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ProteomicsDetermine PARP1 and PARP2 target engagment of Niraparib and Olaparib in live cells
Determine the target engagment of PARP inhibitors (Niraparib and Olaparib) to PARP1 and PAPR2 in live cells using isothermal dose-response experiments
ORGANISM(S): Homo sapiens (Human) 
2025-05-13 | PXD044332 | Pride
Parp2 Parp1 Tpp Niraparib Itdr Olaparib 
ProteomicsOff-target profiling of Niraparib and Olaparib using Thermal Proteome Profiling
Explore off-targets of Niraparib and Olaparib using 2D Thermal Proteome Profiling (2D-TPP)
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044334 | Pride
Thermal proteome profiling Parp Niraparib 2d-tpp Olaparib 
ProteomicsOff-target profiling of Olaparib using Thermal Proteome Profiling
Explore off-targets of Olaparib using 2D Thermal Proteome Profiling (2D-TPP)
ORGANISM(S): Homo sapiens (Human) 
2024-05-13 | PXD046614 | Pride
Thermal proteome profiling Parp 2d-tpp Olaparib 
ProteomicsMultiplexed proteome dynamics profiling of HSP90 inhibitor 17-AAG in anti-CD3 and anti-CD28 stimulated T-cells
Investigation of proteostatic effects of HSP90 inhibition by 17-AAG and differentiation of maturation state dependent HSP90 requirements of proteins in activated T-cells.
ORGANISM(S): Homo sapiens (Human) 
2018-05-02 | PXD008634 | Pride
Hsp90 Anti-cd28 Activated t-cells 17-aag Mpdp Primary t-cells Anti-cd3 
ProteomicsMultiplexed proteome dynamics profiling of Estradiol and SERMs
Investigation of proteostatic effects of Estradiol, raloxifen and GW7604 in MCF7 cells.
ORGANISM(S): Homo sapiens (Human) 
2018-05-02 | PXD008636 | Pride
Gw7604 Mpdp Raloxifen Estradiol 
ProteomicsMultiplexed proteome dynamics profiling of HSP90 inhibitor 17-AAG in T-cells
Investigation of proteostatic effects of HSP90 inhibition by 17-AAG and differentiation of maturation state dependent HSP90 requirements of proteins in resting T-cells.
ORGANISM(S): Homo sapiens (Human) 
2018-05-02 | PXD008635 | Pride
Hsp90 17-aag Mpdp Primary t-cells 
ProteomicsMultiplexed proteome dynamics profiling of HSP90 inhibitor 17-AAG
Investigation of proteostatic effects of HSP90 inhibition by 17-AAG and differentiation of maturation state dependent HSP90 requirements of proteins.
ORGANISM(S): Homo sapiens (Human) 
2018-04-05 | PXD008633 | Pride
Hsp90 17-aag Mpdp 
ProteomicsMultiplexed proteome dynamics profiling of JQ1-PROTAC
Goal of this experiment was the differentiation of direct targets of induced degradation of the JQ1-PROTAC from downstream regulatory effects.
ORGANISM(S): Homo sapiens (Human) 
2018-05-02 | PXD008637 | Pride
Vhl Protac Mpdp Jq1 
ProteomicsThermal proteome profiling of JQ1
Goal of this experiment was the identification of proteins affected in their thermal stability by JQ1.
ORGANISM(S): Homo sapiens (Human) 
2018-05-02 | PXD008638 | Pride
Jq1 Tpp 
ProteomicsT-cell protein half live - Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis
Determine half lives of proteins in T-cells using dynamic SILAC labeling
ORGANISM(S): Homo sapiens (Human) 
2018-05-02 | PXD008630 | Pride
Dynamics silac Turnover Half live 
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