a group of rare human myopathies and cardiomyopathies, caused by mutations in the desmin gene. So far, there is no causative treatment and little is known about early pathological effects, since alterations in muscle biopsies usually reflect late stages of the disease. Thus, ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-26 | PXD049207 | Pride
Myofibrillar myopathy Desmin Proteomics Fiber types 
ProteomicsThe aging Substantia nigra is characterized by ROS accumulation potentially resulting in a perturbed mitochondrial homeostasis, increased neuroinflammation and cytoskeletal remodelling
Ageing is a progressive and irreversible process that ultimately leads to death, serving as the primary risk factor for neurodegenerative disorders. This study aims to identify the molecular mechanisms underlying physiological ageing within the substantia nigra, which is primarily affected in Parkin...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051145 | Pride
Laser microdissection Substantia nigra Proteomics Dia Aging 
ProteomicsDesmin knock-out cardiomyopathy: a heart on the verge of metabolic crisis
Background: Mutations of the desmin gene cause familial and sporadic cardiomyopathies and myopathies. Previous studies showed that both the lack of desmin and expression of mutated desmin negatively impact on number, structure and function mitochondria implying a metabolic dysfunction as disease pro...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-21 | PXD030938 | Pride
Metabolism Fatty acid Desmin Mitochondria Glucose Desminopathy Desmin knock-out Creatine kinase Cardiomyopathy Amino acid 
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